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Fisiodar is an anti-cancer drug indicated in the treatment of chronic B-cell lymphoma. So what does Fisiodar do and how is it used?
1. What is Fisiodar?
Fisiodar with the main ingredient is Fludarabine phosphate (2F-ara-AMP) this is a substance that opposes the synthesis of purine nucleotides. This will inhibit DNA synthesis of cancerous cells in the bone marrow and inhibit ribonucleoside diphosphate reductase.
In the treatment of chronic lymphocytic leukemia, after a single oral dose of 50mg, 70mg or 90mg Fisiodar. The maximum concentration of the drug in the blood is reached 2 hours after oral administration. The drug is metabolized in the liver and excreted in the urine depending on the glomerular filtration rate of the individual patient.
2. Indications of the drug Fisiodar
Fisiodar is indicated for the treatment of B-cell chronic lymphocytic leukemia (B-CLL) after a patient has been treated with an alkylating agent without a response or the disease continues to progress.
3. Contraindications of the drug Fisiodar
Fisiodar is contraindicated in the following cases:
The patient is allergic to the Fludarabine phosphate component of the drug. Patients with renal failure glomerular filtration rate < 30 mL/min. The patient is suffering from decompensated hemolytic anemia. Pregnant and lactating women should not use the drug because it crosses the placental barrier and breast milk.
4. Notes when using Fisiodar
During the use of Fisiodar, the patient should pay attention to the following:
The patient may be in poor condition when using the drug, causing fatigue, increasing body weakness. Patients with severe bone marrow failure, impaired resistance, and prone to infections should be cautious when using Fisiodar. In patients with hepatic and renal impairment, appropriate dose adjustment should be considered. Skin cancer patients are at increased risk of skin side effects. Elderly people using the drug should closely monitor the reactions on the central nervous system. During drug treatment Fisiodar do not inject vaccines that cause increased toxicity.
5. Drug interactions of Fisiodar
Some possible drug interactions when using Fisiodar, are:
Pentostatin increases lung toxicity when used with Fisiodar. Fisiodar reduces the effect of Digoxin on the cardiovascular system. Dipyridamole and adenosine inhibitors will reduce the effect of Fisiodar. Palifermin aggravated oral mucosal ulcers when combined with Fisiodar. Patients who have been treated with Cytarabine before using Fisiodar will reduce the metabolism of Fludarabine and reduce its effectiveness.
6. Dosage – How to use Fisiodar
6.1 How to take Fisiodar before or after a meal, the patient needs to swallow the tablet whole with water, do not chew, break or crush the tablet to use.
6.2 Dosage Adults: 40 mg/m2 body area/day; Take the pill for 5 consecutive days of each 28-day cycle. Usually 6 to 8 cycles of treatment. Patients with non-Hodgkin lymphoma increase the dose as directed by their doctor. Patients with renal impairment glomerular filtration rate 30 to 70 ml/min: reduce dose by 20%. Do not use the drug in patients with glomerular filtration rate < 30 ml/min.
7. Side effects of Fisiodar
The undesirable effects that may occur when using Fisiodar are as follows:
On the cardiovascular system
Angina pectoris; Cardiac arrhythmias; paroxysmal supraventricular tachycardia; Thrombophlebitis, deep vein thrombosis, arterial aneurysm; Transient cerebral ischemia ; Heart failure, pericardial effusion (rare). On the nervous system
Drowsiness, drowsiness, somnolence; Fatigue, body weakness; Headache, memory loss; cerebellar syndrome; Depression, agitation; Peripheral neuropathy; Optic neuropathy; Brain hemorrhage , coma; On the skin
Rash, itching; erythema multiforme Increased sweating; Herpes simplex infection; Hair loss, scalp increased sebum secretion; Stevens-Johnson syndrome ; On the digestive system
Anorexia, nausea, vomiting; Abdominal pain, diarrhea, constipation; Inflammation of the oral mucosa, esophagitis, mucositis; Difficulty swallowing; Gallstones; elevated pancreatic enzymes; Liver failure; On the urinary - genitourinary system
Difficulty urinating, burning urine, urinary tract infections; Proteinuria ; Hemorrhagic cystitis; Renal failure (1%),. On hematology
Anemia; Decrease in neutrophil blood cell lines, thrombocytopenia; Hemorrhage, hemophilia, bone marrow fibrosis; Hemolytic anemia syndrome; Increased blood sugar; On the musculoskeletal system
Muscle fatigue, back pain; Osteoarthritis pain; Osteoporosis ; On the respiratory system
Cough, difficulty breathing; Upper respiratory tract infections, lobar pneumonia, bronchitis,...; Acute respiratory distress syndrome, pulmonary hemorrhage; Pulmonary fibrosis; In summary, Fisiodar is a drug for the treatment of chronic lymphocytic leukemia, which is mandatory by an oncologist. In addition to the therapeutic effect, the drug causes many unwanted reactions to the body, so do not arbitrarily use or change the dose of the drug. Besides, tell your doctor right away when you have any bad symptoms in your body.
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