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Mecam 15 is indicated for the treatment of pain and inflammation in bone and joint diseases such as osteoarthritis and rheumatoid arthritis... Let's learn about the uses and notes when using Mecam 15 through the article. down here.
1. Uses of Mecam
Mecam 15 is prepared in the form of round tablets, containing the active ingredient Meloxicam 15mg. Meloxicam is an oxicam derivative belonging to the group of non-steroidal anti-inflammatory drugs, with antipyretic, analgesic and anti-inflammatory effects. The mechanism of action of Meloxicam through inhibition of Cyclooxygenase (COX) reduces the synthesis of Prostaglandin - mediators that play an important role in the pathogenesis of fever, inflammation and pain. Meloxicam mainly inhibits on COX-2 (10 times more effective on COX-1), so side effects on the gastrointestinal tract are less than non-selective COX inhibitors.
Mecam 15 is indicated for the treatment of pain relief in bone and joint diseases such as osteoarthritis and rheumatoid arthritis ...
2. Dosage of Mecam 15
Mecam 15 is an anti-inflammatory pain reliever, with a dose prescribed by a doctor based on the patient's condition and tolerability. To reduce the risk of gastrointestinal side effects, the lowest effective dose should be used for the shortest period of time. Some recommendations on the dosage of Mecam are as follows:
Adults:
Osteoarthritis, rheumatoid arthritis: The starting dose is 7.5mg/day, not exceeding 15mg/day. In case of long-term use of the drug, especially in the elderly who are not at risk of adverse events, the recommended dose is 7.5mg/time/day. Exacerbation of osteoarthritis: The recommended dose is 7.5mg/time/day, when necessary it can be increased to 15mg/time/day. Elderly people: The recommended dose of Mecam 15 is 7.5mg/time/day, when needed or symptoms do not improve can be increased to 15mg/time/day.
Patients with hepatic and renal impairment: No dose adjustment is required in patients with mild to moderate hepatic or renal impairment. For patients with liver failure, severe kidney failure, it is recommended not to use the drug.
3. Side effects of Mecam 15
Mecam 15 may cause some unwanted effects as follows:
Common: Nausea, digestive disorders, constipation, abdominal pain, flatulence, anemia, diarrhea, itchy skin, rash , headache and edema. Uncommon: Flatulence, mild elevation of serum transaminases and bilirubin, peptic ulcer, esophagitis, potential gastrointestinal bleeding, thrombocytopenia, leukopenia, hypertension, palpitations, thrombotic risk cardiovascular disease, increased blood urea and creatinine, tinnitus, dizziness and somnolence. Rare: Gastric ulcer-perforation, colitis, gastritis, hepatitis, erythema multiforme, increased photosensitivity, Lyell's syndrome and bronchial asthma. Patients need to stop using Mecam 15 and notify the treating doctor when experiencing unwanted effects.
4. Note when using Mecam 15
4.1. Contraindications Contraindicated to use Mecam 15 in the following cases:
Hypersensitivity to Meloxicam or any component of Mecam 15; Hypersensitivity to Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs); Patients with bronchial asthma, nasal polyps, urticaria and vasomotor edema... when treated with non-steroidal anti-inflammatory drugs; Patients with peptic ulcer disease or active enteritis; Patients with liver failure, severe renal failure not on dialysis; Patients with uncontrolled heart failure; Children and adolescents over 18 years old; Pregnant women; Women who are breastfeeding; Patients with recent cerebrovascular bleeding or diagnosed with a systemic bleeding disorder; The patient is being treated with a CYP2C9 inhibitor. 4.2. Cardiovascular effects: Meloxicam in particular, and nonsteroidal anti-inflammatory drugs in general, may increase the risk of cardiovascular events, including stroke and myocardial infarction. . This risk appears as early as the first few weeks of treatment with Mecam and may increase with duration of treatment. Therefore, patients should inform their physician of any history and symptoms of a serious cardiovascular event. To reduce the risk of cardiovascular events, patients need to take the lowest effective dose for the shortest time.
Effects on the stomach - intestines: Mecam 15 can cause adverse gastrointestinal events such as bleeding, inflammation, ulceration and perforation of the stomach, small intestine or large intestine, even leading to death. death. Therefore, caution should be exercised when using NSAIDs in patients with a history of ulcers or gastrointestinal bleeding in the gastrointestinal tract.
Effects on the liver: Meloxicam in particular and NSAIDs in general can increase liver enzymes, rare cases of serious liver reactions occur. In case the patient develops symptoms similar to the development of liver disease or if systemic manifestations occur, Meloxicam should be discontinued.
Hypertension: Mecam 15 may lead to the onset of a new hypertensive crisis or worsen existing hypertension, which increases cardiovascular events. Therefore, the drug should be used with caution in patients with hypertension.
Patients with edema, congestive heart failure: Edema and fluid retention have been reported in some patients treated with NSAIDs, so caution should be taken when using Meloxicam in patients with fluid retention conditions such as edema and congestive heart failure.
Effects on the kidneys: Long-term treatment with Mecam 15 can cause damage and decline in kidney function.
Anaphylactic reactions : May occur in patients not previously treated with Meloxicam. In patients with aspirin-sensitive asthma attacks, long-term aspirin therapy is associated with bronchospasm and possibly death, because of cross-reactivity between aspirin and NSAIDs. Therefore, Meloxicam should not be used in patients sensitive to Aspirin.
Adverse reactions on skin and mucous membranes: NSAIDs in general and Meloxicam in particular can cause adverse reactions on skin and mucous membranes such as Stevens-Johnsons syndrome, exfoliative dermatitis, toxic epidermal necrolysis. and can be deadly. Patients should be informed about the signs and symptoms of adverse reactions on the skin and mucous membranes and should stop using the drug as soon as a reaction occurs.
Patients being treated with Corticosteroids: Do not use Mecam with Corticosteroids at the same time because it increases the risk of unwanted effects, especially on the gastrointestinal tract.
Concealing symptoms of inflammation and fever: Meloxicam has the effect of reducing inflammation and reducing fever, so it can hide diagnostic signs, detect complications of pathology, and pain.
Effects on blood: Mecam 15 may cause anemia in some patients. Patients on long-term treatment with Meloxicam should check their red blood cell volume and hemoglobin when they have any symptoms or signs of anemia.
For pregnant women: Mecam should not be used in pregnant women due to the risk of premature closure of the ductus arteriosus or other potential risk to the fetus.
For lactating women: Meloxicam crosses the breast milk barrier and may harm a nursing infant. Therefore, Mecam should not be used in women who are breast-feeding.
5. Drug interactions
Mecam 15 may cause some interactions as follows:
The risk of adverse events, especially on the gastrointestinal tract, is increased when Mecam is used concomitantly with Aspirin and other NSAIDs. Co-administration of Mecam with anticoagulants such as Heparin, Ticlodipine, thrombolytics may increase the risk of bleeding. Interactions occur when Meloxicam is used with Lithium, a drug to treat mood disorders. Serotonin reuptake inhibitors for depression. Rheumatoid arthritis medicine; Methotrexate drug ; Meloxicam reduces the therapeutic effect of antihypertensive drugs such as ACE inhibitors, beta-channel blockers, diuretics and vasodilators.... Drug interactions occur to reduce the therapeutic effect of Mecam. 15, increased risk of unwanted effects. Therefore, patients need to inform the treating doctor about the drugs they are using, including food supplements, before treatment with Mecam 15 to ensure safety and effectiveness.
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