Uses of Flohale 125 Inhaler

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Flohale 125 Inhaler is made in the form of an oral inhaler with the main ingredient being Fluticasone propionate. Flohale 125 Inhaler is used in the prevention of mild to severe asthma attacks.

1. What are the uses of Flohale 125 Inhaler?

1 inhalation dose of Flohale 125 Inhaler contains Fluticasone propionate 125mcg and excipients Tetrafluoroethane. Fluticasone propionate is a synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor effects. Fluticasone propionate, administered by inhalation at recommended doses, provides anti-inflammatory glucocorticoids in the lungs, reducing symptoms and asthma attacks without the adverse effects associated with systemic corticosteroids. Glucocorticoids are not effective in the treatment of acute asthma attacks but are used for maintenance treatment and prevention of asthma attacks. In addition, the drug is also used for patients who must use oral corticosteroids to gradually reduce the oral dose and then may not need to use the oral form anymore.
Indications for use of Flohale 125 Inhaler: Prevention of persistent asthma attacks from mild to severe, not used in the treatment of acute asthma attacks. Specifically:
Mild asthma: Patients use bronchodilators intermittently according to the regular daily dose regimen; Moderate Asthma: The patient has an unstable or worsening asthma attack despite taking asthma medications or using bronchodilators; Severe asthma: Patients with chronic, severe asthma who are dependent on systemic corticosteroids for symptom control. It has been reported that many patients significantly reduced or completely stopped using oral corticosteroids after taking inhaled fluticasone propionate; Children over 16 years of age: Children need to use asthma medications, including patients who cannot be controlled by current asthma medications. Contraindications to the use of Flohale 125 Inhaler:
People with a history of hypersensitivity to the ingredients and excipients of the drug.

2. Usage and dosage of Flohale 125 Inhaler

Patients need to take Flohale 125 Inhaler regularly, even if there are no asthma symptoms. The drug will take effect within 4-7 days. Caution should be exercised when patients perceive short-acting bronchodilators to have decreased effectiveness or have a need for more inhaled inhalers than usual.

2.1. How to use

The doctor will instruct the patient how to use the inhaler. If Flohale 125 Inhaler is used incorrectly, it will not help improve the patient's asthma. The drug is packaged in an inhaler with an air compressor and a mouth part for the patient to suck in when breathing. Specific instructions are as follows:
Try the inhaler:
When using the inhaler for the first time, the patient should try the inhaler. First, open the vial cap by gently pressing the side with your index finger and thumb, pulling out; To make sure the inhaler can work properly, the user shakes it well, turns the tip of the tube to the outside, and sprays 2 times into the air. If the medicine is not used for more than 1 week, do the same as above. Using an inhaler:
Start breathing slowly just before using the inhaler; Stand or sit upright while using the medicine; Open the cap of the ampoule, check the inside and outside, make sure the mouth of the ampoule is clean, there are no obstructions; Shake the ampoule 4-5 times to make sure the medication is evenly mixed in the ampoule; Hold the ampoule upright by placing your index finger above the tube, mouth of the tube facing down, exhale to make it more comfortable, hold to not inhale; Insert the ampoule deep into your mouth, close your lips and do not bite into the ampoule; Inhale slowly through your mouth, at the same time, gently press your finger on the tip of the inhaler to release the medicine, continue to inhale slowly and deeply; Hold your inhale and remove the inhaler from your mouth. Continue holding the inhalation for a few seconds or as long as possible; If the doctor prescribes 2 inhalations, the patient waits about 30 seconds and then starts the 2nd puff as directed above; After taking the medicine, it is advisable to rinse your mouth with some water and then spit it out; After taking the medicine, it is necessary to close the mouth of the medicine tube to prevent dust from sticking. The cover should be closed and firmly pressed into its proper position. You can practice in front of a mirror a few times. If you see a layer of fog coming out of the top of the tube or next to the mouth, start over. For children and people with weak hands, the inhaler can be used with both hands. Put 2 index fingers on the top of the tube, put 2 thumbs down on the mouth of the tube. If using this method still does not work, you should consult your doctor about using additional assistive devices.
Clean the inhaler: To keep the inhaler from getting clogged, users should clean the inhaler at least once a week. Specifically:
Remove the cap of the mouth of the medicine tube, do not remove the metal box from the plastic part; Use a clean cloth or a thin towel to wipe the inside and outside of the tube mouth and the plastic tube; Repeat the mouth of the tube, do not immerse the metal part of the tube in the water.

2.2. Dosage

For patients with mild asthma, the usual starting dose of Fluticasone propionate is 100 mcg/time x 2 times/day. Because Flohale 125 Inhaler has a 125mcg content, it cannot be used in this case. Patients need to use drugs with lower concentrations; For patients with moderate to severe asthma, the usual starting dose is 250 - 500 mcg (2-4 doses per inhalation with Flohale 125 Inhaler) x 2 times/day.; When further clinical effect is desired, a dose of 1000 mcg (8 doses per inhalation with Flohale 125 Inhaler) can be used twice daily. This dose should only be prescribed by a doctor with many years of experience in the treatment of asthma; The use of high doses above 1000mcg (500mcg / time x 2 times / day) requires the use of an aid to reduce side effects in the mouth and throat; Maintenance dose should be adjusted and used at the lowest effective dose in asthma control. Flohale 125 Inhaler does not require dose adjustment in the elderly or in patients with impaired liver or kidney function.
Overdose: If inhaled Flohale 125 Inhaler exceeds the recommended dose, the patient may experience temporary decline in kidney function. In this case, the patient does not need emergency care. Patients can continue to be treated with inhaled fluticasone propionate at a dose sufficient to control asthma . Usually, adrenal function recovers in a few days.
Chronic overdose of Flohale 125 Inhaler can lead to symptoms of hyperadrenocorticism, inhibiting hypothalamic-pituitary-adrenal axis function with muscle weakness, fatigue, and muscle pain. and joints, mental changes, anorexia, dyspnea, nausea and vomiting, hypertension, hyperglycemia, and dehydration. In this case, the patient should receive symptomatic and adjuvant treatment. When necessary, the dose should be gradually reduced before stopping the drug completely.
Missed dose: If you forget to take a dose of Flohale 125 Inhaler, the patient should take the next dose at the prescribed time, no need to make up for the missed dose.

