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Durogesic 50 is used in the management of chronic and persistent pain. The drug is used quite commonly on the system of drugstores in the country, but many people are still wondering about the use, how to use and how to use the Durogesic 50 patch? Read through the article below to get the most accurate answer.1. What is Durogesic?
Durogesic 50 belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs. The drug has the main active ingredient Fentanyl 8.4 mg. Durogesic 50 is used to treat Gout and osteoarthritis. Durogesic comes in the form of a transparent rectangular patch consisting of 1 protective film and 4 layers including:Polyester film-coated backing System fentanyl drug storage system (2.5 mg/10 cm2), USP standard alcohol (0.1 ml/10 cm2) gelled with hydroxyethylcellulose. Ethylene vinyl acetate polymer film helps control the rate of fentanyl release Silicone adhesive film.
2. Uses of Durogesic 50
Active ingredient Fentanyl is a synthetic opioid with analgesic effects similar to Morphine. This active ingredient acts on the central nervous system through binding to opioid receptors, helping to block neurotransmission across the synapse and reduce pain.
Durogenesic 50 is used in the following cases:
Relieves chronic pain. Strong pain relief due to injuries requiring drugs such as multiple trauma, cancer. Strong pain relief requires the use of opioid analgesics. Do not use Durogesic 50 in the following cases:
Do not use Fentanyl for acute pain management or after surgery. Because there is no time to adjust the dose, the wrong dose can lead to unwanted effects or death. Patients with traumatic brain injury or those with increased intracranial pressure. Patients who are sensitive to fentanyl or the adhesive contained in the patch.
3. How to use Durogesic 50 properly
3.1. Dosage The dose of Durogesic patch depends on the condition of each patient and depends on the specific case such as:
Patients who have tolerated Opioids: Dosage is recommended to be adjusted up or down every 12 μg/h or so. 25μg/h for the desired therapeutic effect. Opioid unresponsive patients: The recommended initial dose should not exceed 25 μg/h. The standard dose is 12 μg/h. 3.2. How to use Durogesic 50 is prepared in the form of a transdermal release patch, so it will be applied directly to the skin to be treated. Priority should be given to healthy, non-irritating, hair-free skin and flat surfaces such as the arms and torso.
First, the patient needs to clean the area of the skin to be applied the medicine and dry it with a clean towel. Next, cut the outer pouch and peel off the film that protects the patch being careful not to touch the skin on the surface of the patch. When applying the patch, gently rub the edges of the patch to adhere to the skin. Note: Durogesic should be glued immediately after unpacking. It is recommended to hold the patch for 30 seconds so that the patch is firmly adhered to the skin. Durogesic is networked continuously for up to 72 hours. If more pain relief is needed, the new patch should be applied elsewhere after removing the previous patch.
4. What side effects does Durogesic 50 cause?
When using the drug Durogesic 50 may cause some unwanted effects as follows:
Decreased ventilation Inhibition of the respiratory center Respiratory rhythm disturbances (rapid breathing, rapid breathing, respiratory depression may lead to death) Gastrointestinal disturbances (diarrhea, vomiting/nausea, abdominal pain, constipation, gallbladder spasms) Anxiety, confusion, hallucinations Headache Tremors and paresthesias Rash, erythema Itching Slow heart rate , arrhythmia Lower blood pressure Sweating Urinary retention Drowsiness When experiencing any abnormal signs, the patient should stop taking the drug and immediately notify the doctor, pharmacist or go to the nearest medical facility for examination. and prompt treatment.
5. Durogesic drug interactions 50
During the use of Durogesic may occur some interactions as follows:
Combined with central nervous system depressants (opioids, anxiolytics, muscle relaxants, sedating antihistamines, tranquilizers). sedatives, anesthetics,...) or alcoholic beverages may increase undesirable effects such as hypoventilation, deep sleep/coma or hypotension. Concomitant use with CYP3A4 inhibitors (Itraconagole) may prolong the therapeutic effect of the drug as well as severe respiratory depression side effects. Concomitant use with stimulants such as: Rifampicin, Phenytoin, Phenobarbital will reduce the therapeutic effect of the drug. If the patient is taking MAOIs for treatment, they should be discontinued at least 14 days before taking Fentanyl. To ensure the safety of using Durogesic, it is best for patients to inform their treating doctor about any drugs they have been using to avoid possible drug interactions.
6. Notes when using and storing Durogesic 50
Durogesic 50 is a line of prescription drugs from doctors and pharmacists. Therefore, patients should only use the drug when prescribed by the doctor, should not arbitrarily use it without permission.
Should use Fentanyl when really needed in case of mild pain, the patient should use mild pain relievers, do not abuse strong pain relievers.
If the patient's condition is in remission, the patient should stop taking the drug slowly and with a prescription from a medical professional, not to stop taking the drug suddenly to prevent withdrawal symptoms.
Durogenesic 50 should be used continuously for 72 hours, applied to a different location than the previous one or repositioned after a few days.
Fentanyl side effects can be hallucinations. Therefore, do not use the drug for those who drive, operate machinery or work at height.
Fentanyl should be used with caution in patients who are using opioids for the first time, people with depression, alcoholism, liver failure, kidney failure, heart disease.
Currently, there are no reports showing the safety of the drug to the fetus. Therefore, in case of pregnant women should use Fentanyl with caution, should only use when the benefits outweigh the risks and consult your doctor before use.
Fentanyl has been reported to be excreted in human milk. Therefore, in the case of women who are breastfeeding, absolutely do not use the drug because it can cause respiratory failure for the newborn.
Use Fentanyl with caution in children, because its safety in this age group has not been established.
Case of the elderly: according to some data, this subject may be more sensitive to the drug than the young, the half-life is long, the clearance may be reduced. When using Fentanyl in this subject, careful observation should be made if signs of toxicity are observed and if necessary the dose should be reduced.
During the process of applying the Durogesic 50 patch, the patient should prevent the patch from being exposed to heat lamps, direct sunlight, saunas, mineral springs or hot whirlpools.
Use of the patch on febrile patients should be monitored for opioid side effects. If necessary, the dose of Durogesic should be adjusted.
Absolutely do not use Fentanyl that has expired. Patients should read the information carefully before deciding to take the drug.
The above article is useful information about Durogesic 50. Patients should carefully consult the drug information before deciding to use it.
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