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Fada Oxaliplatino is an anti-cancer drug, acting on the immune system, so it is indicated in the treatment of colorectal cancer. So what is Fada Oxaliplatino and how is it used?
1. What is Fada Oxaliplatino?
What is Fada Oxaliplatino? Fada Oxaliplatino's main ingredient is Oxaliplatin - an anti-cancer drug containing platinum, belonging to the alkylation group. Oxaliplatin inhibits the transcription of DNA synthesis, slowing or stopping the growth of cancer cells.
Oxaliplatin component has a broad spectrum of action, anti-tumor activity on many types of tumors, especially on colorectal tumors, causing cytotoxicity. The drug is used intravenously, after injection, the drug is rapidly distributed into the body's organs. The drug is then eliminated in feces and urine.
2. Indications of the drug Fada Oxaliplatin
Fada Oxaliplatino drug is indicated in the following cases:
Patients with colon cancer. Adjuvant treatment of stage III colon cancer in patients who have undergone radical surgery. Treatment of late stage colorectal cancer without surgery.
3. Contraindications of the drug Fada Oxaliplatin
Cases in which Fada Oxaliplatino should not be used:
Allergy to Oxaliplatin, platinum derivatives or any ingredient of the drug. Fada Oxaliplatino crosses the placenta and breast milk, so it is not recommended for pregnant and lactating women. Patients with renal failure with glomerular filtration rate <30ml/min should not take the drug. Note when using Fada Oxaliplatino drug
Fada Oxaliplatino drug must be prescribed and closely monitored by a specialist. Fada Oxaliplatino can cause pulmonary fibrosis. If the patient has symptoms of shortness of breath, dry cough, pulmonary infiltrates, the drug should be temporarily discontinued. Monitor liver function, blood count regularly before and while taking the drug. Fada Oxaliplatino should be used with caution in patients with renal failure. Elderly patients taking Fada Oxaliplatino drug are often more sensitive to some undesirable effects of the drug such as: fatigue, hypokalemia, diarrhea, dehydration, leukopenia. There are not enough studies to demonstrate the safety of Fada Oxaliplatino in pregnancy, lactation, and children. Therefore, this object is not recommended for use.
4. Dosage and how to use Fada Oxaliplatino
How to use: Fada Oxaliplatino is prepared as a dry powder for injection, should be used by intravenous injection or intravenous infusion. Do not come into direct contact with the drug during the preparation process, if it comes into contact with the skin or mucous membranes, it should be washed several times with clean water and soap.
Dosage
Usual dose in adults: 85 mg/m2 body, intravenous infusion over 2 to 6 hours. Use of antiemetics can be combined with dexamethasone 2 days before the start of the Fada Oxaliplatino dosing cycle. Treatment regimen Fada Oxaliplatino combined fluorouracil and leucovorin (FOLFOX4) is used for 2 consecutive days, can be repeated after 2 weeks. Supportive treatment of stage III colorectal cancer (with radical surgery): Use 12 cycles lasting 6 months.
5. Fada Oxaliplatino interactions with other drugs
Interactions of Fada Oxaliplatino can occur as follows:
Natalizumab, the live vaccine, when used with Fada Oxaliplatino will increase the concentration of the drug in the blood. The cytotoxic drug clozapine increases the risk of agranulocytosis when combined with Fada Oxaliplatino. Administration of the Fada Oxaliplatino regimen in combination with fluorouracil and leucovorin concomitantly with anticoagulants has the potential to prolong prothrombin time and INR. Renal and auditory toxicity is increased when Fada Oxaliplatino is combined with aminoglycosides, polymyxins, capreomycin, diuretics. Patients receiving trastuzumab may potentiate the effects of Fada Oxaliplatino . Echinacea reduces the effects of Fada Oxaliplatino. Do not dilute the drug with solutions containing chloride. Do not use aluminum infusion kits because aluminum destroys the activity of the platinum derivative of the drug.
6. Fada Oxaliplatin side effects
Side effects of the drug Fada Oxaliplatino may occur with the following frequency:
Common
Feeling tired, dizzy, headache. Sleep disorders . Anorexia, taste disturbance, epigastric pain, dyspepsia, flatulence, nausea, vomiting, diarrhea, constipation. Gastro-esophageal reflux, dysphagia, oral mucosal ulcers. Decreased blood cell lines, anemia Increased liver enzymes (SGOT, SGPT). Increased total blood bilirubin. Peripheral neuropathy. Joint pain. Symptoms of upper respiratory tract infection. Peripheral edema, allergic reactions, hypersensitivity, injection site reactions. Decreased blood potassium, blood clots causing embolism. Difficult urination. Uncommon
Anaphylaxis . Acute renal failure. Increased alkaline phosphatase. Rare
Thrombocytopenia due to immune allergy. Hemolytic anemia. Optic neuritis, decreased vision. Pancreatitis, bacterial enteritis. Interstitial lung disease. Thus, Fada Oxaliplatino is a cancer treatment drug indicated and monitored by oncologists. The drug blocks the growth of cancer cells, and is also toxic to cells and produces many side effects. Patients need to be closely monitored and use the drug according to the doctor's instructions.
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