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Kuptapazol medicine is made in the form of tablets with the main ingredient in each tablet is Methimazol 5mg. So what is Kuptapazol drug, what is the effect of the drug and how to use it, let's find out through the article below.1. What is Kuptapazol?
The main ingredient of Kuptapazol is Methimazol, which is an inhibitor of thyroid hormone synthesis, effective in the treatment of hyperthyroidism.Kuptapazol does not affect the potency of thyroxine and triiodothyronin that is retained in the thyroid gland or circulates in the blood or interferes with the potency of thyroid hormones.
Kuptapazol is indicated in the following cases:
Treatment of hyperthyroidism. Improve hyperthyroidism to prepare for surgery to remove part of the thyroid gland or use radioactive iodine. The drug is contraindicated in the following cases:
People with hypersensitivity to any ingredient of Kuptapazol. Cases of agranulocytosis, agranulocytosis, diffuse goiter in the chest, acromegaly, marrow failure or liver failure. Notes and precautions when using Kuptapazol:
Patients using Kuptapazol should be closely monitored and cautious. Report any signs of fatigue immediately to your doctor, especially symptoms of sore throat, fever, skin rash, headache, or general malaise. In such cases, a white blood cell count should be checked to determine if agranulocytosis has progressed. Keep Kuptapazol out of reach of children. Use Kuptapazol drug for pregnant women: Because the active ingredient Methimazol in Kuptapazol crosses the placenta and can harm the fetus, the drug can cause goiter, hypothyroidism in the developing fetus. However, Kuptapazol can still be used wisely in the treatment of hyperthyroidism during pregnancy. If Kuptapazol is used during pregnancy to treat hyperthyroidism, the dose should be carefully adjusted, a dose of Kuptapazol should be adequate but not excessive, this is necessary and thyroid hormone should be used concurrently. time to prevent hypothyroidism in the mother and possibly the fetus. Use of Kuptapazol and thyroid hormone should be continued throughout pregnancy and after delivery. However, thyroid dysfunction decreases in many women during pregnancy, so the dose of Kuptapazol can be reduced and, in some patients, discontinued 2 or 3 weeks before delivery. If Kuptapazol is used during pregnancy or if you become pregnant while taking it, your doctor should inform the patient of the potential hazard to the unborn baby. Use of Kuptapazol in lactating women: The active ingredient Methimazol in Kuptapazol is distributed into breast milk. Because of the potential for serious adverse effects of methimazol in a nursing infant, a decision should be made whether to discontinue nursing or discontinue Kuptapazol, taking into account the importance of the drug to the mother. Kuptapazol may cause dizziness and drowsiness. Therefore, caution should be exercised when driving or operating machinery while using Kuptapazol.
2. Dosage and how to use Kuptapazol
Kuptapazol drug is used orally, usually the drug is divided into 3 times a day, the times are about 8 hours apart.The dose of Kuptapazol should be according to the instructions of the specialist, the reference dose is as follows:
Adults: Use a starting dose of 15mg/day for mild hyperthyroidism, use a dose of 30-40mg / day for moderately severe cases and use a dose of 60mg / day for severe cases. Divide the above dose into 3 doses taken about 8 hours apart. The maintenance dose is 5-15mg/day. Children: The starting dose is 0.4mg/kg body weight/day, divided into 3 oral doses 8 hours apart. The maintenance dose is about 1/2 of the starting dose. Symptoms of Kuptapazol overdose include nausea, vomiting, epigastric pain, fever, headache, joint pain, itching, and edema. Aplastic anemia (pancytopenia) or agranulocytosis can occur for hours to days. Infrequent cases are hepatitis, dermatitis, exfoliative dermatitis, symptoms of kidney failure, neuropathy, CNS excitability or depression. Although not well studied, methimazole causes agranulocytosis commonly associated with the use of doses of 40 mg/day or more in patients over 40 years of age.
If an overdose of Kuptapazol occurs, the patient should receive symptomatic and supportive treatment.
3. Kuptapazol side effects
The main undesirable effects of Kuptapazol include:Inhibition of bone marrow's hematopoietic ability, causing agranulocytosis, agranulocytosis and thrombocytopenia. Aplastic anemia. Drug fever. Lupus-like syndrome. Insulin autoimmune syndrome can lead to hypoglycemic coma. Hepatitis, jaundice symptoms may persist for weeks after stopping the drug. Inflammation around the arteries. Decreased blood prothrombin. Nephritis occurs very rarely. The minor adverse effects of Kuptapazol include:
Skin rash. You are jute. Nausea, vomiting. Epigastric pain . Athritis. Sensation. Loss of taste. Unusual hair loss. Muscle pain. Headache . Itchy. Chicken sleep. Neuritis. Fu Dizzy. Skin pigmentation. Jaundice. Salivary gland disease. Lymph node disease. It should be noted that approximately 10% of patients with untreated hyperthyroidism still have leukopenia (white blood cell count less than 4000/mm3) often accompanied by agranulocytosis.
If you notice any unusual symptoms when using Kuptapazol, you should immediately notify your doctor or go to a medical facility for timely treatment.
4. Interaction of Kuptapazol with other drugs
Concomitant use of Kuptapazol with anticoagulants (oral) may interfere with anticoagulant effects due to vitamin K antagonistic effects. Hyperthyroidism may increase the rate of metabolism and elimination of blockers. beta. It is necessary to reduce the dose of beta-adrenergic blocker when the patient with hyperthyroidism is treated with Kuptapazol and gets better. Serum digitalis concentrations may be increased when patients with hyperthyroidism receive stable digitalis glycosides, reducing digitalis dose when co-administered with Kuptapazol. Above is the information related to the drug Kuptapazol. If you have any questions about the medicine, contact your doctor or pharmacist immediately.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
