Uses of Midancefe

This is an automatically translated article.

1. What is Midancef 125?

Pharmaceutical name: Midancef 125 Classification: Drugs Registration number: VD-21322-14 Drug group: Antiparasitic, anti-infective, antiviral, antifungal drugs Manufacturer: SaVi Pharmaceutical Joint Stock Company Ingredients: Midancef 125 medicine contains the main ingredient is Cefuroxim (in the form of Cefuroxim axetil) 125mg other active ingredients and excipients with just enough drug content provided by the manufacturer. Dosage form: Film-coated tablets Packing: Box of 1 bag x 1 blister x 10 tablets Content: Need to look carefully at the drug form and strength stated on the product packaging or in the instruction sheet for exact information drug form and content in the product.

2. Uses of Midancef

Effects
What does Midancef 125 do?
Cefuroxime is a semi-synthetic broad-spectrum antibiotic, belonging to the cephalosporin group, sodium salt injection, oral axetil ester. Cefuroxime axetil is a prodrug of cefuroxime, which has little antibacterial activity when it is not hydrolyzed to cefuroxime in the body after absorption. Cefuroxime has antibacterial activity by inhibiting bacterial cell wall synthesis by binding to essential target proteins (penicillin-binding proteins). Resistance can be caused by bacteria secreting cephalosporinase enzymes, or by alteration of penicillin-binding proteins. Cefuroxime has a very specific and effective antibacterial activity against many common pathogens, including beta-lactamase/cephalosporinase-producing strains of both gram-positive and gram-negative bacteria. Cefuroxime is particularly resistant to many beta-lactamase enzymes of gram-negative bacteria.
Each type of pharmaceutical product is primarily used to treat a specific disease or condition. Therefore, only use Midancef 125 to treat the conditions or conditions specified in the instructions for use. Although Midancef 125 may have some other effects that are not listed on the approved label, you should only use this medicine to treat certain other conditions when directed by your doctor.
Indications
Lower respiratory tract infections such as pneumonia and acute and chronic bronchitis. Upper respiratory tract infections such as ear, nose and throat infections such as otitis media, sinusitis, tonsillitis and pharyngitis. Genitourinary infections such as pyelonephritis, cystitis, urethritis. Skin and soft tissue infections such as boils, pustules, impetigo. Gonorrhea, such as acute uncomplicated gonococcal urethritis and cervicitis. Dosage and usage
Adults:
In bronchitis and pneumonia 500mg x 2 times/day. In most infections: 250mg twice daily. In urinary tract infections, a dose of 125mg x 2 times/day is used. Uncomplicated gonorrhea: 1g single dose Children:
The usual dose is 125mg x 2 times/day or 10mg/kg x 2 times/day. Maximum dose is 250mg/day. Children over 2 years old with otitis media: 250mg x 2 times/day or 15mg/kg x 2 times/day, up to a maximum of 500mg/day. Dosage of Midancef 125 for Adults
Dosage regulations are usually intended to guide adult subjects for oral administration. Dosage for other routes is specified in the leaflet. Do not change the dose on your own without consulting your doctor or pharmacist.
Dosage of Midancef 125 for children
Differences between children and adults such as pharmacokinetics, pharmacodynamics, side effects... especially children are not allowed to be tested. clinical practice before granting marketing authorization for a new drug. Therefore, using this drug for children should be very careful even with drugs that have not been warned.
Overdose, missed dose, emergency
Overdose:
In case of emergency or overdose with dangerous manifestations, call 911 Emergency Center or go to the nearest local Health Facility. Relatives need to provide the doctor with the prescription they are taking, the medicines they are taking, including prescription and non-prescription drugs.
Missed dose:
In case you miss a dose while taking the medicine, take it as soon as possible (usually it can be taken 1-2 hours before the time ordered by the doctor). However, if it is almost time for your next dose, skip the missed dose and take your next dose at the prescribed time. Be careful not to double the prescribed dose.

3. Note when using Midancef 125

Contraindications
Known hypersensitivity to cephalosporin antibiotics. Note
Precautionary notes before taking Midancef 125
Generally, cephalosporin antibiotics can be safely administered to penicillin-sensitive patients, although there have been some reports of cross-reactivity. Particular care should be taken when administering to patients who have experienced anaphylaxis to penicillins. As with other antibiotics, long-term use of cefuroxime axetil may lead to proliferation of non-susceptible organisms (Candida, Enterococci, Clostridium difficile), in which case discontinuation may be necessary. Pseudomembranous colitis has been reported with broad-spectrum antibiotics; therefore, it is important to consider the diagnosis in patients with severe diarrhea during or after antibiotic use. Glucose oxidase or hexokinase methods are recommended for the determination of blood or plasma glucose concentrations in patients receiving cefuroxime axetil. This antibiotic does not affect the alkaline picrate test for creatinine.
Precautions for taking Midancef 125 during pregnancy
Not known if it is toxic through breastfeeding. It is best not to or limit the use of the drug during breast-feeding. Many drugs have not yet fully determined the effects of the drug during this period, so you need to carefully read the instructions for use and consult your doctor, pharmacist before deciding to use the drug.

4. Side effects of Midancef 125

In general, the adverse effects caused by cefuroxime axetil are usually mild and last only a short time.
A small number of patients taking cefuroxime axetil have experienced gastrointestinal disturbances, including diarrhea, nausea, and vomiting. As with broad-spectrum antibiotics, there have been a few (very rare) reports of pseudomembranous colitis. Headache has also been reported. Eosinophilia and transient elevations of liver enzymes [ALT(SGPT) and AST (SGOT)] have been observed during treatment with Zinnat.
A positive Coombs reaction has been reported during treatment with cephalosporins; This phenomenon may interfere with blood cross testing.
It should be noted that the above is not a complete list of all the side effects of Midancef 125. During use, there may be other side effects that have not been shown or have not been studied. If there are any other side effects of Midancef 125 that are not specified in the instructions for use, consult your doctor or pharmacist.

5. Drug interactions

When using two or more drugs at the same time, it is easy to have drug interactions leading to antagonism or synergism.
Drug interactions Midancef 125 with other drugs
Decreased effect: ranitidine and sodium bicarbonate reduce the bioavailability of cefuroxime axetil. Cefuroxime axetil should be administered at least 2 hours after antacids or H2 blockers, as these may increase gastric pH.
Increased effect: High dose probenecid reduces renal clearance of cefuroxime, resulting in higher and more prolonged plasma concentrations of cefuroxime. Increased toxicity: aminoglycosides increase the potential for nephrotoxicity.
Midancef 125 drug interactions with food and drinks
When using drugs with foods or alcohol, beer, tobacco... because in those foods and drinks contain other active ingredients, there should be other active ingredients. may affect the phenomenon of antagonism or synergy with the drug. Read the instructions for use carefully or consult your doctor or pharmacist about taking Midancef 125 with food, alcohol and tobacco.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.