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Heparigen belongs to the group of gastrointestinal drugs with the main ingredient being L-Ornithine-L-Aspartate, which is often used to detoxify, excrete nitrogen, promote muscle growth, and especially work to enhance liver function. , regenerate liver cells, stimulate the production of new cells to replace old damaged cells.
1. What is Heparigen?
Heparigen drug with main ingredient is L-Ornithine-L-Aspartate (LOLA), stable salt form of two amino acids ornithine and aspartic acid indicated in acute and chronic liver diseases such as cirrhosis, fatty liver, inflammation liver, associated with blood ammonia, especially in neurological complications (hepatic encephalopathy). LOLA has the effect of stimulating the synthesis of urea and glutamine rings, which play an important role in the detoxification mechanism of ammonia, removing extrahepatic ammonia from tissues to help protect liver cells. In addition, Heparigen also produces energy in the form of ATP, thereby improving the energy balance of the diseased liver. From the above uses, Heparigen is often indicated in the following cases:
Support for the treatment of elevated ammonia in the blood by excreting nitrogen, especially in hepatitis, cirrhosis, and hepatic encephalopathy. liver cell failure causing patients to lose appetite, fatigue, itching and discomfort Treatment of hepatic pre-coma and hepatic coma Some contraindications to Heparigen include:
Patients are sensitive to any component of the drug. Heparigen drug Patients with renal failure Patients with lactic acidosis, methanol intoxication, fructose-sorbitol intolerance, fructose 1,6-diphosphatase deficiency
2. Dosage of the drug Heparigen
Heparigen is made in the form of an infusion solution, so patients use the drug by slow intravenous injection, Heparigen can be mixed in any other infusion. Dosage of Heparigen depends on the treatment goal and the patient, specifically as follows:
Adults (>12 years old) with acute hepatitis: 1-2 ampoules (500mg/5ml)/day Adults ( >12 years) with chronic hepatitis or cirrhosis: 2-4 ampoules/day May increase dose depending on severity of disease Pre-coma disorder and hepatic coma: 8 ampoules/24 hours at a rate maximum infusion of 5 g/hour, do not use more than 6 ampoules in 500 ml of infusion In injectable form: 2 ampules (500mg/5ml) can be given slowly intravenously/day in the initial phase, the dose can be continued for 3 consecutive days. -4 weeks, combined with oral or infusion in severe cases.
3. Side effects of the drug Heparigen
In some patients when using Heparigen, side effects may occur such as:
Burning sensation in the larynx or nausea Risk of anaphylaxis when administered intravenously: difficulty breathing, panic , laryngeal edema, heart failure, cold hands and feet or congestive heart failure
4. Be careful when using Heparigen
Some general notes when using Heparigen include:
Monitor drug levels and urea levels in urine and blood in people using high doses of Heparigen Pay close attention to anaphylaxis when infusion Intravenous Do not use expired or damaged medicine Be careful when cutting ampoules because very small pieces of glass may fall into the solution Be especially careful when using Heparigen on patients during pregnancy or breast-feeding, consult your doctor to consider the potential benefits of the drug against the potential harm. about drugs or supplements that interact with drugs, but still should be careful with the accompanying food. Heparigen belongs to the group of gastrointestinal drugs with the main ingredient being L-Ornithine-L-Aspartate, which is often used to detoxify, excrete nitrogen, promote muscle growth, and especially work to enhance liver function. , regenerate liver cells, stimulate the production of new cells to replace old damaged cells. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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