This is an automatically translated article.
Mixatine is an antimalarial drug, with the main ingredients being Artesunate 50mg and Amodiaquine 153mg. The drug is in the form of round tablets. For more detailed information about Mixatine drug such as uses and usage, you can refer to the article below.
1. What is Mixatine?
Active ingredient Amodiaquine is a derivative of 4-aminoquinolein, which has the effect of killing schizophrenia in red blood cells of all 4 strains of Plasmodium falciparum, it is also effective against Plasmodium falciparum strains sensitive to chloroquine and some other strains resistant to chloroquine. chloroquine.
The mechanism of antimalarial action of amodiaquine is unknown but may be due to amodiaquine concentration, in the lysosomes of the malaria parasite, and loss of lysosome function. Mixatine affects the digestion of hemoglobin and reduces the energy supply to the parasite.
Active ingredient Artesunate has the main effect of killing P. falciparum schizonts in the blood. Mixatine against malaria is mainly due to the presence of endoperoxide bridge in the structural formula. This active substance adheres tightly to the red blood cell membrane containing the malaria parasite and reacts with the hematin in the parasite. At the same time, Artesunate also inhibits the production of oxidizing enzymes in erythrocytes or inhibits the activity of these enzymes that degrade the red blood cell membrane due to highly active oxidant radicals.
2. Indications for use of Mixatine
Mixatine is indicated for use in the following cases:
Severe malaria Cerebral malaria caused by Plasmodium falciparum, Contraindicated to use Mixatine in the following cases:
The patient is allergic to amodiaquine, artesunate, or contraindicated ingredients. production of artemisinin contained in Mixatine or other excipients. Patient has liver disease. Women in the first trimester of pregnancy.
3. Notes when using Mixatine
Because Mixatine contains the active ingredient amodiaquine, it should not be used to prevent malaria caused by Plasmodium falciparum, which may cause some side effects on the liver, agranulocytosis.
When the patient takes a dose of Mixatine greater than the recommended dose, it may cause neurological disorders such as: unconsciousness, spasms, convulsions, movement disorders. Therefore, you need to strictly follow the instructions of the specialist, avoid overdose or arbitrarily change the dose of the drug without being examined.
In addition, the component Amodiaquine can cause blood disorders: hemolytic anemia, liver, peripheral nervous system. When taking long-term, frequent doses, it is necessary to periodically check vision.
4. Mixatine drug interactions
Other antimalarial drugs when combined with Mixatine will increase the rate of agranulocytosis. Concomitant use of chloroquine with Mixatine may cause movement disorders. Magnesium trisilicate and kaolin may reduce the gastrointestinal absorption of Mixatine when used in combination.
5. Dosage and how to use Mixatine
Adults and children over 13 years old: Take 2 tablets/time x 2 times/day, use for 3 days. Children from 7 to 13 years old: take 1 tablet/time x 2 times/day, use for 3 days. Children from 1 to 6 years old: take 1 tablet/time/day for 3 days. When using an overdose of Mixatine, you may experience signs of: unconsciousness, somnolence, spasticity, convulsions, loss of coordination of movement,... More severe manifestations: cardiovascular disorders, convulsions , coma, hypotension, shortness of breath, cardiac arrest, hypokalemia, especially visual disturbances, decreased visual acuity can lead to blindness.
Immediately notify the doctor or go to the nearest hospital for timely monitoring and treatment.
6. Mixatine side effects
Mixatine can cause some side effects such as:
Blood disorders Liver dysfunction Peripheral neuropathy Digestive disorders: causing nausea, vomiting, diarrhea Itching, allergic pain Pain Headache, dizziness, dizziness Visual disturbances There may be side effects mentioned above that have not been listed, so during the use of Mixatine, if you experience any unusual signs, please inform your doctor immediately.
In short, Mixatine is a drug to treat malaria, you need to be consulted, examined and prescribed by a doctor. Avoid self-medicating without being examined to limit side effects and adverse interactions.
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