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L-Ornithin-L-Aspartate is a precursor to create 2 amino acids, Ornithin and Aspartic Acid, which play an important role in a number of metabolic processes in the liver. This active ingredient is in the drug Heltec 3g. So what are the uses of Heltec 3g and how should it be used?
1. What is Heltec 3g?
Heltec drug is a product of Korea Pharma Co., Ltd., the main ingredient is 3g L-Ornithin-L-Aspartat.
Heltec 3g is indicated for use in the treatment of comorbidities and conditions secondary to reduced liver detoxification function (such as cirrhosis), latent hepatic encephalopathy or clinically manifest hepatic encephalopathy. ready.
Heltec 3g is prepared in the form of powder mixed into oral solution and packed in boxes of 10 packs, 3g each.
2. Uses of Heltec 3g
Indications for use of Heltec include comorbidities and conditions secondary to reduced liver detoxification function (such as cirrhosis), underlying hepatic encephalopathy or symptomatic hepatic encephalopathy.
3. Pharmacological characteristics of the drug Heltec 3g
L-ornithin-L-aspartate in Heltec drug exhibits in vivo activity in the form of 2 amino acids, Ornithin and Aspartic Acid, through 2 main liver detoxification mechanisms, namely urea synthesis and glutamine synthesis: Urea occurs in hepatocytes in the area around the portal vein. Here, the amino acid Ornithine acts as an activator of two enzymes Ornithine carbamoyltransferase and Carbamoyl phosphate synthetase, and is also a substrate of urea synthesis; Glutamine synthesis takes place in perivenous hepatocytes. Especially in pathological conditions, aspartic acid, other dicarboxylic acids and metabolites of Ornithin are increased absorption into hepatocytes, thereby used to bind Ammonia in the form of Glutamine. Glutamic acid acts under physiological as well as pathological conditions as an amino acid that binds ammonia. The amino acid glutamic acid present in the body is not only a waste product for ammonia, but also plays an important role in activating the urea cycle (the exchange of glutamine between cells). Under physiological conditions, 2 amino acids in Heltec 3g, Ornithin and Aspartic Acid, are used unlimitedly for urea synthesis.
Animal experiments have shown increased glutamine synthesis to account for the mechanism of ammonia depletion. In individual clinical studies, an improvement in the ratio of branched chain amino acids to aromatic amino acids was observed.
Pharmacokinetic characteristics of the drug Heltec 3g: L-ornithin-L-aspartate is rapidly absorbed, then broken down into Ornithin and Aspartate. These two amino acids both have short half-lives, ranging from 0.3 to 0.4 hours. Small amounts of Aspartate appear in the urine unchanged.
4. Instructions for using Heltec 3g
4.1. How to use Heltec 3g Patients need to dissolve the pack of Heltec 3g with a sufficient amount of liquid, which can be water, tea or fruit juice; Use the reconstituted solution during or after meals and should be taken immediately after reconstitution. 4.2. Dosage of Heltec 3g The usual dose in adults is 1 to 2 packs of Heltec 3g each time, up to 3 times per day; Children and adolescents under 18 years of age: Experience in using Heltec 3g in this population is relatively limited; Dosage of Heltec is for reference only. To have the right dose, the patient should consult the doctor's instructions, note that the dose of Heltec 3g depends on the condition, the degree of disease progression in each specific case. 4.3. Overdose of Heltec 3g So far there have been no cases of L-ornithin-L-aspartate poisoning. However, patients who exceed the recommended dose of Heltec 3g and have abnormal symptoms may need appropriate treatment measures, and active monitoring to take timely measures.
4.4. Treatment when forgetting 1 dose of Heltec 3g The patient should take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take a double dose to make up for it.
5. Side effects of Heltec 3g
When using Heltec, patients are still at risk of experiencing unwanted effects (ADRs), including:
Digestive disorders such as vomiting, abdominal pain, flatulence, diarrhea; Pain in the extremities. Adverse effects of Heltec 3g are usually mild transient and do not require discontinuation of the drug.
6. Some notes when using Heltec 3g
Before using any medicine, including Heltec 3g, patients should carefully read the instructions for use and consult a doctor. One of the extremely important issues is the contraindications, including:
People with hypersensitivity to L-ornithin-L-aspartate or other ingredients contained in the product Heltec 3g ; Severe renal failure with serum creatinine greater than 3 mg/100 ml. Some issues with caution when using Heltec 3g:
Package of Heltec 3g contains aspartame, which is absorbed and broken down in the gastrointestinal tract and one of the dissolving substances is Phenylalanin. It can therefore be harmful if the user has phenylketonuria (a rare genetic disorder). In people with this disease, phenylalanine accumulates in the body because it cannot be eliminated; There are no laboratory or clinical data to evaluate the use of Aspartame in children under 12 weeks of age; Children and adolescents under 18 years of age: There are no studies on the use of Heltec 3g in this group of subjects; There are no data from reliable studies on the fertility risk of Heltec 3g ; Ability to drive and use machines: Depending on the medical condition, the patient's ability to drive and use machines may be affected when treated with Heltec 3g; Pregnancy: There is no clinical evidence for the use of Heltec 3g during pregnancy, and L-ornithin-L-aspartate has not been adequately studied in animals for reproductive toxicity. Therefore, pregnant women should avoid using Heltec 3g. Where treatment with Heltec 3g is considered essential, a careful assessment of the benefit and risk of harm during pregnancy is required; Lactation: There is no evidence that L-ornithin-L-aspartate in Heltec 3g is excreted in breast milk. Therefore, it is best to limit the use of Heltec 3g for women who are breastfeeding. Where use is mandatory, a careful assessment of the benefits and risks to the nursing infant must be made.
7. Heltec 3g . drug interactions
Until now, no studies on the interactions of Heltec 3g have been performed. At the same time, no drug interactions have been recorded during the patient's use.
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