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Morphine 10mg/ml is an addictive analgesic with effects mainly on the intestines and central nervous system through the mu receptor in the dorsal horn of the spinal cord. The following article will introduce you to some information about Morphine 10mg/ml pain reliever.
1. What is Morphine 10mg/ml?
Morphine 10mg/ml pain reliever has the main active ingredient Morphine hydrochloride. It is an addictive analgesic with primary action on the intestines and central nervous system via the mu receptors in the dorsal horns of the spinal cord. Morphine 10mg/ml is readily absorbed from the gastrointestinal tract and mainly in the duodenum. Absorption capacity in the rectal mucosa is moderate. The drug is rapidly absorbed after intramuscular or subcutaneous injection and is particularly well absorbed into the spinal cord following external or intradural administration.
When entering the body, about 1/3 of Morphine is bound to plasma proteins. Morphine is not long-lived in tissues, so for about 24 hours after the last dose, concentrations are very low. Although the main site of action of Morphine is on the central nervous system, the ability to cross the blood-brain barrier is very low.
2. Effects of pain reliever Morphin 10mg/ml
Morphine exerts its main effects on the central nervous system through the mu receptor, including drowsiness, analgesia, mood swings, respiratory depression, decreased gastrointestinal motility, and changes in internal organs. vomiting, nausea, vomiting. In which:The analgesic effect is due to the mechanism of reducing pain perception and increasing pain threshold. On the central nervous system with manifestations such as strong inhibition of respiratory muscles, nausea and vomiting, neurological symptoms, pupillary constriction and antidiuretic hormone release. Morphine inhibits the respiratory center by inhibiting the excitability of CO2 on the respiratory center in the medulla oblongata. One of the most prominent effects of Morphine on mental health is euphoria, but people also become depressed or exhibit drowsiness, memory loss, and loss of concentration.
3. Indications of Morphine 10mg/ml pain reliever
Morphine 10mg/ml is indicated in the treatment of severe pain or unresponsiveness after using analgesics in the following cases:
Surgery; After trauma; End stage of cancer disease; Pain in obstetrics or used in combination in pre-anesthesia and anesthesia.
4. How to use Morphine 10mg/ml pain reliever
In adults:
Use by subcutaneous or intramuscular injection is usually 10mg with a frequency of 4 hours / time, in some cases it can range from 5 to 20mg. Administer slowly intravenously at a starting dose of 10 to 15 mg at a rate dependent on the patient's condition, usually 60 to 80 mg/24 hours. Epidural injection in surgery and obstetrics at doses from 0.05 to 0.10 mg/kg. At a dose of 10mg/ml Morphine epidural is used only for cancer patients who have become accustomed to the drug due to prolonged treatment. Intradural injection for direct central pain relief in acute pain at a dose of 0.02 - 0.03 mg/kg/day. For chronic pain, the dose is 0.015 - 0.15mg/kg/day. Depending on the condition, the dose may be increased up to 10 times. For children over 30 months old:
Use subcutaneously or intramuscularly at a dose of 0.1 - 0.2mg/kg and up to 15mg; May be repeated 4 hours apart. Intravenous administration equals 1/2 dose intramuscularly.
5. Contraindications of Morphine 10mg/ml
Some contraindications to the use of Morphine 10mg/ml pain reliever include:
People with a history of hypersensitivity to any ingredient of the drug. Patients with severe liver failure, respiratory failure. The patient is suffering from brain injury or increased intracranial pressure. Symptoms of acute abdominal pain of unknown cause. Children under 30 months old. People who are using drugs belonging to the MAO group.
6. Some notes when using Morphine 10mg/ml
It should be noted not to use Morphine at the same time with the following drugs:
MAO group; Antihistamine H1; Morphine derivatives, Benzodiazepines, Barbiturates, Neuroleptic, Clonidine. Some possible side effects when using this drug include:
Nervous suppression; Nausea and vomiting; Increased secretion of antidiuretic secretory hormones, urinary retention; Constipation ; Pupil contraction. Caution should be exercised when used in cases of pregnant or lactating women.
The article has provided information on uses, dosage and notes when using Morphine 10mg/ml pain reliever. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Morphine 10mg/ml exactly as directed by your doctor.
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