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Atorvastatin is a medication that lowers LDL cholesterol in the blood. Unlike other drugs in the statin class, the active ingredient Atorvastatin can also lower triglyceride levels. This active ingredient is present in the drug Lipitusar.1. What is Lipitusar?
The active ingredient Lipitusar is Atorvastatin (as Atorvastatin calcium trihydrate) 10mg. This is a product of the branch of Phong Phu Pharmaceutical Joint Stock Company - Usarichpharm Pharmaceutical Factory - VIETNAM in the form of film-coated tablets. The drug is circulated in Vietnam with registration number VD-26643-17.Atorvastatin is an active ingredient that lowers cholesterol. This active ingredient inhibits cholesterol production in the liver by inhibiting a cholesterol-producing enzyme, HMG CoA reductase. Thereby reducing levels of total cholesterol, LDL cholesterol (the "bad" cholesterol that causes coronary heart disease). Lowering LDL cholesterol levels slows the progression and may even reverse coronary heart disease.
Unlike other drugs in the statin class, the active ingredient Atorvastatin can reduce blood triglyceride levels, high blood triglyceride levels are also associated with coronary heart disease.
2. What are the uses of Lipitusar?
Atorvastatin is indicated for use to reduce total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides, and otherwise increase HDL-cholesterol in patients with primary hypercholesterolemia. Indications for the use of Lipitusar in patients with beta-lipoproteinemia unresponsive to diet. Indicated for the reduction of total cholesterol and LDL-cholesterol in patients with homozygous familial hypercholesterolemia and inadequate dietary intake.3. Contraindications to the use of Lipitusar
Patients with hypersensitivity to drugs of the HMG-CoA reductase inhibitor group Patients with active liver disease or unexplained persistent elevations in serum transaminases Pregnant women Lactating mothers.
4. Dosage - How to take Lipitusar
Lipitusar can be taken at any time of the day, regardless of meals, with the recommended dose of Lipitusar as follows:
Hypercholesterolemia (heterozygous familial & non-familial), Mixed dyslipidemia: The recommended starting dose of Lipitusar is 10-20mg, once a day. Patients with a significant need to reduce LDL cholesterol (more than 45% reduction) can start Lipitusar at a dose of 40mg, once a day. The therapeutic dose range of Lipitusar is 10 - 80mg, once daily. After starting treatment and/or after increasing the dose of Lipitusar, it is necessary to assess the blood lipids within 2-4 weeks to adjust the dose of Lipitusar accordingly. Homozygous familial hypercholesterolemia: 10 - 80 mg/day should be combined with Lipitusar with other lipid-lowering measures. Combination therapy: Atorvastatin contained in Lipitusar can be used in combination with Resin to increase the effectiveness of treatment. Dosage of Lipitusar in patients with renal failure: No dose adjustment of Lipitusar is required.
5. Drug interactions of the drug Lipitusar
Anticoagulants, indandione in combination with Lipitusar drugs will increase bleeding time or prothrombin time. Prothrombin time should be monitored in patients receiving combination of Lipitusar and anticoagulants; Cyclosporine, erythromycin, gemfibrozil, immunosuppressants, niacin: combined use increases the risk of myopathy. Digoxin: used in combination with Lipitusar drug causes a slight increase in serum digoxin concentration
6. Side effects of Lipitusar
Lipitusar is well tolerated, side effects are usually mild and transient. Possible side effects when taking Lipitusar medicine such as constipation, flatulence, indigestion, abdominal pain, nausea, vomiting, headache, dizziness.
7. Precautions when using Lipitusar
Before treatment with Lipitusar drug, it is necessary to pay attention to exclude the causes of secondary dyslipidemia, to measure lipid indices and to conduct periodic quantification, at intervals of not less than 4 weeks/time. During treatment with HMG-CoA reductase inhibitors such as Lipitusar, if the patient's creatine kinase is elevated, myositis develops, or the serum liver enzyme level rises to 3 times the upper limit of normal, the dose should be reduced. Lipitusar drug or stop treatment. Use Lipitusar with caution in patients with liver dysfunction, heavy drinkers. Patients need a reasonable diet before treatment with Lipitusar, should maintain this diet throughout the course of treatment. Avoid use of Lipitusar in pregnant women because of reported congenital malformations, in addition to the reduction of cholesterol synthesis may affect the development of the fetus. Note during lactation: Lipitusar drug can be passed to the baby through breastfeeding, so it is best not to or limit the use of Lipitusar during breastfeeding. Before using the drug during this period, the mother should carefully read the instructions for use and it is best to consult a doctor, pharmacist before deciding to use the drug.
