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Fungiact is a vaginal tablet with the main ingredients being Metronidazol, Neomycin Sulphate and Nystatin. The drug is used in the treatment of gynecological inflammatory diseases.1. What is Fungiact?
One Fungiact suppository contains: 500mg Metronidazol + 65,000 IU Neomycin Sulphate + 100,000 IU Nystatin and excipients. In particular, each drug ingredient has its own unique use such as:
Metronidazol: An antibiotic with activity against sensitive bacteria and protozoa. The drug is used in the treatment of vaginitis caused by Trichomonas (a vaginal infection caused by sexually transmitted parasites) and bacterial vaginosis ; Neomycin Sulphate: A bactericidal antibiotic. The Neomycin component is actively transported across the bacterial cell membrane, binds to a specific protein receptor located on the 30S subunit of bacterial ribosomes, and acts on the initiation complex between the 30S subunit and the RNA via the 30S subunit. information, inhibiting protein synthesis, leading to misreading of DNA. Therefore, it synthesizes inactive proteins Nystatin: As an antifungal antibiotic, it can inhibit or kill fungi depending on the concentration and sensitivity of the fungus. The mechanism of action of Nystatin is to bind to the sterol groups in the fungal cell membrane, resulting in the cell membrane no longer functioning as a selective barrier, causing the lack of essential cellular components. Indications for use of Fungiact:
Treatment of gynecological infections: Bacterial infections, fungal infections, vaginitis, vaginitis and vulvovaginitis caused by Candida. Contraindications to using Fungiact:
People who are sensitive to the ingredients of the drug; Pregnant women in the first 3 months.
2. Usage and dosage of Fungiact
How to use: Put the medicine deep into the vagina. Specifically:
Pull the set lever as far as possible and then place the pill in the center of the clamp of the applicator; Insert the tablet container carefully as far into the vagina as possible (preferably in the lying position); Push the insertion lever up to the level, slowly drop the tablet into the vagina and remove the applicator; After use, pull the set lever out of the applicator, wash with warm soapy water, rinse, and dry carefully. Dosage: Put 1 pill every night before going to bed for 8 consecutive days.
Overdose: There are currently no documented overdoses of Fungiact. Vaginal tablets can absorb a sufficient amount of the drug to have a systemic effect.
3. Side effects of Fungiact
When using Fungiact, patients may experience some side effects depending on the ingredients, specifically:
Metronidazol: Increased vaginal secretions, heart palpitations and causes angina, headache, dizziness, nausea, vomiting, indigestion, metallic taste in mouth, anorexia, diarrhea, constipation, urinary retention, C. albicans fungus, pelvic discomfort, vaginal dryness and burning, flatulence, stomach upset, depression, fatigue, dark urine, itchy skin, rash, dry mouth, thirst; Neomycin: Vaginal burning or itching, swelling, irritation, hearing loss, kidney damage,...; Nystatin: Vaginal burning or itching. When experiencing side effects due to Fungiact, patients should consult a doctor for timely and effective measures.
4. Be careful when using Fungiact
Before and while using Fungiact, patients should note:
Women who are breastfeeding should not take Fungiact because Metronidazol can be excreted in breast milk. Breastfeeding should be discontinued during and after 2 days of treatment with Metronidazole; During the use of Fungiact, if itching or sensitivity occurs, the patient should stop treatment; Patients should be cautious about drinking alcohol while using Fungiact tablets. This is because although Fungiact vaginal tablets have lower blood concentrations than the usual oral dose of Metronidazol, it is still difficult to avoid the risk of interaction with alcohol; Patients should not have sex while being treated with Fungiact; Fungiact should not be used during the first 3 months of pregnancy because metronidazole can cause some serious effects.
5. Fungiact drug interactions
Fungiact drug interactions are related to each ingredient of the drug. Some drug interactions of Fungiact include:
Metronidazol: Although the bioavailability of Metronidazole is usually low when administered vaginally, drug interactions can still occur. In this case, the doctor needs to change the dose or be cautious when prescribing the drug to the patient. It is best not to take Metronidazol with the following drugs: Disulfiram, amiodarone, fluorouracil, busulfan, mycophenolate mofetil, warfarin, carbamazepine, cyclosporin, lithium, cholestyramine, milk thistle, tacrolimus. In cases where concurrent use is required, the doctor will change the dose and frequency of use of 1 or both drugs; Neomycin : There are no complete data on the absorption of Neomycin through the vaginal mucosa but there is still the potential for absorption causing systemic effects and drug interactions. In this case, the doctor will need to change the dosage, be careful when prescribing the drug to the patient; Nystatin: Not absorbed through the vagina. Patients should inform their doctor if they are taking any medications to consider the risk of drug interactions and prescribe the most appropriate medication.
When using Fungiact, patients should strictly follow the instructions and instructions of the doctor to ensure the best treatment effect and limit the risk of unpredictable side effects.
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