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Schizophrenia, manic episodes or prevention of relapse of bipolar disorder are common indications for olanzapine. This active ingredient is in Olmac 5. So in addition to the above indications, what are the uses of Olmac 5?
1. What is Olmac 5?
Olmac 5 is a psychotropic drug, commonly used in the treatment of schizophrenia and a number of other psychiatric conditions. Olmac 5's main ingredient is Olanzapine, so Olmac 5's use is to reduce psychotic symptoms, paranoia, help control consciousness, behavior and language, improve the ability to express happy and surprised emotions. However, hope, and at the same time help the patient not to be indifferent and emotionless as before. Olmac 5 is available as a film-coated tablet and is only suitable for use by adults and children 13 years of age and older.2. Indications and uses of Olmac 5
Olmac 5 products are indicated in the following cases:
Patients with schizophrenia ; Treatment of moderate to severe mania; Prevention of relapse of bipolar disorder in patients whose manic episodes have responded to olanzapine; Olmac 5 is also used to maintain clinical improvement in patients who have responded to first-line therapy.
3. Instructions for using Olmac 5
Olmac 5 is prepared in tablet form for oral use with the following specific dosages:
Adults: Schizophrenia: It is recommended to initiate Olanzapine at a dose of 10mg/day (2 Olmac 5 tablets); Moderate to Severe Mania: It is recommended to initiate Olanzapine at 15 mg once (3 Olmac 5 tablets) daily as monotherapy, or 10 mg (2 Olmac 5 tablets) daily in combination therapy; Prevention of bipolar disorder: The recommended starting dose is 10mg/day, equivalent to 2 Olmac 5 tablets; Patients already treated for manic episodes with olanzapine should continue their relapse prophylaxis at the same dose. In the event of a new manic, mixed or depressive episode, the patient should continue treatment with Olmac 5 (adjust the optimal dose if necessary) in combination with symptomatic therapy as indicated. clinical; Olmac 5 dose for children 13-17 years of age: Caution should be exercised and under the supervision of a specialist: Schizophrenia: Start with a dose of 2.5-5 mg orally once a day, target dose is 10mg/day (2 Olmac 5 tablets) and the maximum dose is 20mg/day; Bipolar disorder: Initial: 2.5-5 mg/day orally once, target dose 10mg/day. The doctor may increase or decrease the dose every 2.5 or 5mg up to a maximum dose of 20mg/day (4 Olmac 5 tablets); Olmac 5 dosage for the elderly: Start with a low dose: 5mg/day). However, Olmac 5 should not be prescribed routinely but must be considered in patients over 65 years of age when clinical factors allow; Olmac 5 dosage for patients with renal and/or hepatic impairment: The starting dose is lower than usual (5mg/day). Patients with moderate hepatic impairment (cirrhosis, Child-Pugh A or B) should start with 5mg/day (1 Olmac 5 tablet/day) and be cautious when increasing the dose.
4. Contraindications to use Olmac 5
People with a history of allergy to Olanzapine or any of the ingredients of Olmac 5 ; People at risk of narrow-angle glaucoma; Women who are pregnant or breastfeeding should avoid taking Olmac 5 so as not to affect the health of the fetus and nursing infant.
5. Some special notes when using Olmac 5
People who need to be careful before taking Olmac 5, including the elderly, pregnant women, nursing mothers, children under 15 years old, people with liver failure, kidney failure, people who are sensitive to any of the ingredients. any of the products... or patients with myasthenia gravis, hepatic coma, stomach ulcers ... Limit or not use Olmac 5 for pregnant or lactating women. There are no specific reports on the effects of Olmac 5 products on drivers and operators. However, to ensure safety, patients should consult their doctor or pharmacist before use.
6. Olmac 5 . side effects
Some common side effects when taking Olmac 5 , including weight gain, drowsiness, increased blood prolactin levels...
Some less common Olmac 5 side effects include:
Increased eosinophils acid ; Increased levels of cholesterol, glucose, triglycerides in the blood; Increased appetite; Dizzy; Jitter; Movement disorders; Orthostatic hypotension; Rash; Attenuate; Tired. If patients experience any unusual signs while using Olmac 5, please contact your doctor for advice and timely resolution.
7. Olmac 5 . Drug Interactions
Several drug interactions may affect the efficacy of Olmac 5:
Olanzapine in Olmac 5 is metabolised by CYP1A2 nsnd active substances that can either induce or inhibit CYP1A2 may affect the pharmacokinetics of Olanzapine: CYP1A2 enzyme inducer: The metabolism of Olmac 5 can be stimulated by tobacco and carbamazepine, which may result in decreased olanzapine blood concentrations and a slight to moderate increase in olanzapine clearance; Inhibitors of CYP1A2: Fluvoxamine, a specific CYP1A2 inhibitor has been shown to significantly inhibit the metabolism of Olmac 5. Therefore, a lower starting dose of Olmac 5 should be considered in patients receiving fluvoxamine or any other CYP1A2 inhibitor such as ciprofloxacin. Also consider reducing the dose of Olmac 5 if the patient has been treated with a previous CYP1A2 inhibitor; Reduced bioavailability: Activated charcoal reduces the oral bioavailability of Olanzapine by 50-60%, so it should be taken at least 2 hours before or after Olmac 5; Fluoxetine (a CYP2D6 inhibitor), single dose of an antacid (aluminum, magnesium) or cimetidine did not significantly affect the pharmacokinetics of Olmac 5. Some effects of Olmac 5 on other drugs:
Olmac 5 may directly and indirectly antagonize the effects of Dopamine agonists; Olmac 5 does not inhibit the major CYP450 isoenzymes in vitro (eg, 1A2, 2D6, 2C9, 2C19, 3A4). Therefore, no special interactions are expected in the in vitro study groups due to the absence of metabolic inhibition by tricyclic antidepressants, Warfarin, Theophylline or Diazepam; Central Nervous System Activity: Olmac 5 should be used with caution in patients using alcohol or other CNS depressants; QT interval: Caution should be exercised when Olmac 5 is used concomitantly with other drugs that increase the QT interval. Olmac 5 is a psychotropic drug, commonly used in the treatment of schizophrenia and a number of other psychiatric conditions. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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