Uses of Medicel 200

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1. What is Medicel 200?

Medicel 200 is a non-steroid pain reliever, antipyretic, anti-inflammatory product, used in the treatment of Gout and other musculoskeletal conditions. The main ingredient of Medicel 200 is the active ingredient Celecoxib 200mg. This product is manufactured by Zim Laboratories Ltd. circulating in Vietnam with registration number VN-21174-18. Besides the 200mg content, Medicel also has another strength form, Medicel 100.
Medicel 200 is prepared in the form of hard capsules for oral use, packing specifications for each box are 3 blisters x 10 tablets.

2. Pharmacology and mechanism of action Medicel 200

The active ingredient Celecoxib in Medicel belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), commonly prescribed in the treatment of osteoarthritis.
In terms of pharmacokinetics, Medicel 200 has the following characteristics:
Absorption: Medicel 200 is well absorbed from the gastrointestinal tract with relatively high bioavailability (about 90%); Distribution: After absorption, active ingredient Celecoxib is more than 85% bound to plasma proteins; Metabolism: Medicel is metabolized mainly in the liver; Elimination: This product is eliminated mainly in the urine as metabolites. The half-life is about 17 hours. Mechanism of action of Medicel 200: Prostaglandin is one of the important contributors in the mechanism of osteoarthritis, which in turn leads to swelling, heat, redness and pain in the joints. The main mechanism of action of Celecoxib in Medicel 200 is the blockade of Cyclooxygenase-2 (COX-2), an enzyme that makes prostaglandins, thereby reducing the concentration of prostaglandins in the blood. As a result, it helps joints reduce inflammation, reduce swelling, hot, red, and pain. The advantage of Celecoxib when compared with other NSAIDs is that it is less likely to cause peptic ulcers (at least for short-term treatment) and does not affect blood clotting.
Patients should note that each type of pharmaceutical product is manufactured with a primary effect in the treatment of a specific disease or condition. Medicel 200 is no exception, so patients should only use this product to treat the conditions specified in the drug instruction sheet. If using Medicel 200 to treat some other conditions not recommended by the manufacturer, the patient should only use it when prescribed by a doctor.

3. Indications and contraindications of Medicel 200

Medicel 200 is indicated for use mainly in the symptomatic treatment of osteoarthritis and rheumatoid arthritis in adults.
Cases of contraindications to Medicel 200:
Patients with a history of hypersensitivity to Celecoxib; Patients who are allergic to sulfonamide active ingredients; Patients with a history of bronchial asthma, urticaria or allergic reactions following the use of aspirin or other nonsteroidal anti-inflammatory drugs.

4. Instructions for using Medicel 200

Before starting to use, the patient should carefully read the instructions on how to use Medicel 200 listed in the drug instruction sheet, absolutely do not arbitrarily change the route of administration other than the information on the instruction sheet.
Recommended dosage of Medicel 200 : Specific dosage for each patient is different, but it is best to use the lowest effective dose to limit unwanted effects:
Treatment of symptoms in the following conditions: osteoarthritis: 1 Medicel 200 tablet taken 1 time per day or 1 Medicel 100 tablet x 2 times/day; Rheumatoid arthritis: 100-200mg/time, 2 times/day. Some notes about the dosage of Medicel 200:
The instructions on the dosage of Medicel 200 are mainly for adults taking orally. The specific dose depends on the doctor's prescription, the patient should not change it without permission; When using Medicel 200 for children, parents should note that this is a subject that is different from adults in terms of pharmacokinetics, pharmacodynamics or side effects. At the same time, children are not allowed to be included in clinical trials before the marketing authorization of new drugs, so special care should be taken when prescribing Medicel 200 for this population.

5. Some cautions when using Medicel 200

Before starting to use Medicel 200, patients should note the following issues:
People with a history of gastrointestinal ulcers, progressive kidney disease, edema, hypertension or heart failure, bronchial asthma, Pregnant women and nursing mothers or patients under 18 years of age need to be especially careful when using Medicel 200; Patients with moderate hepatic impairment require dose reduction and, if severe, should not take celecoxib-containing preparations such as Medicel 200; Care should be taken when combining Medicel 200 with ACE inhibitors, loop diuretics, thiazide diuretics, fluconazole antifungals or Warfarin anticoagulants; Patients being treated with lithium should be closely monitored when starting and ending treatment with Medicel 200. Medicel 200 when used during pregnancy has the risk of leading to some adverse effects (such as miscarriage, teratogenicity or fetal malformation...) in any stage, especially the third trimester. first month. Therefore, it is best not to use Medicel 200 for pregnant women. In the case of mandatory use, this subject should consult carefully with a doctor or pharmacist before making a decision.
Active ingredient Celecoxib in Medicel 200 can be passed to a baby through breastfeeding. Therefore, to ensure safety, breastfeeding mothers should not or limit the use of Medicel 200. At the same time, there are many other drugs that have not been fully identified during breast-feeding, so it is necessary to carefully consult the instructions for use and the opinion of your doctor or pharmacist before starting any use. which product.

6. Side effects of Medicel 200

Some common side effects of NSAIDs include:
Increased risk of gastrointestinal bleeding; Eating and drinking indigestion, diarrhea, epigastric pain, nausea; Peripheral edema; Headache, dizziness, insomnia; Rash; Sore throat. Gastrointestinal ulceration is theoretically possible with Medicel 200, however, short-term studies have shown a lower incidence of these events compared with other NSAIDs. At the same time, celecoxib also does not affect platelet function, so it does not cause coagulation disorders leading to an increased risk of bleeding like other NSAIDs.
Some of the most common adverse effects of Medicel 200:
Headache; Abdominal pain, indigestion, diarrhea, nausea, flatulence; Insomnia. Other less common side effects include:
Lightheadedness; Kidney failure, heart failure; Severe progressive hypertension; Chest pain; Tinnitus, deafness; Glare; Concerned; Sensitivity to light; Weight gain, water retention; Flu-like symptoms. Various forms of allergic reactions can occur with the use of any preparation, including Medicel 200 . People at high risk of developing an allergic reaction to this product include: a history of allergy to an active sulfonamide group (such as Bactrim), aspirin, or other NSAIDs.
It should be noted that the above is not a complete list of all the side effects of Medicel 200. In the process of use may occur other side effects that have not been published or studied, then patients should consult a doctor or pharmacist.

7. Drug interactions of Medicel 200

Concurrent use of two or more drugs often increases the risk of drug interactions and leads to antagonism or synergy. Therefore, it should be noted when using Medicel 200 with the following products:
Concurrent use of Medicel 200 with Aspirin or other NSAIDs (such as ibuprofen, naproxen...) may increase the risk of gastrointestinal ulcers; Concomitant administration of Medicel 200 with Fluconazole increases the concentration of celecoxib in the body by inhibiting the breakdown of celecoxib in the liver. Therefore, persons on antifungal therapy with fluconazole should start treatment with Medicel 200 at the lowest effective recommended dose; Celecoxib increases blood levels of lithium by 17%. Therefore, it is necessary to closely monitor lithium therapy during and after treatment with Medicel 200; People who use more than 3 drinks a day have a higher risk of stomach ulcers when taken with NSAIDs and the same is true for Medicel 200. Medicel 200 is a non-steroid pain reliever, antipyretic, anti-inflammatory, used in the treatment of Gout and other musculoskeletal conditions. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
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