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Midataxim 0.75g belongs to the group of anti-parasitic, anti-infective, anti-viral and fungal drugs. It is used to treat severe infections caused by susceptible organisms in both adults and children. Below is detailed information about what drug Midataxim 0.75g is and what to watch out for when using it.
1. What is Midataxim?
Middataxim drug is prepared in the form of a powder for injection, with the main ingredient being Cefotaxime (in the form of Cefotaxime sodium) with the content of 0.75g.
Cefotaxime is a broad-spectrum antibiotic belonging to the 3rd generation cephalosporin group.
The bacteria sensitive to Cefotaxime: Enterobacter, Escherichia coli, Shigella, Salmonella, Proteus vulgaris, Proteus mirabilis, Providencia,, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii , Staphylococcus, Streptococcus, Haemophilus influenzae, Haemophilus spp., Neisseria (including N. meningitidis, N. gonorrhoeae), Branhamella catarrhalis, Peptostreptococcus, Clostridium perfringens, Borrelia burgdorferi, Aeromonas hydrophila. Bacteria resistant to cefotaxime: Enterococcus, Listeria, methicillin-resistant Staphylococcus, Pseudomonas cepiacia, Xanthomonas maltophilia, Clostridium difficile, Gram-negative anaerobes.
2. Uses of Midataxim 0.75g
Midataxim 0.75g drug is used in cases of severe infections caused by susceptible bacteria in both adults and children such as:
Sepsis, endocarditis; Brain abscess ; Meningitis (except meningitis caused by Listeria monocytogenes); Pneumonia , gonorrhea , typhoid ; Severe intra-abdominal infections (in combination with metronidazole); Prophylaxis of infection after prostate surgery, including laparoscopic surgery, cesarean section. Do not use Midataxim 0.75g when there is a history of allergy to Cephalosporin and Lidocaine (if using preparations containing Lidocaine).
3. Dosage and how to use Midataxim 0.75g
Dosage depends on each subject:
Adults: 2 - 6g/day, divided 2-3 times/day. In case of severe infection, the dose can be increased to 12g/day, intravenous infusion 3-6 times/day. Blue pus bacilli are used at a dose of more than 6g/day. Children: 100 - 150 mg/kg/day (infants use 50 mg/kg/day), divided into 2-4 times. In severe infections, the dose may be increased to 200mg/kg/day (in neonates 100-150 mg/kg/day). Dosage should be reduced in patients with severe renal impairment (creatinine clearance <10 ml/min). After the first loading dose, reduce the dose by half but keep the same number of doses in 1 day. The maximum dose is 2g/day. Treatment of infections caused by group A beta-hemolytic streptococci should be used for at least 10 days. Persistent infections can last for weeks. Treatment of gonorrhea: Use 1g single dose Prevention of infection after surgery: 1g injection 30 - 90 minutes before surgery. Caesarean section, 1g intravenously to the mother after clamping the vegetable stalk, then 2 more doses at 6 and 12 hours later (intramuscular or intravenous). How to use:
Deep intramuscular injection or slow intravenous injection for 3-5 minutes: Dissolve 0.75g of the drug with 3ml of distilled water for injection or 3ml of 1% lidocaine hydrochloride (only for intramuscular injection for adults). Slow intravenous infusion over 20 - 60 minutes: Mix 1.5g of the drug in 40 - 60 ml of one of the following fluids: 0.9% sodium chloride, 5% dextrose or intravenous solution with a pH of 5 - 7.
4. Side effects of the drug Midataxim 0.75g
When using the drug Midataxim may experience some undesirable effects as follows:
At injection site: painful swelling at the site of intramuscular injection, thrombophlebitis; Digestive disorders: abdominal pain, nausea, vomiting, diarrhea, pseudomembranous colitis; Hypersensitivity reactions, anaphylaxis; Thrombocytopenia, agranulocytosis, eosinophilia, hemolytic anemia; Increase liver enzymes. When using Midataxim, if the patient experiences any serious side effects, stop taking the drug and contact the treating doctor or immediately go to a medical facility for timely treatment.
5. Interactions with drugs Midataxim
When using at the same time Midataxim may interact with some of the following drugs:
Co-administration with colistin antibiotics increases the risk of kidney damage. Cefotaxime increases the nephrotoxicity of cyclosporin. Concomitant administration of cefotaxime with azlocillin may increase the risk of encephalopathy and partial seizures when used in patients with renal impairment.
6. Notes and cautions when using the drug Midataxim
When using Midataxim, caution should be exercised in the following cases:
Cefotaxime should not be mixed with other antibiotics in the same syringe or intravenous infusion set. Before initiating treatment with Cefotaxime, the patient's history of allergy to Cephalosporins, penicillins or other drugs should be carefully investigated. If used in combination with potentially nephrotoxic drugs (Aminoglycosides), it is necessary to closely monitor the patient's renal function. Cefotaxime may interfere with the results of some laboratory tests such as false positives for the Coombs test, urine tests and non-enzymatic reducing agents. The safety of the drug in pregnant women has not been established, the drug can cross the placenta during the second trimester of pregnancy and is excreted in breast milk in nursing women. Therefore, caution should be exercised when using these objects. In summary, Midataxim is used for the treatment of severe infections caused by susceptible organisms in both adults and children. In addition to the above information, if you have any questions about Midataxim, you can contact your doctor for advice and answers.
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