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The drug Mezamazol belongs to the list of drugs to treat hyperthyroidism, with the main ingredient being Thiamazol. The drug is used for symptomatic treatment of hyperthyroidism, as adjuvant therapy before thyroid surgery, as adjunct to treatment before and during radiation therapy, and episodes of hyperthyroidism prior to administration of iodized salt.
1. What is Mezamazol?
Mezamazol is a modern medicine manufactured by Ha Tay Pharmaceutical Joint Stock Company. The drug is indicated for the treatment of hyperthyroidism. Mezamazol drug is prepared in tablet form, with the main ingredient is Thiamazol and each tablet contains 5mg Thiamazol. Packing is box of 10 blisters x 10 tablets.
2. What are the uses of Mezamazol?
Mezamazol drug has the main ingredient Thiamazol - a synthetic antithyroid drug. Thiamazol has the effect of inhibiting the self-synthesis of thyroid hormone in the thyroid gland by acting as a substrate for the thyroid peroxidase enzyme, in order to limit this enzyme from catalyzing the Tyrosin radical of Thyroglobulin with the oxidized and reactive iodine. converts Iodotyrosine to Iodothyronine, causing the iodine to go wrong in the thyroid hormone production process in the thyroid gland. In addition, Thiamazol also does not inhibit the effect of thyroid hormone in the thyroid gland or in the circulation, and does not inhibit thyroid hormone release and does not affect the effectiveness of thyroid hormone taken from outside. Therefore, thiamazol is not effective in thyrotoxicosis when overdosed with thyroid hormone.
In addition, Thiamazol does not cure the cause of hyperthyroidism and is not usually used long-term to treat hyperthyroidism.
3. How to use and dose Mezamazol
3.1 How to take the drug Mezamazol is made in tablet form and used by direct oral administration, 3 times a day, 8 hours apart, or it can also be taken 1-2 times a day depending on the severity of the disease and the ability to take it. drug absorption. However, when using a low dose or taking fewer doses, the effect can be reduced, but the possibility of side effects is less so patients can also consider using a low dose.
Especially if in the case of having to use radioactive iodine therapy, the patient must stop using the drug from 2-4 days or maybe longer from 3-7 days to avoid affecting the effectiveness of this therapy. .
In addition, to achieve the desired therapeutic effect, at least the patient needs to use Mezamazol continuously for a period of 6 months or more.
3.2 Recommended dosage Depending on the severity of the disease and age, the recommended dosage will vary.
Teenagers and adults:
Treatment of hyperthyroidism:
Initial dose:
Mild hyperthyroidism: Take 15 mg/day, divided equally into 3 oral doses, 8 hours apart; Moderate hyperthyroidism: Take 30-40 mg/day, divided equally into 3 doses, each time taking 8 hours apart; Severe hyperthyroidism: Take 60 mg/day, divided equally into 3 oral doses, each time taking 8 hours apart; Maintenance dose: Take 5 - 15 mg / day, divided equally into 3 times, each time taking 8 hours apart.
Continuously taking the initial dose for 1-2 months, the symptoms of hyperthyroidism will be relieved, you can reduce the oral dose to the maintenance level.
Thyrotoxicosis
Maintain oral 15 - 20 mg/day, once every 4 hours in the first day, and should be combined with other therapies for better effect. In addition, the dose may be adjusted according to the individual's ability to respond to the drug.
Children
Hyperthyroidism
Initial dose: Oral 0.4 mg/kg/day (400 micrograms/kg/day), divided equally into 3 oral doses and each time taken 8 hours apart. Maintenance dose: Oral 0.2 mg/kg/day (200 micrograms/kg/day) divided equally into 3 oral doses and each time taken 8 hours apart. The above dosage is for reference only, so to get the right dose, it is best to consult a doctor or a qualified pharmacist.
4. Notes when using Mezamazol
Before using the drug, the patient should carefully read the instructions for use and the product information printed on the box.
4.1 Indications Mezamazol is usually indicated for the following cases:
Supportive treatment of symptoms of hyperthyroidism (including Graves - Basedow's disease). Treat before thyroid surgery for hyperthyroidism, until basal metabolic activity is normal, to prevent a bout of thyrotoxicosis that may occur when the thyroid is partially removed. Supportive treatment before and during radioactive iodine therapy (131I) until radioiodine therapy is able to remove the thyroid gland. Treat thyrotoxicosis before iodized salt. Usually Mezamazol will be used concurrently with a beta-blocker, especially when there are accompanying cardiovascular symptoms such as tachycardia, .... 4.2 Contraindications Mezamazol is contraindicated for one of the following: The following cases:
People who are hypersensitive to Thiamazol components of the drug Patients with severe liver and kidney failure. People who are suffering from some blood diseases such as (agranulocytosis, marrow failure,...). Pregnant and lactating women. 4.3 Precautions for use Only use the drug exactly as prescribed by the treating doctor, do not arbitrarily increase or decrease the dose in any case if the doctor does not specify.
Patients need to monitor the white blood cell count and white blood cell count weekly before and after using the drug for the first 6 months, because Mezamazol can cause the white blood cell count to decrease, especially in elderly patients or people. frequent use of high doses of 40 mg/day or more.
On the other hand, Thiamazol can cause harm to the fetus and young child such as hypothyroidism and goiter. Therefore, pregnant and lactating women should not use it.
5. Side effects when taking Mezamazol drugs
Some unwanted side effects that may occur when taking Mezamazol are:
Common: Agranulocytosis, skin rash, itching, hair loss, mild fever, headache. Uncommon: Tachycardia, high fever, pharyngitis, hoarseness, nausea, loss of taste, musculoskeletal pain, cough, peripheral nerve pain,... Rare: Thrombocytopenia, marrow depression, bruising purple skin, hemorrhage, nephritis, interstitial pneumonia, hepatitis, cholestatic jaundice,... If you see any side effects in your body, contact your doctor immediately for instructions and treatment. handle quickly.
6. Mezamazol drug interactions
Some interaction reactions of Mezamazol when used with other drugs, patients need to pay attention to are:
Theophylline, Oxtriphylline, Cardiac Glycoside, Aminophyllin, Beta-blockers with pharmacokinetic changes, so the dose should be reduced when Thiamazol treatment. Iodine-containing drugs such as Iodine, Amiodarone, need to increase the dose of Thiamazol. Indandion, Coumarin derivatives anticoagulants, when used with Thiamazol, can reduce blood prothrombin. Radioactive iodine salts: Thiamazol reduces the absorption of iodine into the thyroid gland, so if you stop using Thiamazol suddenly for 5 days, it will lead to an increase in Iodine absorption. For your own safety, tell your doctor about all the medicines you are taking.
7. How to handle overdose, forget dose of Mezamazol
Mezamazol is a new drug, so when overdosed, it will cause some complications and unwanted side effects. Therefore, when taking an overdose, the patient needs to be stimulated to vomit or perform gastric lavage. In case the patient is comatose, has a convulsion, after gastric lavage, an endotracheal tube can be placed or given antibiotics and blood transfusion if necessary.
Conversely, if you miss a dose, take it as soon as possible, but if it is close to the next dose, you can skip the missed dose and take the next dose as indicated. Never take a supplement by doubling the dose at the next dose.
Mezamazol drug belongs to the list of drugs to treat hyperthyroidism, with the main ingredient being Thiamazol. The drug is used for symptomatic treatment of hyperthyroidism, as adjuvant therapy before thyroid surgery, as adjunct to treatment before and during radiation therapy, and episodes of hyperthyroidism prior to administration of iodized salt. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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