3. Flohale 125 Inhaler side effects

When using Flohale 125 Inhaler, patients may experience some side effects such as:
Very common: Candida infection in the throat; Common: Irritation of the mouth, throat, hoarseness, pharyngitis, oral lesions, nasal congestion, sinusitis, upper respiratory tract infections, rhinorrhea; Uncommon: Bronchitis, nausea, vomiting, urticaria; Rare: Candida infections of the nose, throat, esophagus, bronchospasm; Very rare: Difficulty sleeping or nervousness, excitement, irritability, joint pain, hyperglycemia,... Reactions in patients that may require urgent treatment such as allergic conditions: Skin itching, erythema skin, rash-like urticaria, swelling of face, lips, tongue, mouth or throat, difficulty breathing, difficulty swallowing, rash, pruritus, dizziness, mild headache, pulse collapse,...
Patient should report Immediately tell your doctor about the side effects encountered when using Flohale 125 Inhaler for quick and appropriate treatment interventions.

4. Be careful when using Flohale 125 Inhaler

Some notes for patients to remember before and while taking Flohale 125 Inhaler:
The control of asthma should follow a step-by-step treatment program, the patient's response needs to be controlled clinically. by lung function tests; The patient's inhaler technique should be checked regularly to ensure that the patient has performed correctly and evenly, combining inhalations and inhalations to deliver the optimal amount of medication to the lungs. The inhaler is designed to be used in an upright position, so when spraying, the patient should stand or sit, not lie down; Careful consideration should be given to increasing the dose of corticosteroids; Do not use Flohale 125 Inhaler for the symptomatic relief of acute asthma attacks requiring rapid-acting bronchodilators. The patient should have on hand a short-acting and rapid-acting inhaled bronchodilator to relieve symptoms of an acute asthma attack; There is a risk of systemic effects when inhaled corticosteroids are used, especially if high doses are used for a long time. These side effects include: Adrenal insufficiency, Cushing's syndrome, growth retardation in children, decreased percentage of bone mineral, psychomotor disturbances, glaucoma, sleep disturbances, depression, anxiety. Europe. Therefore, the dose of corticosteroids should be regularly reviewed to minimize the effect of asthma control; Children on long-term use of Flohale 125 Inhaler should have their height checked regularly. If the child is found to be slower than normal, the dose should be reduced, only the lowest effective dose should be used; When using Flohale 125 Inhaler in high doses (over 1000mcg/day), patients should be advised to use it with an aid to reduce side effects in the mouth and throat. However, more systemic absorption is possible through the lungs, so it should be noted that a fractional dose inhaler with an assistive device may increase the risk of systemic side effects, which may require dose reduction; The benefit of inhaled fluticasone propionate is to reduce the need for oral steroids. However, patients switching from oral steroids with adrenal insufficiency should continue to monitor this risk for some time. Consideration should be given to determining the extent of impairment and appropriate treatment; When there is no response, severe asthma attacks should be considered, and if necessary, the dose of Fluticasone propionate should be increased or additional oral drugs and antibiotics should be used if an infection is present; During treatment with Fluticasone propionate, patients should not stop taking the drug suddenly; Use caution when administering inhaled corticosteroids to patients with latent or active respiratory tract infections; Children are more prone to hypothalamic-pituitary-adrenal axis deficiency, Cushing's syndrome than adults. Symptoms of adrenal insufficiency include growth retardation and failure to gain weight. Therefore, when using drugs for children, it is necessary to limit the dose to the minimum to achieve the therapeutic effect; There are no studies on the use of Fluticasone propionate in pregnant women. The benefits and risks should be weighed when it is necessary to administer this drug to a pregnant woman; There are no studies on the use of Fluticasone propionate in nursing mothers. The benefits and risks should be weighed when it is necessary to use the drug in lactating women; Use caution when driving or operating machinery if Fluticasone propionate affects vision, mobility or alertness.

5. Flohale 125 Inhaler drug interactions

Drug interactions can affect the effectiveness of treatment or increase the side effects of one or more drugs. Some drug interactions of Flohale 125 Inhaler include:
Ritonavir may increase fluticasone propionate plasma concentrations. Therefore, the concomitant use of these two drugs should be avoided unless the efficacy outweighs the systemic side effects of corticosteroids. The risk of corticosteroid side effects is increased with concomitant use of other CYP3A4 inhibitors; Cytochrome P450 3A4 inhibitors (erythromycin and ketoconazole) cause mild or negligible increases in fluticasone propionate concentrations but no reduction in serum cortisol levels. However, caution should be taken when administering Fluticasone propionate concomitantly with cytochrome P450 3A4 inhibitors. When using Flohale 125 Inhaler, the patient should strictly follow all the doctor's instructions on dosage and how to use the drug. If there are any doubts about the use of the drug, the patient should ask the doctor immediately, should not change the dose or stop taking the drug on their own to avoid the risk of adverse effects on the patient. health.

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