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Nystatin has many dosage forms, among which is the Nystatin package containing 25,000IU of oral powder with the effect of killing Candida fungi that can be used for both infants and adults. So to find out specifically what Nystatin drug works? Let's find out the necessary information about the use of nystatin tablets through the article below.
1. What is the effect of the Nystatin package?
Nystatin drug package belongs to the group of antifungal drugs, is made in the form of a powder packed with a content of 1 gram per pack, the drug is manufactured by OPC Pharmaceutical Joint Stock Company.
Each pack of medicine has: main ingredient is Nystatin 25,000IU, Excipients: Sorbitol, Vanilin
Nystatin medicine package is prescribed by doctors to be used in case of treatment and prevention of oral candidiasis. called thrush): stomatitis, thrush, tongue loss of papillae, pharyngitis caused by Candida albicans.
Nystatin has only local effects, is not absorbed into the blood, so it is not toxic and does not affect the health of children.
The main ingredient in oral thrush is Nystatin. This is an antifungal active ingredient extracted from the culture of Streptomyces noursei. The bacteria most sensitive to Nystatin are yeasts and have the best effect on Candida albicans.
Nystatin binds to fungal cell membrane sterols, altering membrane permeability and function, and potassium and other essential fungal cell components are depleted. Since then, Nystatin helps kill many types of yeast and has the best effect on Candida albicans. When resistant, Candida resistant to nystatin is also resistant to other antifungal polyenes. Symptoms of a Candida infection should subside within 24-72 hours.
In addition, in nystatin also contains the active ingredients: sodium carboxymethyl cellulose, methyl p-hydroxybenzoate (E218), propyl p-hydroxybenzoate (E216), sodium metabisulphite (E223), sucrose, sodium saccharin, sodium citrate, anise flavor determined, pure water.
Nystatin antifungal drugs generally have many dosage forms such as: oral tablets, topical drugs, suspensions, vaginal tablets, powder pills. Particularly for the drug Nystatin to treat oral thrush, it is usually used in powder form to mix suspension or lozenges.
Nystatin drug is effective against superinfection of Candida albicans gastrointestinal tract during antibiotic treatment. The drug is used topically, not for the treatment of systemic candidiasis.
2. Usage of Nystatin drug package for each subject
Put the required amount of medicine into a small glass containing 1 teaspoon of boiled and cooled water available, stir to disperse evenly, use sterile gauze to wrap your fingers, soak the medicine in the tongue, throat,... any where the fungus grows. For 20 minutes after opening the mouth do not eat or drink. Only mix medicine enough for 1 time use, can swallow the medicine.
Because it is not absorbed into the blood, causing little systemic effects, nystatin drugs are relatively safe to use in all subjects. However, the drug needs to have enough contact time in the oral cavity to maximize its effect. Therefore, for each object, there will be a different way to use each dosage form.
2.1. Infants and children under 5 years of age Drug form: Nystatin powder sachet for children's tongue
Dosage:
Infants: 1⁄2 packs 1g each time, 2 times a day Children under 5 years old: 1 pack 1g each time, twice a day. In case of severe oral thrush, the mother can give the baby 3-4 times a day. How to use:
Mix medicine with 1⁄4 teaspoons (equivalent to 5ml) with cooled boiled water. Use a gauze to absorb the medicine and give it to the baby. Hold for about 20 minutes, then feed or breastfeed again. Note:
For infants and young children, after perioral symptoms have resolved, nystatin should be continued for at least 48 hours. If symptoms persist after 14 days of treatment, the diagnosis should be reconsidered.
Do not dilute the medicine too much as this can reduce the effectiveness of the drug.
2.2. Adults With powder medicine Nystatin package: 2 packs each time, 2 times a day. Usage is the same as for infants and young children.
With lozenges or suspension: 400,000-600,000 UI* 4 times/day.
For suspension, it should be shaken well before use and should be kept as long as possible. The goal is to get the drug in contact with the damaged site before swallowing.
2.3. Treatment of overdose The drug is not absorbed through the skin and mucous membranes, so overdose or accidental ingestion does not cause systemic toxicity.
If you accidentally swallow too much medicine down the digestive system, it can be treated by gastric lavage, then bleach and appropriate supportive treatment.
2.4. Treatment of missed dose Take the medicine as soon as you remember the missed dose.
In case of missed dose of nystatin with the next dose, skip the missed dose and take the medicine as scheduled.
Never use a double dose to make up for a missed dose.
3. Contraindications of the package Nystatin drug
Patients who are allergic to any ingredient or excipients of Nystatin sachets Caution should be exercised when using Nystatin sachets in patients with a rare hereditary disorder of fructose intolerance.
4. Notes when using the package of Nystatin medicine
Carefully read the instructions for use of the drug before use, especially the part on how to use the drug to promote the best effect. The drug loses its anti-Candida albicans effect if used concurrently with Riboflavin phosphate. No dessert after feeding, eating powder; do not brush your teeth carefully; often eat cakes and sweets at night.... Are the causes of thrush, stomatitis, so parents should note instructions for children to rinse their mouths or brush their teeth in the morning and evening, and then rinse their mouths later. while eating candy. Nystatin is not excreted in human milk. Subjects should not use or be cautious when using Nystatin oral thrush:
Subjects with a history of allergy to nystatin or any ingredient in the formula should not use it. In addition, some of the following cases also need to be cautious when using nystatin:
Nystatin contains sucrose. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or impaired sucrase-isomaltase activity should not take this medicine. This should also be borne in mind in patients with diabetes. Nystatin contains propyl p-hydroxybenzoate and methyl p-hydroxybenzoate which may cause allergic reactions. Nystatin contains sodium metabisulphite (E223) which may cause serious hypersensitivity reactions and bronchospasm (rare).
5. Side effects of the drug Nystatin pack
Side effects may vary from person to person.
Nystatin is almost non-toxic, non-sensitizing and well tolerated at all ages, including young children, and even with prolonged use.
Uncommon : Skin: Urticaria, rash.
Rare : Causes local irritation. Steven-Johnson syndrome.
Inform the doctor about the unwanted effects encountered when using the drug.
6. How to store Nystatin pills?
Store in a cool, dry place away from moisture, below 30°C, away from direct sunlight.
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