Uses of medicine Kupdina 100 mg

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1. What is Kupdina 100?

Kupdina 100 mg is often prescribed by doctors for patients to use in the following cases:
Treatment of fibrocystic breast disease: Danazol ingredients are effective in reducing tumors, reducing pain and reducing pain. discomfort caused by fibrocystic breast disease, due to changes in hormone levels in the body. Note: after stopping the drug, the above symptoms may return. Treatment of endometriosis: Because of hormonal changes, it leads to painful symptoms in endometriosis. Danazol is also used to relieve pain when the hormone of choice is not tolerated or is not effective. Do not use the drug in cases where surgery is required. Treatment of hereditary angioedema: The drug is used to prevent diseases that cause hereditary angioedema of the abdomen, larynx, and skin in both men and women.

2. Dosage and usage

For fibrocystic breast disease: Use dosage from 100 mg - 400 mg, divided into 2 doses per day depending on the response of the patient. Patients need to make sure during the use of the drug that they are not pregnant.
In most cases of drug use, breast pain or discomfort due to the disease will be significantly reduced during the first period of use and will completely disappear in the later stages of treatment. The duration of treatment will depend on the severity of the disease. For example, with tumors that require continuous treatment for 4-6 months.
In the treatment of endometriosis: The starting dose is 800mg/day divided into 2 doses. It is important to ensure that the patient is not pregnant when starting treatment with Danazol. The initial duration of treatment lasts from 3-6 months or 9 months, depending on the condition of the disease. After stopping the drug, the disease recurs, the patient may need to continue using another course of treatment.
In the prevention of hereditary angioedema: The usual dose is 200 mg administered 2 or 3 times daily. This dosage is not fixed but depends on the condition of each patient.
For the case of drug overdose, the patient may have symptoms or not experience symptoms, but still need to monitor their health status and need to notify the doctor.
In case of missed dose, the patient should take the medicine as soon as he remembers, however if it is almost time for the next dose, the patient should stop and skip the missed dose. Take the next dose as directed. Do not double the dose because there may be unwanted side effects.

3. Be careful when using Kupdina 100

Kupdina 100Mg can damage kidney and liver function. Therefore, when using the drug, patients should periodically monitor liver and kidney function. Because it has been reported that there have been cases of patients suffering from liver tumors when taking drugs for a long time. Use with caution in patients with hypercholesterolemia, as Danazol may reduce HDL, which leads to a decrease in cholesterol content in the vessel walls. Do not use this drug for pregnant women because it leads to side effects causing virilization of female fetuses. Women should use non-hormonal methods of contraception during treatment. Pregnant women should not use the drug. Use caution in children and adolescents because Kupdina 100 mg can cause precocious puberty in boys and virilization in girls. During treatment with Danazol, male patients need to check semen quality every 3-4 months, especially adolescents because the drug affects viscosity, volume, and total sperm count. and sperm motility. If abnormality occurs, the drug should be discontinued. For patients with cardiovascular disorders, kidney function, liver dysfunction, the drug should be used with caution because the drug makes the disease worse by causing fluid retention. Do not use the drug in patients with severe liver failure. Use with caution in patients with diabetes, dyslipidemia, epilepsy, erythrocytosis, migraine patients. Absolutely do not use the drug for patients with undiagnosed genital bleeding, patients with androgen-dependent cancer. Do not take the drug concurrently with 17α-alkyl derivatives because it may increase the risk of liver damage. If it is necessary to take these two drugs together, the patient should check the liver function during treatment. . Do not use the drug in patients with a history of thrombosis or thrombotic disorders. Use with caution in patients with porphyria.

4. Side effects

Virilization effect: Causes acne, edema, hirsutism, breast atrophy, voice change, increased oiliness of skin and hair, weight gain. In rare cases, testicular atrophy can occur. Common side effects caused by a decrease in estrogen levels in the body such as sweating, mental instability, vaginal inflammation with itching, dryness, with or without bleeding in women, nervousness, emotional instability is fine. Causes liver failure due to elevated liver enzymes, causing jaundice , cases have been reported in patients receiving doses of Danazol 400 mg or more daily. Allergic reactions with symptoms such as rash and nasal congestion. Central nervous system with manifestations such as sleep disturbance, headache, dizziness, fatigue or some other rare manifestations such as changes in appetite, mild paralysis of the limbs. Common gastro-intestinal side effects include gastroenteritis, vomiting, nausea, and constipation. Musculoskeletal, patients may experience muscle cramps or spasms, stiffness, joint swelling, back, neck or limb pain. Side effects related to the genitourinary tract such as blood in the urine. Cardiovascular and blood pressure: Patients may experience increased heart rate and increased blood pressure. Other reactions: Increased insulin requirements in patients with diabetes, alopecia, visual disturbances and benign intracranial hypertension, however this is rare.

5. Drug interactions

Drug interaction is a condition where the combined use of Kupdina 100mg with other drugs can cause harmful side effects or reduce the effectiveness of the drug. Therefore, patients should note that some of the following drugs will interact when used with Kupdina 100 mg:
Combine Kupdina 100mg with Insulin: Diabetics need to increase insulin dose to avoid side effects. wish can happen. Combining Kupdina 100mg with Tacrolimus: Danazol can inhibit metabolism leading to an increase in the concentration of the immunosuppressant tacrolimus. Concomitant use with Statins: Statin drugs in combination with Danazol can cause paroxysmal myoglobinuria. Carbamazepine: When co-administered with carbamazepine, Danazol will increase the half-life and decrease the body clearance of carbamazepine and increase the plasma concentration of carbamazepine. Concomitant use with Cyclosporin: Danazol inhibits metabolism leading to an increase in cyclosporin concentrations. Warfarin: Danazol may increase the effect of the anticoagulant warfarin. Effects on test results: Treatment with Kupdina 100 mg containing Danazol may affect the test results related to androstenedione, dehydroepiandrosterone, testosterone.

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