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Lezovar drug has the main active ingredient Lansoprazole 15mg and other excipients in sufficient quantity. The dosage form of the drug is capsule, suitable for direct oral administration. Lezovar belongs to the group of drugs for the treatment of diseases of the gastrointestinal tract such as acute peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome.
1. What is Lezovar?
What is Lezovar? Lezovar drug has the main active ingredient is Lansoprazole 15mg and other excipients in sufficient quantity. The dosage form of the drug is capsules, suitable for direct oral use. Packing is a box of 3 blisters or a box of 10 blisters and each blister contains 10 hard capsules. The drug can also be packaged as a box of 14 capsules. Lezovar belongs to the group of drugs used to treat diseases of the gastrointestinal tract such as acute peptic ulcer, ulcerative esophagitis and Zollinger-Ellison syndrome.
1.1. Pharmacodynamics of the active ingredient Lansoprazole Main active ingredient Lansoprazole is a potent inhibitor of acid secretion caused by inhibiting the enzyme H+,K+ ATPase activity in parietal cells of the gastric mucosa and plays an important role as a proton pump. Clinically, the main active ingredient Lansoprazole achieves a fast and high healing rate in the treatment of gastric ulcer and duodenal ulcer. In addition, this drug has also been shown to be effective in the treatment of reflux esophagitis and Zollinger-Ellison syndrome.
1.2. Pharmacokinetics of the active ingredient Lansoprazole Absorption: Lansoprazole is rapidly absorbed from the gastrointestinal tract, but varies depending on dose and gastric pH. Oral bioavailability can be as high as 70% with repeated use. Distribution: The drug is strongly bound to plasma proteins. Metabolism: The drug is metabolized mainly by the liver. Elimination ability: Active ingredient Lansoprazole is eliminated by the kidneys 80%, the mean half-life is 30 to 90 minutes. 1.3. The effect of the active ingredient Lansoprazole Active ingredient Lansoprazole inhibits H + / K + - ATPase. The drug causes specific and irreversible inhibition of the proton pump due to its selective effect on gastric parietal cells, so it acts faster and more effectively than other drugs. The rate of scar or ulcer healing can reach 95% after 8 weeks of treatment.
The drug has little effect on gastric juice volume, pepsin secretion, gastric endogenous factor and gastric contractility.
2. What disease does Lezovar treat?
What are the uses of Lezovar? This is a drug that works in the treatment of specific diseases as follows:Treatment of esophagitis accompanied by ulcers in people with gastroesophageal reflux disease. Treatment of pathologically specific hypersecretory conditions such as polyendocrine tumors, systemic mastocytosis, and Zollinger-Ellison syndrome. Treatment of acute gastric and duodenal ulcers caused by infection with or without infection with H.pylori bacteria, also known as HP bacteria. Treatment of peptic ulcers caused by the use of non-steroidal anti-inflammatory drugs, also known as NSAIDs.
3. Usage and dosage of the drug Lezovar
3.1. How to use Lezovar Lezovar drug is prepared in the form of hard capsules containing Lansoprazole microparticles coated in the intestine, suitable for direct oral use. Users should take Lezovar pills in the morning before eating, do not break or chew tablets when using. 3.2. Dosage of the drug Lezovar Dosage to treat peptic ulcers is to use 1 tablet / day for an average of 4 to 8 weeks. Dosage for treatment of erosive esophagitis caused by gastroesophageal reflux with adults use 1 tablet / day, for a period of 4 to 8 weeks and can be treated for another 8 weeks if not cured. Dosage for treatment of gastric ulcers while taking non-steroidal anti-inflammatory drugs is 1 tablet/day, taken for 8 weeks. Dosage for treatment of pathological acidosis is 60 mg (equivalent to 2 tablets), orally once a day, then adjust the dose according to tolerance and continue treatment until clinical results are achieved. Dosage from 1 to 6 tablets / day (divided into 1 to 2 oral doses) For people with severe liver failure, it is necessary to reduce the therapeutic dose. The maximum dose is 30 mg/day equivalent to 2 pills/day. It should be noted: The dose of Lezovar above is for reference only, patients need to use the drug exactly as directed by the doctor or pharmacist who has prescribed it. Absolutely do not use Lezovar in higher doses for the purpose of quick recovery.
