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Indomethacin is a prescription drug, used for anti-inflammatory, pain relief, especially musculoskeletal. Before using Indomethacin you should consult your doctor. Here is some information to help you understand what Indomethacin is.
1. Uses of Indomethacin
Indometacin has anti-inflammatory effects and is listed as a non-steroidal anti-inflammatory drug. Indometacin is a derivative of indolacetic acid. Therefore, Indomethacin is used in antipyretic, analgesic, anti-inflammatory, and inhibits platelet aggregation.
The principle of action of the drug Indomethacin is still being studied and analyzed. The presently documented findings suggest that it is believed that indometacin exerts its action on the basis of its ability to inhibit Prostaglandin synthetase. The same inhibition that reduces production can affect several other enzymes. At the same time, this inhibition will reduce the ability to platelet aggregation and the effect lasts for 24 hours of you using the drug. Over this time, the concentration of the drug in the blood will decrease until it returns to normal.
Indometacin has the ability to inhibit the ability of the blood supply to the kidneys. Therefore, you need to carefully refer to the indications for use before taking the drug:
Treatment of rheumatoid arthritis; Treatment of moderate to severe osteoarthritis; Treatment of ankylosing spondylitis; Treatment of tendonitis or tendon sheath; Treatment of rheumatoid arthritis. The above indications are for reference only and may not always be arbitrarily applied. Patients need to consult a doctor before using for specific support advice. In addition, if you are prescribed to use it but find that your condition is not on the list of indications, please discuss with your doctor for specific explanations and instructions.
2. Dosage and how to use Indomethacin
Indometacin is a pill for oral use. Please consult your pharmacist or doctor directly before taking this medicine. The time and dose of the drug may need to be adjusted for each person, so you should not use it without specific instructions from your doctor.
Dosage of Indomethacin according to indications currently does not have guidelines for children. So for young children, ask your doctor about the feasibility of using this medicine before taking it. Here are some recommended adult dosages:
Treatment of osteoarthritis after mild or severe stage: Use dose 3 times daily. Treatment of acute pain around joints or tendons using a dose of 75 - 150mg per day depending on the degree of inflammation. This dose should not be used immediately, but should be divided into 3-4 times a day. Indometacin is used 3 times daily with a total dose of 150mg. Patients who need nocturnal pain relief can take the drug or put it rectally if the doctor allows with a dose of 100mg. Pain relief using the drug 3 times / day, the dose of 25mg each time. Treatment of gout is 50mg x 3 times/day. Indomethacin should not be combined with aspirin. Treatment of juvenile-onset arthritis is based on body weight, 1-2.5 mg/kg per day. Use no more than 150mg per day and the amount of medicine used during the day should be divided into 3-4 times. Premature babies who need to use Indomethacin should choose slow intravenous injection, the dose will be reduced depending on the specific situation.
3. Notes before taking Indomethacin
Indometacin is contraindicated in patients with a history of allergy to drugs or non-steroidal anti-inflammatory drugs. In addition, you need to check your health before taking the drug because some other contraindications are listed including:Severe liver failure; Women suspected of being pregnant; Women who are raising children; Peptic ulcer disease. If you have any contraindications, tell your prescribing doctor. Your doctor will prescribe another medication that will do the same thing, but won't affect your treatment or recovery.
If you have one of the following medical conditions, talk to your doctor for an early follow-up prevention plan:
Have an infection in any part of the body; Patients with psychotic symptoms; Epilepsy patients ; Patients with Parkinson's syndrome; Children under 15 years old; Elderly; People who have been treated for peptic ulcers; Patients with disorders of blood pressure index; Patients with coagulation dysfunction; Suspected at risk of heart failure. Indometacin is included in the list of toxic drugs in Group B. Therefore, it cannot be used without checking from a doctor. In addition, the drugs listed as toxic drugs have a serious risk of affecting the patient's health, so it should be noted.
Store Indomethacin in a cool, dry place. Indomethacin drugs have the ability to change pharmacology and pharmacokinetics when meeting with alkaline solutions and exposure to strong light sources. To avoid alteration of the drug's medicinal properties, always store the medicine in a tightly closed vial. The ideal temperature to store medicine is in the range of 15 - 30 degrees Celsius.
4. Indometacin side effects
Indometacin may have side effects in some patients. However, whether or not each patient is treated with Indomethacin should pay attention to the following manifestations:
Vomiting; Frequent nausea; Stomachache ; Anorexia ; Diarrhea ; Constipation ; Stomach ulcers; Stomach bleeding ; Stomach perforation. The side effects listed above may or may not be present. At the same time, these are not all the side effects that Indomethacin can cause for patients after taking it. Therefore, you should adhere to regular health checkups, follow-up examinations as directed by your doctor to early detect and take timely corrective measures.
5. Interaction with Indomethacin
Indometacin can interact when patients accidentally overdose. Usually, when overdosing, the doctor will speed up the elimination process or cause inhibition to reduce the effectiveness of the drug by a few medical methods such as:
Gastric lavage; Stomach aspiration; Diuretic ; Induce vomiting; Use activated carbon; Use laxatives. These solutions will help the elimination process of Indomethacin take place faster. At the same time, the drug concentration in the blood did not increase to the peak. In addition, if the patient has severe symptoms, other measures can be used such as:
Dialysis; Hemodialysis ; Blood transfusion. When using Indomethacin, patients should not combine more than one drug at the same time. You should note the following drugs that cannot be combined with Indomethacin:
Anticoagulants; Aspirin ; Blood sugar-lowering drugs; Ticlopidine; Lithium; Methotrexate. In particular cases, interactions other than those mentioned above may occur. Patients should actively discuss directly with the treating doctor for specific support.
Indometacin has anti-inflammatory and pain-relieving effects, but cannot be used in combination with other drugs without instructions and prescription from a doctor. To avoid serious health effects, you should always check and re-examine at the request of your doctor.
