This is an automatically translated article.
Duhemos is a drug used in cases of bleeding, to help stop bleeding and reduce bleeding. In addition, the drug can also be used in some other cases. To learn more about the use, use and note when using the drug, please refer to the article below.
1. Uses of Duhemos 500
The main ingredient of Duhemos 500 is tranexamic acid 500mg, prepared in the form of film-coated tablets.Tranexamic acid inhibits fibrinolysis, by inhibiting the activation of plasminogen to plasmin, so plasmin (substance with endogenous fibrinolytic effect) is not produced. The uses of the drug can be mentioned as:
Anti-plasmin effect Tranexamic acid binds strongly to the lysine binding site, which has an affinity for fibrin of plasmin and plasminogen, and inhibits the binding of plasmin and plasmin. plasminogen with fibrin. Therefore, fibrinolysis by plasmin is strongly inhibited. In the presence of anti-plasmin agents, such as a2-macroglobulin, in plasma, the antifibrinolytic effect of tranexamic acid is further enhanced. When bleeding occurs, the body activates hemostasis by vasoconstriction, activates intrinsic inflammation, creates a platelet plug to cover the bleeding site, the main component of which is platelets, then creates a platelet plug. Blood clot to fix this damage with the main component is fibrin fibers. Therefore, if inhibiting fibrinolysis will help to stop bleeding better.
Excessively increased hemostatic effect Plasmin will cause inhibition of platelet aggregation, breakdown of coagulation agents... but even a slight increase of plasmin causes specific degradation. fibrin signal occurred earlier. Thus, in normal bleeding situations, the presence of tranexamic acid induces hemostasis by eliminating fibrinolysis.
Anti-inflammatory and anti-allergic effects Tranexamic acid also inhibits the production of kinins and other active peptides... because the presence of plasmin can cause increased vascular permeability and inflammatory lesions
2. Indications and contraindications when taking Duhemos
Duhemos is indicated in some of the following cases:
Abnormal bleeding during and after surgery, in obstetrics and gynecology, urinary tract bleeding, hemorrhagic disease. Dysmenorrhea, menorrhagia, bleeding in prostate disease, hemolysis due to pulmonary tuberculosis, nosebleed. In addition, it can be indicated in the symptoms of diseases such as urticaria, drug allergy or drug poisoning. Cases of contraindications to taking Duhemos 500:
Patients with thrombotic diseases such as cerebral thrombosis, myocardial infarction, thrombophlebitis and patients with a predisposition to thrombosis such as a history of blood thrombosis, coagulopathy. The patient is on coagulation therapy. Patients with a history of severe allergic reaction to tranexamic acid or to any of the ingredients in duhemos. Severe renal impairment : Since the drug is mainly eliminated by the kidneys, there is a risk of drug accumulation in severe renal failure.
3. Dosage and how to use Duhemos
How to use: The drug is taken orally, taking the drug with a lot of water.
Dosage: The daily dose is about 250 - 4000 mg, the drug is divided into 3 - 4 times.
Dosage for Duhemos 500
Usual dose: Take 1 tablet/time, 2 to 3 times a day. Blood in the urine: Take 2 tablets / time, 2-3 times a day until there is no longer bleeding. Severe nosebleed: Take 2 tablets / time, 3 times / day for 4-10 days. Menorrhagia: Take 2 tablets/time, take 2-3 times/day for 3-4 days. Other procedures causing bleeding: Take 2 tablets/time, take 3 times/day. For people with renal failure and the elderly: It is necessary to adjust the dose accordingly depending on the filtering capacity of the kidneys. Note that this is a reference dose, you need to rely on your actual condition to get the most appropriate prescription from your doctor. Avoid the risk of blockage due to blood clot.
4. Duhemos side effects
When taking the drug may encounter some of the following side effects:
Common: Dizziness, digestive disorders such as nausea and vomiting, diarrhea. Rare: Causes changes in eye color perception. Hypersensitivity reactions such as difficulty breathing, urticaria, swelling of the throat, swelling of the face ... need immediate emergency treatment because there is a risk of life-threatening.
5. Notes when using Duhemos
People who need to be careful when taking the drug such as people with kidney failure of various degrees, people with urinary tract bleeding due to the upper urinary tract because there is a risk of renal embolism. In the elderly, because the elderly have reduced renal function, it is necessary to take measures to reduce the dose and monitor carefully.
For pregnant women: The safe use of drugs is not really clear, can cause bad effects such as miscarriage, teratogenicity, birth defects... to any stage of pregnancy development , especially during the first trimester. Therefore, it is best not to use the drug for pregnant women. In cases where it is imperative to stop bleeding, it is necessary to consult carefully with your doctor before deciding to use it.
Breastfeeding women: This drug should not be used for this subject, only when really needed and should stop breastfeeding when taking the drug.
Drug interactions can occur when used concomitantly with oral contraceptives containing estrogen, other drugs with hemostatic effects and enzymes that have a clotting effect, because of the risk of thromboembolism due to blood clots.
Hopefully, through the above information, you already know about the uses and precautions when using Duhemos 500. This is a drug prescribed and used under the direction of a doctor, you do not arbitrarily use it without being instructed. determined.
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