4. Undesirable effects of the drug Lezovar
During the use of Lezovar, users of the drug may experience some unwanted reactions to the body, including:
For the liver: It is caused by an increase in SGOT, SGPT, Phosphatase index. -Alkali, LDH or G-GTP occurs infrequently, so close monitoring is required. If abnormal signs appear, the use of Lezovar should be discontinued. For the digestive system: Occasionally there may be digestive disorders, constipation, diarrhea, bloating or dry mouth. For blood: Anemia, decreased white blood cell count, or increased eosinophil count may occur infrequently, thrombocytopenia rarely occurs. Nervous system: Headache, drowsiness may occur infrequently; Insomnia and dizziness are rare. Hypersensitivity reactions: Rash and itching of the skin may occasionally occur. In this case, the user should stop using the medicine containing the active ingredient, Lansoprazole. Other undesirable effects such as fever or increased total cholesterol and uric acid may also occur.
5. Lezovar drug interactions
Lansoprazole is metabolized by the cytochrome P450 enzyme system, so it interacts with other drugs that are metabolised by this same enzyme system. Therefore, lansoprazole should not be used with other drugs that are metabolized by the cytochrome P450 system. No clinically important effects on the concentrations of diazepam, phenytoin, theophylline, prednisolone or warfarin were observed when co-administered with Lezovar. The main active ingredient Lansoprazole reduces the effect of the active ingredient Ketoconazole, itraconazole and other drugs whose absorption requires an acidic environment. Sucralfate slows and reduces the absorption of active ingredient Lansoprazole (approximately 30%). In order to avoid drug interactions, patients need to inform their doctors about the drugs, herbs, and dietary supplements being used so that the doctor can consider and make appropriate adjustments. ensure effective treatment, while avoiding unwanted side effects.6. Some notes when using Lezovar
6.1. Contraindications of the drug Lezovar Contraindications of the drug Lezovar in the following cases:
People who are sensitive or sensitive to the components of the drug Lezovar. Patients with malignant peptic ulcer disease. Use caution when using Lezovar for pregnant and lactating women. 6.2. Notes and precautions of the drug Lezovar Use caution when using Lezovar for children, pregnant women, lactating women, people with liver failure. During treatment, the treating doctor will assign careful monitoring of the disease status for each specific person. Lezovar should not be used in maintenance therapy if there is insufficient experience with long-term use. Medicines containing the active ingredient Lansoprazole should be used with caution in people with a history of drug sensitivity, liver dysfunction, and the elderly. Use in children: The safety of Lansoprazole in children has not been established (clinical trials are limited). Use in the elderly: Because the secretion of gastric acid and other physiological functions has decreased in the elderly, so Lezovar should be used with caution. Use in pregnancy and lactation: When experiments were performed on rats, the concentration of lansoprazole in the embryonic serum was higher than in the maternal rat. For rabbits (30mg/kg oral dose) increased embryonic mortality. Therefore, Lezovar should not be used in pregnant women and suspected pregnant women, unless it is really helpful. Currently, there have been reports in animal studies that the active ingredient Lansoprazole is likely to be excreted in human milk. Therefore, the use of Lezovar in the mother should be avoided during lactation. The patient should only use the drug in cases where it is absolutely necessary after the treating doctor has weighed the benefits and possible risks to the health of the baby. At the same time, the mother also needs to stop using breastfeeding. Store Lezovar in a dry place, away from direct light. Besides, it is necessary to keep Lezovar medicine out of the reach of children and family pets. Absolutely do not use Lezovar medicine after the expiry date.
In summary, Lezovar drug has the main active ingredient Lansoprazole 15mg and other excipients in a sufficient amount. Lezovar belongs to the group of drugs for the treatment of diseases of the gastrointestinal tract, esophagitis with ulceration, acute peptic ulcer, Zollinger-Ellison syndrome. When prescribed for use, patients should carefully read the instructions for use, consult a doctor / pharmacist before using the drug. Absolutely do not arbitrarily buy Lezovar to treat diseases at home, because there may be unwanted side effects to health.
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