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Eltrombopag, also known as Promacta, belongs to the group of anti-cancer drugs and affects the body's immune system. Eltrombopag medicine contains the main active ingredient Eltrombopag and other excipients in a sufficient amount. The drug is available in the form of film-coated tablets.1. What is Eltrombopag?
Eltrombopag is also known as Promacta drug. Eltrombopag is a man-made protein used to treat low platelet counts (thrombocytopenia) in adults caused by idiopathic thrombocytopenic purpura (also called ITP). Eltrombopag is a Thrombopoietin receptor agonist that stimulates bone marrow cells to produce platelets.Eltrombopag is indicated for use in patients who do not respond adequately to Corticosteroids, immunoglobulins.
2. How to use the drug?
Eltrombopag is available in the form of tablets or liquid, used orally once a day. Eltrombopag should be taken on an empty stomach ie about 1 hour before or 2 hours after eating. Eltrombopag tablets should be swallowed whole, not crushed, chewed or broken. In case you miss a treatment dose, wait and take your next scheduled dose. Never take two doses at the same time to make up for a missed dose. It is important to make sure that you are taking the correct amount of Eltrombopag each time. Before each dose of treatment, it is important to check and compare the information to see if what you are taking matches what you have been prescribed. The recommended starting dose is 50 mg per day. People of East Asian descent or those with liver problems should be started at a lower dose due to the risk of hepatotoxicity. During treatment with Eltrombopag, your doctor will order a blood count test and evaluate your liver function.
3. Eltrombopag drug interactions
The following compounds significantly reduce the absorption of Eltrombopag and should not be consumed at least 4 hours before or 2 hours after use:
Dairy products or supplements or fortified juices calcium supplement. Antacids (used for heartburn or calcium supplements). Multivitamins or supplements that contain iron, calcium, aluminum, magnesium, selenium, or zinc.
4. How to store Eltrombopag
Store Eltrombopag in its original, labeled packaging at room temperature and in a dry place (unless otherwise directed by your treating physician or healthcare professional). Eltrombopag should not be stored in the medicine box. Keep the Eltrombopag container out of the reach of children and your household pets. In case of caregiver:
Caregivers should consider wearing gloves or pouring medication directly from their container into a lid, small cup. Caregivers should avoid touching the tablet. Remember to always wash your hands before and after giving the tablet to the person using it. People who are pregnant or breastfeeding should not prepare doses of Eltrombopag. Do not flush Eltrombopag tablets down the toilet or throw them in the trash.
5. Undesirable effects when using Eltrombopag
Here are some common or important side effects that can be experienced while using Eltrombopag:
5.1. Causes liver toxicity Eltrombopag can cause liver toxicity, which your doctor can monitor using blood tests to evaluate liver function. You should watch for signs of yellowing on your skin or eyes, dark or brown urine, swelling or pain in your abdomen, as these could be warning signs of liver toxicity.
5.2. Diarrhea Your doctor may recommend medications to reduce diarrhea. In addition, you can change your daily diet such as:
Try eating low-fiber foods like white rice and boiled or grilled chicken. Avoid eating raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber such as apple sauce, bananas (ripe), canned fruit, boiled potatoes, white rice, products made with white flour and oatmeal can help relieve diarrhea. Drink an average of 8 to 10 glasses of non-alcoholic, caffeine-free water each day to prevent possible dehydration. 5.3. Decrease in platelet counts after stopping the drug In clinical trials, some people had lower platelet counts when they stopped taking the drug than they did before taking the drug. This side effect is most likely to occur soon after you stop using Eltrombopag and can last for about 1 month. A lower than normal platelet count increases the risk of bleeding, so it is important to take precautions and monitor any bruising or bleeding that should be reported to your treating physician. .
5.4. Changes in vision Eltrombopag may cause new or worse cataracts. Your doctor may order an examination of your eyes before and during treatment. Symptoms of cataracts include blurred, blurred or blurred vision, trouble seeing at night, sensitivity to light, or seeing halos around lights.
5.5. Formation of blood clots Eltrombopag increases the risk of blood clots forming . Symptoms of increased blood clot formation include swelling, redness, or pain in the extremities, or difficulty breathing. If you experience symptoms of these problems, you should contact your treating doctor or seek medical attention immediately.
5.6. Nausea or vomiting a lot You can control vomiting after using Eltrombopag by changing your diet: limiting your intake of fatty, spicy or acidic foods (lemon, tomatoes, etc.) Orange). You can make a warm cup of ginger tea to ease the symptoms.
You should inform your treating doctor if you are unable to keep fluids down for more than 12 hours or if you feel light-headed or dizzy at any time.
5.7. Fatigue Fatigue is a very common health condition during cancer treatment, including cancer treatment with Eltrombopag. You may develop a feeling of exhaustion that often doesn't go away with rest. To reduce feelings of fatigue, you can add more rest time combined with a schedule of gentle exercise, focus energy and important activities of the day.
6. Effects of Eltrombopag on fertility
Exposure of the fetus to Eltrombopag can cause birth defects, so you should not become pregnant or father a child while taking this medicine. You should use effective birth control methods during treatment and for 7 days after treatment is completed. Even if your partner's menstrual cycle has stopped for women or you believe you are not producing sperm for men, you may still be able to conceive and conceive. You should not breast-feed while using Eltrombopag and for 7 days after the last dose. Above is all information about Eltrombopag drug. You should read the instructions for use carefully before using to avoid unwanted effects.
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References: oncolink.org
