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Ursodeoxycholic Acid salt is indicated quite commonly in the treatment of liver disorders, gallstones, cirrhosis, liver abnormalities... This is also the main active ingredient present in Meyerursolic 300mg.
1. Uses of Meyerursolic 300mg
What is Meyerursolic 300mg? Meyerursolic medicine 300mg has the main active ingredient is ursodeoxycholic acid 300mg content. Meyerursolic 300mg is manufactured at Meyer - BPC - Vietnam Joint Venture Company.
Ursodeoxycholic acid is a natural bile salt present in very low concentrations in the body, which is different from other endogenous bile salts. The property of ursodeoxycholic acid is very hydrophilic and has no detergent effect.
Ursodeoxycholic acid has an effect on the hepato-enteric cycle of endogenous bile acids, thereby increasing the secretion of bile, reducing the reabsorption of bile by inhibiting active reabsorption in the intestine. decrease the concentration of endogenous bile acids in the blood.
Ursodeoxycholic acid is one of the measures to treat gallstones of a cholesterol nature to help reduce cholesterol levels in bile. This effect of ursodeoxycholic acid is a combination of several different mechanisms:
Decreased cholesterol reabsorption; Increases hepatic metabolism of cholesterol into bile acids through a pathway that increases the hepatic activity of the cholesterol enzyme 7alpha-hydroxylase; Ursodeoxycholic acid maintains cholesterol in soluble form in bile.
2. Indications of Meyerursolic 300mg
Meyerursolic 300mg helps improve liver function in chronic hepatitis; Meyerursolic medicine 300mg helps to protect and restore liver cells before or after drinking alcohol; Treatment of dyspepsia , loss of appetite due to the influence of biliary tract disorders; Meyerursolic medicine 300mg helps to support the treatment of cholesterol gallstones, cholecystitis, inflammation of the biliary tract.
3. Dosage and how to use Meyerursolic 300mg
Meyerursolic medicine 300mg is taken after meals with the following dosage:
3.1. Meyerursolic 300mg for the treatment of cholesterol gallstones Meyerursolic 300mg dose is effective from 5 to 10 mg/kg/day, the average recommended dose is 7.5 mg/kg/day in patients with moderate physical condition. For obese patients, the recommended dose of Meyerursolic 300mg is 10mg/kg/day, depending on body weight, the dose is from 2 to 3 tablets/day, taken once in the evening or divided Meyerursolic 300mg into two sessions. morning and evening. Treatment duration of Meyerursolic 300mg is usually 6 months, however, if the stone is larger than 1cm, the treatment time can be extended up to 1 year. 3.2. Treatment of Chronic Hepatobiliary Diseases Meyerursolic 300mg dose is 13-15mg/kg/day, patients should start at 200mg/day then increase Meyerursolic 300mg dose in increments to achieve optimal therapeutic dose in about 4 to 8 weeks of treatment. In case of acquired hepatobiliary disease due to viscous mucus disease, the optimal therapeutic dose of Meyerursolic 300 mg is 20 mg/kg/day. How to use: Divide Meyerursolic 300mg into 2 times, take morning and evening, drink with meals.
4. Contraindications of Meyerursolic 300mg
Hypersensitivity to the ingredients of the drug Meyerursolic 300mg. The patient has a bile duct obstruction. Pregnant.
5. Drug interactions of the drug Meyerursolic 300mg
Do not use Meyerursolic 300mg drug concurrently with the active ingredient cholestyramine because the effect of ursodeoxycholic acid will be reduced by binding to cholestyramine and being eliminated. . Do not use Meyerursolic 300mg with estrogens because these drugs will cause an increase in bile cholesterol. Avoid using Meyerursolic 300mg with other bile acid-binding drugs such as antacids, activated charcoal because it can reduce the effectiveness of treatment.
6. Meyerursolic 300mg side effects
Due to very poor intestinal solubility, ursodeoxycholic acid contained in Meyerursolic 300mg drug does not irritate the intestinal mucosa, so cases of diarrhea when taking the drug are very rare. Since Meyerursolic 300 mg increases pruritus and urticaria at the start of treatment for severe cholestasis, the recommended starting dose for these patients is 200 mg/day. Inform your doctor about the unwanted effects encountered when using Meyerursolic 300mg. For long-term Meyerursolic 300mg drug therapy, although ursodeoxycholic acid is not carcinogenic, rectal monitoring is recommended.
Usually these side effects or unwanted effects will go away when you stop taking Meyerursolic 300mg. If you have any rare side effects that are not mentioned in the Meyerursolic 300mg package insert, tell your doctor or healthcare provider right away if you suspect a side effect of Meyerursolic.
7. Use Meyerursolic 300mg with caution
In case of treatment of cholesterol gallstones, the therapeutic effect of Meyerursolic 300mg should be checked by imaging after 6 months.
In the treatment of chronic hepatobiliary disease with Meyerursolic 300mg:
Patients with cirrhosis combined with impaired liver function or cholestasis (blood bilirubin > 200 micromol/L), liver function and plasma concentrations of Bile acids must be monitored; In cases of cholestasis causing pruritus, the dose of ursodeoxycholic acid should be gradually increased with an initial dose of 200 mg/day. In this case, the concomitant use of Meyerursolic 300 mg with cholestyramine is necessary provided that cholestyramine must be administered 5 hours apart from Meyerursolic 300 mg. Animal studies have shown teratogenic potential; however, there are insufficient data to evaluate the teratogenicity or fetotoxicity of Meyerursolic 300 mg when administered during pregnancy. However, it is preferable not to use ursodeoxycholic acid during pregnancy except for very limited and validated indications.
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