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Exemestane Stada is used to treat breast cancer in women affected by blood estrogen levels in postmenopausal women. The drug blocks the formation of estrogen, so it is good for breast cancer cases that depend on this hormone.1. What is Exemestane?
The main ingredient of Exemestane Stada drug is Exemestan 25mg, which is made in the form of film-coated tablets.Exemestane is an irreversible aromatase inhibitor. Chemically, this drug is related to the natural substrate androstenedione. In postmenopausal women, the hormone estrogen is produced primarily by aromatase-mediated conversion of androgens in peripheral tissues. The reduction of estrogen levels through aromatase inhibition is an effective selective therapy for estrogen-dependent breast cancer in postmenopausal women. Exemestane acts through the mechanism of irreversible binding at the site of action of this enzyme, thereby inactivating the enzyme. In postmenopausal women, the use of Exemestane significantly reduces the concentration of estrogen in the serum. In postmenopausal women with breast cancer treated with 25 doses per day, serum estrogen levels decreased by approximately 98%.
Exemestane has no progestogen and estrogenic hormone activity. A possible weak androgenic effect due to the 17-hydrogen derivative has been observed mainly with high doses of the drug. In the trials Exemestane did not affect the adrenal biosynthesis of cortisol and aldosterone, so glucocorticoid or mineralocorticoid replacement was not necessary.
2. Uses of the drug Exemestane Stada
Exemestane Stada is indicated for use in the following cases:Exemestane is indicated for the treatment of newly invasive breast cancer, after menopause with estrogen positive in order to reduce the risk of breast cancer recurrence and cancer. contralateral breast. For the first-line treatment of hormone receptor-positive advanced breast cancer in postmenopausal women with physiologic causes or menopause caused by other causes. Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women following anti-estrogen therapy alone or in combination hormone therapy. Contraindications:
Exemestane Stada is contraindicated in patients with a history of hypersensitivity to the drug or to any of the excipients contained in the drug. Pregnant women and women who are breastfeeding.
3. Dosage and how to use Exemestane Stada
Usage: The drug is taken orally and taken after meals.Dosage:
For adults: Oral dose: Take 1 tablet equivalent to 25mg/day; drink 1 time. The drug should be maintained until there is evidence of tumor reduction. Patients with early-stage breast cancer require long-term drug therapy for up to 5 years with continued adjuvant therapy. If the tumor recurs, it is necessary to stop exemestan. Patients with advanced breast cancer must take exemestan until there are signs of good disease progression. The patient noted the need for vitamin D and calcium supplements. No dose adjustment is necessary for patients with impaired liver or kidney function. Children: Exemestane Stada is not recommended for use in children.
4. Undesirable effects of the drug Exemestane Stada
The side effects of the drug Exemestane Stada recorded include:Very common: Increased blood pressure; Fatigue, insomnia, pain, headache, depression; Sweating, hair loss; Hot flashes; Nausea, abdominal pain; Increased alkaline phosphatase; Athritis. Common: Edema, myocardial ischemia, angina pectoris; Dizziness, anxiety, fever, confusion, decreased sensation; Dermatitis, itching, rash; Weight gain; Diarrhea, vomiting, loss of appetite, constipation, increased appetite, indigestion; Urinary tract infections ; Bilirubin increased; Back pain, lower extremity pain, osteoarthritis, muscle weakness, osteoporosis, pathological fractures, dysarthria, carpal tunnel syndrome, cramps; Vision disturbances; Creatinine increased; Shortness of breath, cough, bronchitis, rhinitis, sinusitis, upper respiratory tract infection; Flu-like syndrome, increased sweating, lymphedema, bacterial infection. Uncommon: Endometrial hyperplasia; Increase GGT enzyme; Neurological diseases; Thrombocytopenia, leukopenia are common in patients with advanced cancer; cartilage damage, thromboembolism, increased liver transaminases, twitching fingers, uterine polyps. You may also experience other unwanted effects while taking the medicine. Notify your doctor if you experience side effects while using the drug.
5. Precautions when using Exemestane Stada
To prevent osteoporosis caused by estrogen deficiency, it is necessary to monitor bone density, supplement vitamin D and calcium in the daily diet or supplement with oral supplements. This drug should not be used in premenopausal women as efficacy and safety have not been evaluated in this patient population. Therefore, when used clinically, it is necessary to ascertain that this patient is in a postmenopausal state by testing the levels of LH, FSH and estradiol. Exemestane should not be used concurrently with drugs that contain estrogen because they reverse the pharmacological effects of Exemestane. Effects on People Driving and Using Machines: Exemestane is not expected to impair the ability of patients to drive and use machines. However, drowsiness, asthenia, somnolence, and dizziness have been reported during the use of the drug. Use caution when driving or operating machinery.6. Interactions with other drugs
Some cases of drug interactions include:Hypericum perforatum (St. John's grass) reduces exemestane blood levels. The drugs Cimicifuga racemosa and Angelica sinensis should not be used in women with estrogen-dependent breast cancer. This drug should not be used concurrently with estrogen-containing drugs, as these drugs reverse or reverse the effect of exemestane. Exemestan reduces the concentration and effect of the drug maraviroc (a drug that prevents HIV from entering CD4 cells by blocking the CCR5 receptor). Exemestane should be used with caution when co-administered with drugs that are metabolized by CYP3A4 and have a narrow therapeutic window. There is no clinical experience with the concomitant use of Exemestane with other antineoplastic agents. Storage: The drug should be stored at a temperature below 30 degrees Celsius and in a cool place, out of the reach of children.
Drug Exemestane Stada is an anti-cancer drug indicated for use by experienced doctors. Do not arbitrarily stop using, increase the dose or change the prescription of the doctor. Follow the treatment and visit regularly to control the disease well.
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