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Imutac drug has the main ingredient is Tacrolimus, commonly used in the treatment of eczema, atopic dermatitis, ... Patients using Imutac may experience some unwanted effects such as itching, erythema, egg fish... Therefore, it is necessary to learn carefully about drug information before use.
1. What is Imutac?
Imutac is manufactured by Laboratorios Recalcine S.A. - CHILDREN. Imutac is a prescription drug, classified in the group of medicines for the treatment of dermatological diseases. The main active ingredient of Imutac is Tacrolimus.
Dosage form: Ointment for topical application, 0.1% content.
Packing form: Box of 1 tube 15g
2. Uses of Imutac
Pharmacodynamics: Tacrolimus is extracted from Streptomyces tsukubaensis, which is a macrolide. Tacrolimus is a potent immunosuppressant with limited antibacterial activity. However, the immunosuppressive mechanism of Tacrolimus has not been clearly studied.
In patients with atopic dermatitis, improvement in skin lesions during tacrolimus administration was associated with decreased Fc receptors in Langerhans cells as well as decreased T-lymphocyte overstimulation. Collagen synthesis was not affected by Tacrolimus.
Pharmacokinetics:
Absorption: When applied topically, Tacrolimus has no or very little systemic effects. The bioavailability of topical ointments is less than 0.5%. As the area of the skin is increased, systemic drug concentrations increase, but the extent and rate of absorption decrease as the skin heals. There is no evidence of tacrolimus accumulation during long-term treatment. Distribution: Tacrolimus has a very low systemic effect when applied to the skin. The plasma protein binding rate is 98.8%, but not clinically significant. Metabolism: Tacrolimus is not metabolised in the skin. When the drug is absorbed into the systemic circulation, Tacrolimus is metabolized by the liver to eight different metabolites. Elimination: Tacrolimus clearance is reduced in patients with severe hepatic impairment. The mean half-life with repeated dosing is 65-75 hours.
3. Indications and contraindications of the drug Imutac
Imutac is commonly used in the following situations:
Moderate to severe atopic dermatitis in patients over 16 years of age who have not responded to conventional therapies. Prophylaxis of recurrence and prolongation of flare-free time in patients with atopic dermatitis or exacerbations. For patients who have been treated for more than 6 weeks of flare-ups until the lesions are gone or are still mild, they will switch to maintenance therapy. Contraindications: Absolutely do not use Imutac in the following cases:
Hypersensitivity to any ingredient of Imutac. Children under 2 years old.
4. Dosage and how to use Imutac
Imutac is a prescription drug, so you need to strictly follow your doctor's instructions on dosage, route and duration of taking the drug. Do not change the dose on your own, use the drug in another way, or stop taking it on your own. In addition, you should not share Imutac with other people or give it to others to use even if they have the same symptoms as you.
Dosage:
For flare-ups: Imutac should not be used for long-term treatment, should be used short-term or intermittently. Use the drug as soon as the first symptoms of the disease appear to achieve good results. Use the drug until the lesions heal or when prescribed by the doctor, then switch to maintenance treatment. From 16 years of age and older: 2 times a day until the skin is gone or only mild skin lesions remain. Usually, symptoms of the disease improve after 1 week of taking the drug. If there is no improvement after 2 weeks, consult your doctor. Elderly: According to available clinical studies, no dose adjustment is required in this population. Maintenance treatment:
From 16 years old and up: 1 time / day, 2 days a week for areas of skin that are often sick. After 1 year, the patient's condition should be assessed and decided whether maintenance should be continued. If there are signs of recurrence, repeat treatment with 2 times / day. Elderly: According to available clinical studies, no dose adjustment is required in this population.
How to use:
Imutac is prepared in the form of an ointment, so patients only apply it on the skin, not drink it. Wash the damaged skin, apply a layer of Imutac ointment and massage gently. Do not cover the affected area after applying the medicine. Imutac can be used on the face, neck, and folds, except for the mucous membranes. What should I do if I miss a dose of Imutac?
When you miss a dose, apply another dose as soon as you remember. If it's close to the time of taking the medication, skip it. Do not apply a double dose to make up for a missed dose. What to do in case of an overdose of Imutac?
When there is an overdose, it is necessary to take the patient to the nearest medical facility for treatment. Bring all medications the patient has used to help make the diagnosis more accurate and faster.
5. Undesirable effects
In addition to the therapeutic effect, the drug Imutac may cause some unwanted effects during use such as:
Common: Skin irritation, burning, itching,... These symptoms usually go away after 1 week of medication. Uncommon: Pruritus, erythema infectiosum, paresthesia, rash, alcohol intolerance, ... Rare: Folliculitis, acne, herpes virus infection. In addition, you may experience other side effects that have not been listed or studied. Therefore, you should immediately contact your doctor if you have any unusual symptoms while taking Imutac.
6. Drug interactions
Concurrent treatment with more than one drug can cause synergism or competition between drugs or between drugs and food, resulting in changes in bioavailability, absorption, metabolism, effects, and effects. side effects of the drug. Therefore, you need to list and inform your doctor about the medications you are taking as well as your current medical conditions.
Imutac is applied topically to the skin, the concomitant use of other topical preparations or UV therapy has not been studied. Therefore, concomitant use of Imutac with UVA and UVB or PUVA should be avoided.
7. Some notes when using Imutac
Use of Imutac in pregnancy: There is not enough evidence about the safety of using Imutac in pregnant women. Therefore, Imutac should not be used during pregnancy unless directed by your doctor. Use of Imutac during lactation: Tacrolimus is secreted into breast milk when administered orally. The concentration of drug absorbed when applied topically is very low. However, Imutac should be used with caution during breastfeeding and should be consulted with a physician. Imutac has no or very little influence on the ability to drive or use machines.
8. Preservation of drugs
Store Imutac in the original manufacturer's packaging, in a cool, clean place away from direct sunlight, at a temperature below 30 degrees Celsius. Keep Imutac out of reach of children and objects. rearing, avoiding them not knowing how to chew can cause serious unwanted effects. Her Imutac perax has a shelf life of 24 months, do not use expired medicine or show signs of change in color, nature, taste, no labels. Above is all information about Imutac, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Imutac is a prescription drug, so patients should absolutely not buy drugs to treat at home because they may encounter unwanted side effects.
