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Farico 60 belongs to the group of non-steroidal anti-inflammatory drugs with antipyretic, analgesic and anti-inflammatory effects. The drug is often prescribed in musculoskeletal diseases. So how does Farico 60 work and what should be noted when taking the drug?
1. What is Farico 60?
Farico 60 has the main ingredient is etoricoxib belonging to the group of non-steroidal anti-inflammatory drugs (NSAIDs) - selective COX-2 inhibitors.
Farico 60 acts through the mechanism of inhibiting prostaglandin synthesis, through inhibition of the enzyme cyclooxygenase-2 (COX-2), leading to a decrease in the formation of prostaglandins.
Etoricoxib component of Farico 60 does not inhibit cyclooxygenase-1 (COX-1) enzyme, so it will reduce the risk of side effects such as stomach ulcers, prolong bleeding time. However, it can cause renal side effects similar to other non-steroidal anti-inflammatory drugs.
Etoricoxib may increase the risk of vascular thrombosis in some patients because it inhibits prostaglandin synthesis.
After entering the body Farico 60 is bound to plasma proteins (92%), enters the cerebrospinal fluid, placenta and breast milk. The drug is completely eliminated in the urine.
2. Indications of the drug Farico 60
Farico 60 is indicated in the following medical conditions
Relief of mild to moderate acute and chronic pain symptoms. Treatment of pain in musculoskeletal diseases, ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, gout, .. Primary dysmenorrhea.
3. Contraindications of the drug Farico 60
Cases where Farico is not indicated 60
Allergy to Etoricoxib, Aspirin, NSAIDs or any other ingredient of the drug. Patients with a history of asthma, urticaria taking Farico 60 may be at increased risk of developing the disease. Are being treated for congestive heart failure, ischemic heart disease. Peripheral artery disease, cerebrovascular disease. Uncontrolled hypertension. Patients with active gastric - duodenal ulcer should not use Farico 60 . Chronic kidney disease, glomerular filtration rate < 30 mL/min. Patients with severe liver dysfunction. Children under 16 years old. Some notes when using Etoricoxib
Patients with a history of peptic ulcer, or gastrointestinal bleeding should be cautious when using the drug. Elderly patients, debilitated body easily cause gastrointestinal bleeding and impaired kidney function due to age. Patients with heart failure, liver failure, kidney failure when using Farico 60 may cause nephrotoxicity. Monitor the risk of cardiovascular complications when using the drug in patients with cardiovascular disease. Pregnant and lactating women should not use it because the safety of the drug in the placenta and breast milk has not been proven.
4. Farico 60 . drug interactions
Farico 60 may reduce the antihypertensive effect of angiotensin-converting enzyme inhibitors.
Furosemide and Thiazide are less effective when used with Farico 60 and increase the risk of kidney failure.
Concomitant use of Farico 60 and Aspirin may increase the incidence of peptic ulcers. Concomitant use of Farico 60 with Fluconazole may increase the concentration of the drug in the blood.
Bleeding complications, increased prothrombin time may occur in the elderly when using Farico 60 concurrently with Warfarin.
5. Dosage and usage
Osteoarthritis: 30mg/day. Maximum dose: 60 mg/day.
Rheumatoid arthritis, ankylosing spondylitis: Maximum dose 90 mg/day.
Moderate pain after dental surgery: Maximum dose: 90 mg once a day. Use continuously for 3 days.
Gout arthritis: Maximum dose: 120 mg/day.
Acute pain, primary dysmenorrhea: Maximum dose: 120 mg/day.
Patients with liver failure: Maximum dose: 60mg/day.
Patients with renal failure, glomerular filtration rate ≥ 30mL/min: no dose adjustment is required.
6. Side effects of Farico 60
Some unwanted effects may be encountered when using Farico 60:
Common
Digestive disorders, epigastric pain, diarrhea, nausea. Upper respiratory tract infections, pharyngitis, rhinitis. Sleep disturbance, headache, dizziness. Myocardial infarction, hypertension. Skin rash, itching. Uncommon
Gastric ulcer, pancreatitis, irritable bowel syndrome. Urinary tract infections . Anxiety, depression, hallucinations, decreased intelligence. Conjunctivitis, blurred vision. Increased heart rate, congestive heart failure. Blurred vision, conjunctivitis. Rare
Thrombophlebitis. Gastrointestinal ulcers cause bleeding. Hepatitis, gallstones. Thrombocytopenia, agranulocytosis, leukopenia. Reduce blood glucose. Acute renal failure. Anaphylactic reactions, Stevens-Johnson syndrome. In summary, Farico 60 is a drug with analgesic and anti-inflammatory effects indicated in musculoskeletal diseases. The drug works quickly, gives good effect and causes less stomach damage compared to other anti-inflammatory drugs. However, do not abuse and arbitrarily use the drug without a doctor's prescription.
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