This is an automatically translated article.
G-Pandom is made in the form of hard capsules, with the main ingredients including Pantoprazol and Domperidone. The drug is used to treat bloating, indigestion caused by gastric hypersecretory syndrome, peptic ulcer,...
1. Uses of G-Pandom
Each G Pandom tablet contains Pantoprazol sodium equivalent to Pantoprazol 40mg (in the form of enteric coated pellets) and Domperidon 10mg (in pellet form). Pantoprazole is a proton pump inhibitor, which blocks the final stage of acid production in the stomach. This effect is dose related, resulting in inhibition of basal acid secretion and stimulated acid secretion by all agents. Domperidone increases the period of contraction of the antrum - duodenum, accelerates gastric emptying, and increases esophageal sphincter tone.
Indications for the use of G-Pandom:
Treatment of symptoms of abdominal fullness and distention due to delayed gastric emptying in some diseases such as: peptic ulcer, gastric acid secretion syndrome, reflux gastroesophageal reflux. Contraindications to the use of G-Pandom:
Patients with a history of hypersensitivity to the drug's components; Patients with prolactin-releasing pituitary tumors; Patients with liver failure, kidney failure; People with gastrointestinal bleeding, intestinal perforation, mechanical intestinal obstruction; Concomitant use of Pantoprazol with atazanavir.
2. Usage and dosage of G-Pandom
Usage: Orally. Patients should take the drug about 30 minutes before meals for the best effect.
Dosage: 1 tablet / time / day.
Overdose: When Pantoprazole overdose and clinical symptoms of toxicity, the patient will be applied the normal detoxification rules. When domperidone overdose, the patient manifested dizziness, disorientation and extrapyramidal reactions. There is currently no specific antidote for Domperidone. Patients can be gastric lavage or activated charcoal, combined with supportive measures and close medical care. Alternatively, anticholinergics and antiparkinsonian drugs can be used to control extrapyramidal reactions.
3. Side effects of G-Pandom
Normally, patients rarely experience side effects of G-Pandom if they follow the right dose and treatment time. However, in the process of taking the drug, the patient may still face the risk of experiencing some side effects such as:
Immune system: Hypersensitivity reactions; Endocrine system: Increased blood prolactin levels; Nervous system: Headache, dizziness, extrapyramidal disorders; Skin and mucous membranes: Rash, urticaria, skin pruritus; Digestive system: Gastrointestinal disorders (transient gastrointestinal spasms, diarrhea); Reproductive system: lactation, breast enlargement, amenorrhea. Patients should immediately inform their doctor about the side effects when using G-Pandom to have the most appropriate treatment intervention.
4. Be careful when taking G-Pandom
Before and while taking G-Pandom, the patient should note:
For patients who have used Domperidone for 2 weeks without any improvement in symptoms, they should consult a doctor; Patients with severe liver dysfunction, especially when using Pantoprazol for a long time, should monitor liver enzymes regularly during the use of G-Pandom. In case of elevated liver enzymes, the patient should stop taking the drug; There is currently no experience with the use of Pantoprazol in children; Before using Pantoprazol for the treatment of gastric ulcer, the risk of malignant gastric ulcer or malignant esophagitis should be excluded. The reason is that Pantoprazole can temporarily relieve the symptoms of malignant ulcers, leading to a delay in the diagnosis of cancer; Stomach acid is reduced due to proton pump inhibition, increasing the amount of bacteria normally in the digestive tract. Treatment with G-Pandom may lead to a slightly increased risk of gastrointestinal infections, particularly Salmonella and Campylobacter; In patients with Zollinger-Ellison syndrome and other pathological hypersecretory conditions, prolonged treatment with pantoprazole or other acid-suppressing agents may result in decreased B12 absorption due to decreased or deficient acidosis. taste; There is not enough experience with the use of pantoprazole and domperidone in pregnant and lactating women. Therefore, G-Pandom should only be used in this group of people after the doctor has weighed the benefits and risks. If the mother is taking the drug, she should stop breastfeeding.
5. G-Pandom drug interactions
Some drug interactions of G-Pandom include:
Domperidone is metabolized by the enzyme CYP3A4. Studies have shown that the concomitant use of Domperidone and inhibitors of the CYP3A4 enzyme may further increase the serum concentration of Domperidone; Anticholinergic drugs may inhibit the effects of domperidone. If a combination of these drugs is required, the patient should take atropine after taking Domperidone; If Domperidone is used with antacids or acid secretion inhibitors, domperidone should be taken before meals, antacids or inhibitors of acid secretion should be taken after meals; Pantoprazole alters the absorption of other drugs administered concomitantly if their absorption is pH dependent (eg, Ketoconazole); Concomitant use of proton pump inhibitors including pantoprazol with atazanavir is not recommended; Pantoprazole is metabolised in the liver by cytochrome P450 enzymes. Although studies have shown that Pantoprazol has no significant effect on cytochrome 450, the possibility of interaction with other drugs metabolised with cytochrome 450 enzymes cannot be excluded. During the use of G-Pandom, patients should adhere to Strictly follow the doctor's instructions to achieve the best treatment effect and avoid dangerous incidents.
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