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Glucarbose 100mg belongs to the group of Hormonal and Hormonal drugs, often used as an adjunct to diet and exercise to treat type 2 diabetes. Before using Glucarbose 100mg, patients need to understand the information. information about uses, usage, dosage and precautions for use.
1. What is Glucarbose 100?
Glucarbose 100mg is a pharmaceutical product manufactured at Mebiphar Pharmaceutical and Medical Biology One Member Company Limited, Vietnam. Glucarbose 100mg belongs to the group of Hormonal and Hormonal drugs with the main ingredient being Acarbose 100mg used as an adjunct to diet and exercise in the treatment of type 2 diabetes.
The drug is prepared in tablet form and is packaged in a box of 3 blisters x 10 tablets, each containing 100mg of acarbose.
2. Uses of Glucarbose 100mg
2.1 Effect of drug ingredient Acarbose is an anti-diabetic tetrasaccharide, capable of inhibiting intestinal alpha-glucosidase enzymes, especially sucrase, this ingredient slows down the digestion and absorption of carbohydrates. As a result, postprandial blood glucose rises slowly, reducing the risk of hyperglycemia, and this concentration fluctuates less during the day.
When using single-drug therapy, Acarbose will reduce the mean concentration of Hemoglobin glycosylate (about 0.6 - 1%). A decrease in hemoglobin glycosylate will correlate with a reduced risk of microvascular complications in patients with diabetes. Acarbose does not inhibit the enzyme lactase, nor does it cause lactose intolerance.
Unlike sulfonylurea antidiabetic agents, acarbose does not increase insulin secretion. Acarbose also does not reduce fasting blood glucose when used as monotherapy because the mechanism of action of acarbose and sulfonylurea antidiabetic agents is different. Acarbose does not cause weight gain, reducing the insulin-directed effects of sulfonylureas.
However, because Acarbose mainly slows glucose absorption, the drug does not lose many calories and does not cause weight loss in diabetics and normal people. Acarbose may be added to help improve glycemic control in diabetics who have been poorly treated with other conventional therapies.
2.2 Indications Monotherapy: Glucarbose 100mg is used as an adjunct to diet and exercise to treat type 2 diabetes (non-insulin dependent) in people with hyperglycemia (especially post-hyperglycemia). when eaten) cannot be controlled by diet and exercise. |
Combination: Glucarbose 100mg in combination with Sulfonylure as adjunct to diet and exercise in the treatment of type 2 diabetes in people with hyperglycemia not controlled by Acarbose or Sulfonylure alone.
2.3 Contraindications Glucarbose 100mg is contraindicated in the following cases:
Patients with hypersensitivity to Acarbose or components contained in the drug's excipients. People with intestinal infections, accompanied by ulcers. Do not use for people who are prone to diseases due to increased abdominal pressure (hernia) because this medicine has the ability to create gas in the intestines. Liver failure and elevated liver enzymes should not be used. The patient has low blood sugar. Patients with diabetes complications of ketoacidosis. Pregnant and lactating women.
3. Usage – Dosage
How to use:
Glucarbose is made in tablet form, so it should be taken orally. The drug should be taken at the beginning of a meal with a small amount of water or can be quickly taken with the first piece of food in the meal. Dosage:
Glucarbose 100mg is only used according to the doctor's prescription, adjusted according to the tolerability and response of each patient, the usual dose is as follows:
The usual starting dose of Glucarbose 100mg in adults: 25 mg and then gradually increase the dose every 4 - 8 weeks until the desired postprandial glucose concentration is reached or a maximum dose of 50 mg 3 times/day (for patients weighing less than 60 kg) or 100mg x 3 times/day (for patients weighing over 60kg). Maintenance dose: Take 50-100mg x 3 times/day. Note: The dose of Glucarbose 100mg above may be changed by the doctor, adjusted according to the tolerance and response of each patient. Therefore, consult your doctor for advice on the most specific and effective dose of the drug.
4. Side effects
Most of the side effects when taking Glucarbose 100mg are gastrointestinal:
Common, ADR > 1/100: Abdominal bloating, diarrhea, broken stools, abdominal distension, abdominal pain and nausea. Uncommon, 1/1000 < ADR < 1/100: Skin rash and pruritus, abnormal liver function test. Rarely, ADR < 1/1000: Jaundice and hepatitis. Note: Please notify your doctor immediately when you experience the above side effects during the course of taking the drug for advice and timely and effective treatment.
5. Drug interactions
During treatment with Acarbose, foods containing table sugar (cane sugar) will often cause abdominal discomfort or sometimes diarrhea, because carbohydrates increase fermentation in the colon. Acarbose may interfere with the absorption or metabolism of iron. The mechanism of action of Acarbose and the antidiabetic drugs Sulfonylure or Biguanide is different. Therefore, their effect on blood glucose control is additive when used in combination. Acarbose should not be used concurrently with antacids, cholestyramine, intestinal absorbers and digestive enzymes, because these drugs may reduce the effect of Acarbose. In order to avoid interactions between drugs that affect the effects of Glucarbose 100mg, please inform your doctor about the drugs you are using, including medicine for disease or functional food for guidance and indications. specifically from your doctor.
6. Notes and cautions
In order to use Glucarbose drugs to achieve the best effect and safety, patients need to be cautious and pay more attention to the following issues:
Use the drug according to the doctor's prescription and prescription, do not arbitrarily Adjust dosage or stop medication, stop treatment without doctor's prescription. Liver transaminases should be monitored during treatment with acarbose because liver enzyme elevations have been reported. Hypoglycaemia may occur when acarbose is used concomitantly with a sulfonylurea antidiabetic agent or insulin. When hypoglycemia occurs, treat with oral glucose (dextrose) without sucrose because glucose absorption will not be inhibited by acarbose. Acarbose has no effect when used alone in diabetic patients complicated by acidosis, hyperketosis, or coma. The drug has little or no effect on the ability to drive and use machines, so it can be used safely for this subject.
7. Handling missed dose, overdose
Missed dose: Patients should take as soon as they remember, but if it is almost time for the next dose, take the next scheduled dose and skip the missed dose. Do not take a double dose to make up for a missed dose in order to avoid an increase in side effects or an overdose.
Overdose: When Glucarbose 100mg is taken with water and/or food containing carbohydrates, an overdose can cause bloating, flatulence and diarrhea. In case of overdose, treat symptoms, and food and drinks containing carbohydrates should be avoided for 4-6 days after the overdose.
In case of emergency and danger, take the patient to the nearest medical center for examination and timely treatment.
8. Preservation of drugs
Glucarbose medicine 100mg should be stored in a dry place with a temperature not exceeding 30 degrees Celsius and not exposed to sunlight. Besides, it is also not recommended to store medicine in the bathroom or refrigerator because this is a place with high humidity that easily affects the preservation process of medicine. It is necessary to keep the medicine out of the sight of small children to prevent children from playing and taking the wrong medicine, which affects the health of the child. Do not throw it into the toilet or flush it under your daily household tap, but contact your doctor or local waste disposal company for advice on how to safely dispose of medicine when it is no longer in use. Above is all information about Glucarbose 100mg drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Glucarbose 100mg treatment at home because there may be unwanted side effects.
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