Uses of letarid

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1. Uses of Letarid

“What does Letarid do? ". The drug Letarid contains the active ingredient Levosulpirid in the form of tablets and is indicated in the treatment of the following conditions:
Reactive depression and endogenous depression; Patients with mental disorders; Patients with acute and chronic schizophrenia.

2. Dosage of Letarid

Letarid belongs to the group of prescription drugs, the dose and duration of treatment are prescribed by the treating doctor. Patients need to use the drug dose as prescribed, do not overdose Letarid drug or prolong the treatment time. Some recommendations on the dosage of Letarid are as follows:
Adults: Treatment of acute psychotic disorders use a dose of 100mg/time x 2-3 times/day. The maintenance dose of Letarid is 50mg/time x 3 times/day; Adolescents and children: There are currently no studies proving the effects of Letarid in adolescents and children, so it should not be used in the treatment of these subjects; Renal Impairment: The dose of Letarid should be reduced in patients with renal impairment depending on creatinine clearance. For patients with creatinine clearance of 30-60ml/min, the dose is 2/3 of the normal dose. For patients with creatinine clearance from 10-30ml/min, the dose is equal to 1/2 of the normal human dose. For patients with clearance less than 10ml/min, the dose is 1/3 of the normal person. The drug is taken orally, the patient should take the drug with a sufficient amount of water before meals. The dosing time should be fixed at one hour per day.

3. Side effects of Letarid

Letarid drug may cause some side effects as follows:
Rare: Heart rhythm disturbances such as ventricular tachycardia, torsades de pointes, cardiac arrest, ventricular fibrillation...; Very rare: Neurological disorders, psychomotor disorders, extrapyramidal syndromes such as Parkinson's, tremor, dystonia, allergic reactions...; Frequency unknown: Hormonal disorders such as gynecomastia, amenorrhea, hyperprolactinemia, altered libido; weight gain with prolonged use of the drug; occurrence of venous thrombosis, discontinuation syndrome in neonates; extrapyramidal syndrome.

4. Notes when using Letarid

4.1. Contraindications Contraindicated to use Letarid drug in the following cases:
Patients are allergic to Levosulpirid or to any ingredient of Letarid drug; Use with caution in patients with manic, epileptic or manic episodes in bipolar disorder; Use caution when using the drug in hypertensive patients with suspected adrenal myeloma, patients with signs of heart failure (these cases are not absolute contraindications); Studies have demonstrated a correlation between hyperprolactinemia in most patients treated with psychotropic drugs. Therefore, the use of Letarid is contraindicated in carriers of malignancy; Pregnant women, lactating women. 4.2. Precautions for use Studies have shown that patients treated with atypical antipsychotics have a 3-fold increased risk of cerebrovascular accident. Therefore, caution should be exercised when using Letarid in patients with predisposing factors for stroke. A potentially fatal neuroleptic malignant syndrome has been reported with neuroleptic therapy. Symptoms may include muscle stiffness, high fever, vegetative disorders (sweating, unstable blood pressure, arrhythmia), loss of movement, altered cognitive status that can lead to coma. .. In case the above symptoms appear, the patient should stop using the drug and notify the treating doctor for treatment. It is not recommended to use the drug when the patient is suffering from a condition that stimulates gastrointestinal motility, because it can cause intestinal obstruction, gastrointestinal bleeding, intestinal perforation. Levosulpiride should be used with caution in patients with cardiovascular disease or a family history of QT prolongation. An increased risk of venous thromboembolism has been reported with antipsychotic therapy, so the risk factors for venous thrombosis should be determined before and during treatment. antipsychotic for preventive measures. It is not recommended to use alcohol during treatment with Levosulpiride. Letarid contains the excipient Lactose Monhydrate, so the drug should not be used in patients with impaired lactase enzyme activity, in people with Glucose - Galactose intolerance. For drivers, operating machinery: Letarid drug can cause dizziness, movement disorders... Therefore, caution should be exercised when using the drug in drivers, operating machinery.

5. Drug interactions

Use of Letarid together with drugs that prolong the QT interval may increase the risk of cardiac arrhythmias. Antacids and sucralfate reduce the absorption of Levosulpiride. Therefore, do not use drugs at the same time, in case of necessity, take them at least 2 hours apart. Lithium increases the risk of extrapyramidal disorders of Letarid by increasing the drug's ability to bind to dopamine D2 receptors in the brain. Levodopa is competitive with Levosulpiride, so the concomitant use of these two drugs is contraindicated. Alcohol increases the risk of sedation of the drug, so it is contraindicated for patients to drink alcohol during treatment with Letarid. Interaction with antihypertensive drugs: Letarid increases the risk of hypotensive effects, orthostatic hypotension. Therefore, care should be taken when using these drugs in combination. Interactions with CNS depressants: Increased risk of sedation when used in combination with Letarid. Drug interactions occur to reduce the therapeutic effect of Letarid, increase the risk of unwanted effects. Therefore, patients need to inform the treating doctor of all medicines they are using (over-the-counter drugs, prescription drugs) and functional foods before being treated with Letarid to ensure safety and effectiveness. during treatment. Letarid drug contains active ingredient Levosulporid 50mg is indicated in the treatment of depression, psychosis, acute and chronic psychosis. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
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