Uses of Levosulpiride

This is an automatically translated article.

1. What is Levosulpiride?

Levosulpiride belongs to the group of psychotropic drugs, with the main active ingredient being Levosulpiride. The drug is prepared in the form of tablets, each containing 50mg Levosulpiride or 25mg Levosulpiride and other excipients. Currently, the drug has 2 packaging forms:
Levosulpiride 50mg: box of 10 blisters x 10 tablets or box of 3 blisters x 10 tablets Levosulpiride 25mg: box of 3 blisters, each blister has 10 tablets

2. Uses of Levosulpiride

Levosulpiride (25mg and 50mg) is commonly indicated in the treatment of acute and chronic schizophrenia in adults and children over 14 years of age. In addition, Levosulpiride 50mg is also used to treat symptoms of functional gastrointestinal disorders such as: epigastric discomfort, abdominal distension, belching, nausea and vomiting, heartburn, ...
But However, absolutely do not use Levosulpiride for the following subjects:
Allergic to the components of Levosulpiride Increase the possibility of drug intolerance Under 14 years old Women who are pregnant or suspected of being pregnant Intestinal disturbances, Gastrointestinal bleeding, mechanical intestinal obstruction, intestinal perforation Adrenal myeloma Breast cancer, acute breast disease Epilepsy, mania, manic-depressive psychosis.

3. Dosage and how to take Levosulpiride

Patients should always carefully read the information about the drug in the attached instruction sheet, absolutely follow the instructions of the doctor or pharmacist about the dosage and route of administration. You must not increase the dose, reduce the dose or give Levosulpiride to other people when you see that they have the same symptoms as you.
Dosage:
Treatment of functional digestive symptoms: 25mg/time x 3 times/day Treatment of schizophrenia: 200-300mg/day, divided into 3 oral doses. Dose reduction is required in children over 14 years of age. For patients with renal impairment, the dose should be reduced or the interval between doses increased depending on creatinine clearance. Patients with moderate to severe renal impairment should not take Levosulpiride if other treatments are available.
Cases of overdose occurred when taking the drug with a dose of 1 - 16g, but no death was recorded at the dose of 16g. With different doses will have different clinical manifestations. At dose 1-3g: gloomy consciousness, restlessness, extrapyramidal symptoms. Doses of 3-7g cause agitation, confusion, extrapyramidal syndrome. Doses > 7g met more coma, hypotension. These symptoms disappear within a few hours, and the coma alone can last up to 4 days. There is currently no specific antidote for Levosulpiride. Therefore, it is necessary to rinse the stomach, drink activated charcoal, and alkalinize the urine to increase drug elimination. In case of necessity, Parkinson's drugs can be used and supportive and symptomatic treatment can be used.
In case of missed dose, take another dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as directed. Do not make up for a missed dose by taking a double dose.

4. Levosulpiride side effects

During treatment with Levosulpiride, you may experience the following undesirable effects:
Common: drowsiness, insomnia, hyperprolactinemia, menstrual disorders, amenorrhea, increased lactation. Uncommon: excitability, extrapyramidal syndrome with symptoms of torticollis, eye rotation, restlessness, Parkinson's syndrome, arrhythmia, torsades de pointes. Rare: gynecomastia, dyskinesia, malignant sedation-induced high fever, hypotension, arrhythmia, bradycardia, hypothermia, cholestatic jaundice, ... In addition, you have may experience undesirable effects not listed above. Talk to your doctor or pharmacist about any side effects you may have.

5. Drug interactions

The phenomenon of drug interactions can change the effect or increase the toxicity of the drug. Make a list of all the medicines you are taking for your doctor or pharmacist. Do not arbitrarily stop the drug, increase or decrease the dose without the permission of the doctor, especially:
Sucralfate and aluminum-containing antacids reduce the absorption of Levosulpiride. Therefore, levosulpiride should be taken 2 hours after antacids. Lithium enhances the extrapyramidal potential of Levosulpiride by increasing Levosulpiride's ability to bind to dopaminergic D2 receptors in the brain. Do not combine L-dopa with Levosulpiride. Alcohol enhances the sedative effect of Levosulpiride. Therefore, you need to abstain from alcohol and drinks that are still in the process of taking the drug. Antihypertensive drugs increase the antihypertensive effect and cause hypotension when combined. Central nervous system depressants: Increased CNS depressant effects may cause adverse effects, especially for drivers and machine operators.

6. Some notes when using Levosulpiride

Pregnant women: Levosulpiride can cross the placenta and cause unwanted effects on the nervous system of the fetus. Therefore, do not take Levosulpiride during pregnancy. Lactation: Levosulpiride is found in relatively high concentrations in breast milk and may affect the infant. Therefore, do not take Levosulpiride while breastfeeding. Levosulpiride should be used with caution in the following subjects: patients with renal failure, the elderly, alcohol drinkers, unexplained high fever, hypomania.

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