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Mexold plus is a combination pain reliever used to relieve symptoms of mild to moderate pain. To learn more about the use of the drug, please refer to the information about the drug through the article below.
1. What are the uses of Mexold plus?
The main ingredients of Mexold are Acetaminophen (paracetamol) 500mg and Caffeine 65mg. Prepared in the form of tablets.Paracetamol Has analgesic - antipyretic effect. The drug works by acting on the hypothalamus causing hypothermia, increased heat release due to vasodilation and increased peripheral blood flow. Due to the effect on the enzyme cyclooxygenase and the production of prostaglandins by the central nervous system, it has an analgesic effect. However, unlike non-steroidal anti-inflammatory drugs, Paracetamol has no effect on platelets or bleeding time, nor does it have almost any anti-inflammatory effect.
Paracetamol has the effect of lowering body temperature in febrile patients but rarely lowers body temperature in normal people. When used in excess, the drug will produce a metabolite called N-acetyl-benzoquinonimin, causing severe toxicity to liver cells.
Caffeine Caffeine has a stimulant effect on the central nervous system. Caffeine inhibits the enzyme phosphodiesterase and has an antagonistic effect at the central adenosine receptor. In addition, when taking caffeine can stimulate the respiratory center. This substance is combined with low doses with oral pain relievers such as aspirin, paracetamol to increase the analgesic effect of this drug.
2. Indications and contraindications of the drug Mexold Plus
2.1. Indications Mexold Plus is indicated for use in the following cases:
Treatment of mild to moderate pain symptoms such as: Headache, toothache, backache, muscle pain, menstrual pain, rheumatic pain joint. When used alone, Paracetamol has no effect or is less effective. Reduce mild to moderate fever in cases of fever caused by viruses, bacteria... 2.2.Contraindications Mexold Plus is not indicated in the following cases:
Patients are sensitive to the main ingredients paracetamol, caffeine or any of the excipients of the drug. The patient suffered from anemia several times. Heart disease, lung disease, liver failure, severe kidney failure Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Children under 12 years old do not use.
3. Dosage and how to use the drug Mexold Plus
How to use: The drug is taken with a full glass of water. Patients can take it with or without food. The dose may be repeated after 4-6 hours if necessary.
Dosage:
Adults and children 12 years and older: Take 1-2 tablets and 2-3 times a day. Do not take more than 8 tablets/day. Or calculate dose by weight 10-15mg Paracetamol/kg body weight. Do not use paracetamol-containing medicines for pain relief for more than 10 days in adults or more than 5 days in children, unless its use is directed by a physician. Do not use paracetamol for adults and children to self-treat high fever, fever lasting more than 3 days or recurrent fever, should find the cause for effective treatment.
4. Overdose and missed dose of Mexold Plus
Overdose:
Paracetamol: When overdose can cause symptoms such as nausea, vomiting, abdominal pain, loss of appetite, increased methemoglobinemia leading to cyanosis of the skin, mucous membranes and nails. Children tend to make methemoglobin more easily than adults after taking paracetamol. Treatment: Gastric lavage in all cases of paracetamol poisoning, preferably within 4 hours after ingestion. Treatment with N-acetylcysteine is the main antidote, must be taken immediately within 36 hours and more effective within 10 hours after taking paracetamol. Give oral N-acetylcysteine with the first dose of 140 mg/kg, then continue to take another 17 doses, each dose of 70 mg/kg every 4 hours. Treat with methionine in the absence of N-acetylcysteine, start treatment within 10-12 hours after taking paracetamol, with an initial oral dose of 2.5g, followed by 2.5g every 4 hours. g, drink about 3 times. It is necessary to treat quickly and early because if it is late, it can cause irreversible liver failure. Caffeine: Caffeine overdose is very rare. Possible symptoms include: Fever, rapid breathing, restlessness, insomnia, tachycardia, tremors of the extremities, convulsions. Management: Treatment should be symptomatic and supportive. Missed dose:
If you miss a dose, you can skip the missed dose and take your next dose at the next time.
5. Side effects of the drug Mexold Plus
If the patient uses the drug Mexold Plus at the right dose and does not abuse it, it will cause less side effects. However, there are still some cases of unwanted side effects:
For Paracetamol
Skin rash and allergic reactions rarely occur, usually erythema or urticaria, but sometimes can more severe and may be accompanied by drug fever, mucosal lesions. In rare cases, paracetamol causes neutropenia, thrombocytopenia and pancytopenia. Less commonly, it can cause nausea, vomiting, headache, insomnia, kidney disease, nephrotoxicity with long-term abuse. Rare but serious: May cause hypersensitivity reactions, serious skin reactions such as Stevens-Johnson syndrome (SJS), Lyell's syndrome, acute generalized exanthematous pustulosis (AGEP), Toxic necrosis syndrome (TEN) For caffeine:
Common side effects of caffeine include: Insomnia, nervousness, anxiety, irritability, headache, digestive disorders. Rare serious side effects such as anaphylaxis include rash, itching or swelling (especially of the face, tongue, and throat), dizziness, difficulty breathing, and chest pain. When experiencing side effects of the drug, especially serious side effects, you need to stop using and notify your doctor or go to the nearest medical facility for timely treatment.
6. Notes when using the drug Mexold Plus
This is a medication for symptoms and is not a substitute for medications to treat the cause. So if you take medication that doesn't improve, you need to see a doctor to find out the cause of the pain or fever. Use with caution in patients with anemia because cyanosis may not be evident. Although having high blood levels of methemoglobin is dangerous. Avoid alcohol during treatment with paracetamol-containing medicines because both substances are harmful to the liver, increasing the risk of hepatotoxicity. Pregnancy: Currently, there are no recorded adverse effects in pregnant women when using paracetamol. However, caffeine is a substance that can cross the placenta and cause fetal abnormalities when used in very high doses. Therefore, be careful when using this drug for pregnant women. Lactation: Because caffeine can pass into breast milk, there have been no reports of unusual effects on nursing infants. However, extreme caution should still be exercised when this preparation is administered to a nursing woman. Do not use multiple drugs with similar effects and ingredients together, as the risk of toxicity and overdose increases. Avoid taking the drug at the same time with foods and drinks containing caffeine because it increases the side effects of caffeine.
7. Drug interactions
Attention must be paid to the risk of severe hypothermia in patients receiving concomitant phenothiazines and antipyretic therapy. Anticonvulsants such as phenytoin, barbiturates, carbamazepine: increase the metabolism of paracetamol into substances that are toxic to the liver. Co-administration with isoniazid also causes increased hepatotoxicity. Oral contraceptives: This medication may decrease the hepatic metabolism of caffeine. Thereby reducing the clearance and increasing the half-life of caffeine, while increasing the effects of caffeine. Storage: Should be stored below 30°C, dry, protected from moisture and light. Keep medicine out of reach of children and pets.
Hopefully, with the above information, you already know what the drug Mexold plus is and how to use it to achieve the highest efficiency.
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