This is an automatically translated article.
Oxaliplatin Medac is used in the treatment of rectal cancer and should be used exactly as prescribed by your doctor. So what is the use of Oxaliplatin Medac and what dosage should users take?1. Indications Oxaliplatin Medac
Oxaliplatin Medac should be used as prescribed by a specialist in the treatment of some of the following conditions:
Stage III colon cancer (Duke's C) after complete resection of the primary tumor. Treatment of metastatic colorectal cancer.
2. Contraindications of Oxaliplatin Medac
Oxaliplatin Medac is contraindicated in some cases as follows:
People with a history of allergy to Oxaliplatin and components contained in Oxaliplatin Medac. Women are breastfeeding. Patients with myelosuppression before the first course of treatment (based on neutrophil counts less than 2 x 10 to 9/L or platelets < 100 x 10 to 9/L). Patients with peripheral sensory neuropathy. People with severely impaired renal function (creatinine <30 mL/min).
3. Instructions for using Oxaliplatin Medac
Patients only use Oxaliplatin Medac according to the instructions and regimen of the treating doctor. Reference dosage according to the manufacturer's instructions is as follows:
3.1 Dosage: Supportive treatment dose: 85 mg/m2 IV infusion for 2 weeks in 12 courses.
Dosage of Oxaliplatin Medac will be adjusted based on blood test results and patient response status.
3.2 How to use: In the case of Oxaliplatin combined with folinic acid (calcium folinate or disodium folinate):
Oxaliplatin 85mg/m2 intravenously with 250 to 500ml of 5% glucose infusion. Note: Do not put two pills in the same bag. In the case of Oxaliplatin in combination with 5-fluorouracil:
Oxaliplatin is always given before fluoropyrimidines (eg 5-fluorouracil). After administering Oxaliplatin, healthcare workers should wash the line and continue infusion of 5-flourouracil. In case the solution after reconstitution has a precipitate, it should be discarded immediately.
Instructions on how to mix topically:
Use distilled water for injection or glucose 5% solution to make the drug. Use an additional I0ml of solvent to achieve an oxaliplatin concentration of 5mg/mL. Only clear solutions should be used without foreign matter, without precipitation.
Dilute the solution before infusion:
Take an adequate amount of the above diluent, then dilute it with 250-500ml of 5% glucose solution to get oxaliplatin solution at a concentration of 0.2-0.7 mg/mL and give it into the patient's body through intravenous infusion
Note: The solution is stable for 24 hours with a temperature of 2 to 8°C.
Infusion instructions:
No need to rehydrate before Oxaliplatin infusion. Oxaliplatin reconstituted in 250-500 mL of 5% glucose solution to a concentration of not less than 0.2 mg/ml should be infused intravenously (peripheral, central vein) over 2 to 6 hours. In case of use in combination with 5-fluorouracil, Oxaliplatin must be infused before 5-fluorouracil solution.
4. Interactions, incompatibilities Oxaliplatin
Oxaliplatin Medac should not be mixed with other drugs in the same infusion bag or used in the same infusion line.
Taking a single dose of Oxaliplatin Medac before 5-flourouracil did not change 5-flourouracil concentrations.
5. Overdose and treatment of Oxaliplatin
Currently there is no antidote for Oxaliplatin overdose. Therefore, in case of overdose, the symptoms of side effects will become worse. The patient should be taken to the nearest medical facility immediately for timely support.
6. Some side effects when using Oxaliplatin
During the use of Oxaliplatin, patients may experience some side effects as follows:
Appears persistent vomiting or diarrhea; Stomatitis or inflammation of the oral mucosa, mouth ulcers; Edema in some places: face, lips, mouth or throat. Dry cough, difficulty breathing, crackles sound in the lungs. Difficulty swallowing; Numbness or sharp pain in the extremities; Exhausted; Bruising or bleeding; There are signs of infection such as sore throat and high fever. Discomfort at the injection site during infusion The above mentioned side effects may be incomplete, because each patient's body is different. Depending on the location of the patient, there will be side effects that may appear individually or simultaneously. Inform your doctor about side effects.
7. Some cautions when using Oxaliplatin Medac
Patients when using Oxaliplatin Medac should follow the doctor's instructions. In addition, patients should note some warnings as follows:
Oxaliplatin Medac should be prescribed and guided for use by a specialist in cancer treatment. People with kidney failure should consult a doctor before taking the drug. People with a history of allergy to platinum active ingredients (including platinum atomized with 1,2-diaminocyclohexane ("DACH") and the oxalate group) should use caution when using Oxaliplatin Medac. Discontinue Oxaliplatin Medac infusion in patients with extravasation and initiate local symptomatic treatment. Patients with acute oropharyngeal dysarthria: After Oxaliplatin infusion, the next dose should be 6 hours apart from the previous dose. An antiemetic or prophylactic treatment should be used if the patient develops vomiting and nausea while taking Oxaliplatin. Blood tests should be performed prior to each course of Oxaliplatin treatment. Women should not become pregnant during treatment with Oxaliplatin and should use appropriate contraception. Pregnant and nursing women should consult their doctor before using Oxaliplatin. Driving and operating machinery should be used with caution, as the drug may increase the risk of dizziness, nausea and vomiting. The use of Oxaliplatin Medac will be ensured when the drug is stored at a temperature below 30 degrees Celsius. The solution after mixing should be stored at a temperature of 2 - 8 degrees C within 24 hours. Information on the use of Oxaliplatin Medac is for reference only. Patients should use the drug according to the instructions and instructions of the specialist doctor as well as the professional pharmacist for the best and safest.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
