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Meshanon drug belongs to the group of muscle relaxants and increases muscle tone, indicated for the treatment of myasthenia gravis and constipation caused by intestinal motility disorders. So how is Meshanon used?
1. What is Meshanon?
Meshanon medicine contains the main ingredient Pyridostigmine bromide, the content of 60mg and other excipients just enough provided by the manufacturer. The drug is prepared in the form of tablets, packing box of 3 blisters, each blister has 10 tablets.
2. What is the effect of Meshanon?
Meshanon is indicated for the treatment in the following cases:
Treatment of myasthenia gravis. Support for the treatment of constipation in patients with bowel movement disorders due to Parkinson's disease. On the other hand, Meshanon is contraindicated in the following cases:
Allergy to the active ingredient Pyridostigmine bromide or other excipients in the composition of the drug. Mechanical obstruction of the urinary or gastrointestinal tract.
3. Dosage and how to take Meshanon
Meshanon is prepared in the form of tablets, used orally. The drug should be taken in the morning when getting up or during meals or about 30-45 minutes before eating. The drug should be taken with filtered or boiled water to cool, not with other drinks containing alcohol. In case the patient has difficulty swallowing, the tablet can be broken in half to drink.
The following is the recommended dose of Meshanon:
Treatment of myasthenia gravis:
Adults: Use at a dose of 1 - 3 tablets/time, 2 - 4 times/day, each dose at least 4 hours apart. . The effects of a single dose usually last 3 to 4 hours during the day and last longer than 6 hours when taken at bedtime. Children: dose from 5 to 10 mg / day, can be crushed tablet, use 30-45 minutes before eating. Relieve severe constipation in patients with dyskinesia due to Parkinson's disease:
60mg/time, 3 times a day. When patients overdose on Meshanon, symptoms such as abdominal cramps, increased intestinal motility, diarrhea, nausea, vomiting, increased salivation, pupillary constriction, muscle weakness, hypotension, and discontinuation usually occur. heart. When detecting the above signs of overdose, the patient should stop taking the drug immediately, immediately take to the nearest medical facility for timely emergency. Atropin can be controlled with a dose of 2mg, intravenously, then intramuscularly, every 2-4 hours, depending on the doctor's prescription, avoiding an overdose of Atropin.
4. Meshanon side effects
Doctors always consider between the benefits that Meshanon brings to the patient and the possible risk of side effects to prescribe the appropriate medication. Patients need to follow the doctor's instructions to avoid unwanted effects. Meshanon is generally well tolerated, however, in the event that a patient develops any unusual symptoms that are suspected to be drug related, notify the doctor or pharmacist immediately.
Some unwanted effects when taking the drug are as follows:
Common:
Increased sweating, loss of appetite, bradycardia, nausea, vomiting, diarrhea, increased intestinal motility, abdominal pain, salivation , rhinitis, muscle paralysis, convulsions. Uncommon:
Dizziness, hypertension, hypotension, insomnia. Rare:
Skin rash, alopecia.
5. Meshanon drug interactions
Inform your doctor about all the medicines you are taking such as prescription drugs, over-the-counter drugs, functional foods, herbs... to avoid interactions that occur when taking a combination of drugs in treatment process.
Some drugs that may interact with Meshanon when used in combination are as follows:
Immunosuppressive drugs: The need for Meshanon drugs may be reduced when combined with steroids, immunosuppressive drugs despite the concentration. Peak plasma concentrations and AUC may be reduced with high doses of corticosteroids. Methylcellulose drugs and drugs containing methyl cellulose in the excipients may inhibit the complete absorption of the drug. Anti-muscarin drugs: Atropin and hyoscin antagonize the action of Meshanon. These drugs can reduce gastrointestinal motility, affecting the absorption of drugs. Muscle relaxants: When used in combination with Meshanon, it has an antagonistic effect on non-depolarizing muscle relaxants and may prolong the effects of some other depolarizing muscle relaxants such as Suxamethonium. Aminoglycoside antibiotics, local and systemic anesthetics, antiarrhythmic drugs and other drugs that interact with neuromuscular transmission may interact with Meshanon.
6. Some notes when using Meshanon
Meshanon should be used with caution in patients with epilepsy, bronchial asthma, bradycardia, recent coronary occlusion, parasympathetic hyperthyroidism, hyperthyroidism, cardiac arrhythmias or gastric ulcer. Avoid high doses in people with enlarged colon or reduced gastrointestinal motility. In some cases, patients taking drugs that last longer than the salt of Neostigmin, can cause episodes of increased acetylcholine secretion. When using Meshanon for the treatment of myasthenia gravis, it should be remembered that, with the same dose of anticholinesterase drugs, there can be different responses in individual muscle groups, such as causing weakness in this muscle group while at the same time causing muscle weakness. increase muscle strength in other muscle groups. It is necessary to monitor the patient's respiratory function when increasing the dose of the drug to ensure good respiratory function. Meshanon crosses the placenta and is excreted in breast milk, so it should be used with caution in pregnant and lactating women. Drugs with anticholinergic or atropin-like effects must be used with extreme caution, when the patient is also being treated with Meshanon because the symptoms of overdose may be masked, by Meshanon, or vice versa. , symptoms while taking this drug may be masked by atropine and atropine analogues. Above is information about uses, dosage and precautions when using Meshanon. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Meshanon exactly as directed by your doctor.
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