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Anesthesia is an important movement before surgery. There are many different anesthetic active ingredients, the most common of which is intravenous anesthesia with drugs such as Diprivan. So what does Diprivan do?
1. What is Diprivan?
Diprivan is a product of Astrazeneca S.P.A - Italy, the main ingredient is the active ingredient Propofol 10mg/ml. Diprivan is prepared in the form of an injectable suspension, each box contains 5 ampoules of 20ml volume.
2. What are the effects of Diprivan?
Propofol (chemical structure is 2,6-Diisopropylphenol) is a short-acting anesthetic agent with a fast induction time of about 30 seconds, and the patient's recovery from anesthesia is often rapid. . However, like most other anesthetics, the known mechanism of action of Propofol is relatively limited.
In general, moderate arterial hypotension and slight changes in heart rate have been observed with Diprivan for induction and maintenance of anesthesia. However, hemodynamic parameters are usually relatively stable during the maintenance of anesthesia and the incidence of adverse hemodynamic changes due to Diprivan is quite low. Although respiratory depression may occur following administration of Diprivan, any effects are similar with other intravenous anesthetics and are easily managed in clinical practice. .
Propofol in Diprivan has the effect of reducing blood flow to the brain, reducing intracranial pressure as well as metabolic processes in the brain. In particular, the effect of reducing intracranial pressure occurs more in patients with pre-existing raised intracranial pressure.
Recovery from anesthesia with Diprivan is usually rapid, patients often feel relief and there are very few cases of headache, nausea and vomiting after surgery, especially less when compared with other anesthetics. inhalation addiction. It is also worth noting that Propofol at clinically used concentrations does not inhibit the synthesis of hormones of the adrenal cortex.
3. Indications and contraindications of Diprivan
Indications of Diprivan :
Active ingredient Propofol is a short acting intravenous anesthetic so Diprivan is suitable for induction and maintenance of anesthesia; Diprivan may also be used for sedation in patients on ventilatory support in the intensive care unit (ICU); Diprivan is also indicated for the purpose of sedation for surgical and diagnostic procedures. Contraindications of Diprivan:
Patients with a history or known allergy to Propofol; Diprivan is not suitable for use in children under 3 years of age; Diprivan is contraindicated for sedation in children of any age with diphtheria or epiglottitis in intensive care.
4. Dosage of Diprivan
Diprivan dose for induction of anesthesia:
Adults: Intermittent injection of Diprivan 40mg every 10 seconds until required anesthesia is achieved. The total dose is 20-50mg/min; Children over 3 years of age need slow injection of Diprivan and monitor response; Children over 8 years old: Use Diprivan at a dose of 2.5mg/kg. Dosage of Diprivan in the maintenance of anesthesia:
Adults: Continuous intravenous infusion at a dose of 4-12 mg/kg/hour or intermittent injection of 25-50 mg Diprivan drug each time; Children over 3 years: Diprivan infusion rate is 9-15 mg/kg/hour. Dosage of Diprivan for sedation in the adult intensive care unit: Diprivan use should be limited to 3 days to 0.3-4 mg/kg/hour. Note that sedation does not apply to patients who are young children.
5. Diprivan side effects
Induction of anesthesia with Diprivan is usually mild with little arousal in the patient. The most commonly reported adverse effects of Diprivan are similar to the pharmacological reactions of the predictable anesthetic class, such as hypotension. Due to the nature of the anesthetic procedure and the condition of the patient in the intensive care unit, the associated adverse events may also be due to the procedure performed or to the patient's condition.
Very common side effects of Diprivan :
Pain at the injection site upon recovery from anesthesia, which can be minimized by the use of large veins in the arm and anterior ulnar fossa. When using Propofol, local pain can be reduced by using it in combination with Lignocaine; Hypotension: Occasionally some patients with this side effect require rapid infusion and a reduced infusion rate of Diprivan ; Bradycardia : Rarely patients present with this severe manifestation. In addition, some cases can lead to asystole; Transient apnea at the onset of anesthesia; Nausea and vomiting during recovery; Headaches during the recovery period; Discontinuation symptoms of Diprivan in children, including facial flushing, occur as a result of abrupt discontinuation of Propofol in the intensive care unit Uncommon Diprivan side effects:
Thrombophlebitis and phlebitis; Seizure-like movements, including convulsions and arching during induction, maintenance, and recovery periods; Rhabdomyolysis: Very rare cases of rhabdomyolysis have been reported when Diprivan was used at doses greater than 4 mg/kg/hour for sedation in the ICU; Pancreatitis; Fever in the postoperative period; Discoloration of urine after long-term use of Diprivan; Hypersensitivity, which can cause angioedema, bronchospasm, erythema and hypotension; Pulmonary edema ; Reports from the use of Propofol, in addition to recommended indications, for induction of anesthesia in neonates indicate possible cardiovascular and respiratory failure.
6. Diprivan drug interactions
It is necessary to reduce the dose of Diprivan when combined with other narcotic or sedative drugs. Diprivan should not be combined with inhaled anesthetics.
7. Attention when using Diprivan
The process of induction and maintenance of anesthesia with Diprivan must ensure absolute sterility.
Use Diprivan with caution in the following patients:
ASA grade 3 and grade 4; Debilitated, elderly patients; Patients with damage to the heart, lungs, kidneys or liver; The patient has a medical condition that causes decreased blood flow; Patients with a history of epilepsy; Patients dependent on Propofol or sensitive to the drug; Patients with impaired lipid metabolism or receiving other intravenous lipid solutions. Diprivan is a product of Astrazeneca S.P.A - Italy, the main ingredient is Propofol 10mg/ml. The drug is used as an anesthetic in some cases. To ensure effective use and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor and medical staff.
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