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Dilonas – prescription cancer drug. To ensure the safety of using Dilonas, users need to know some information about its uses, dosage and subjects to get the best treatment results.
1. What is Dilonas?
Dilonas – drugs that belong to the group of anti-cancer drugs and affect the immune system with prescription.
Dilonas has the main active ingredient Anastrozole 1mg and other excipients. Preparation of Dilonas in film-coated tablets, box of 3 blisters x 10 tablets.
2. Uses of Dilonas
Dilonas has the main ingredient Anastrozole - an active ingredient that inhibits the aromatase enzyme of the non-steroid group. This active ingredient is highly selective and has strong effects, especially in postmenopausal women. Oestradiol is produced by the conversion of Androstenedione to Oestrone by the Aromatase enzyme complex in peripheral tissues, which is then converted to Oestradiol.Thanks to the reduction of Oestradiol in the blood, it is effective for breast cancer. The study has a high sensitivity, showing that Arezol - the ingredient in Dilonas at a regular dose of 1mg/day has reduced oestradiol by >80% in postmenopausal women. Anastrozole – the ingredient in Dilonas has no progesterone, androgenic or oestrogenic activity. Therefore, high doses do not affect the secretion of cortisol or aldosterone. Therefore, there is no need to provide additional corticosteroids when using Dilonas. Dilonas is rapidly absorbed and reaches peak plasma concentrations within 2 hours of oral administration. The elimination half-life is slow with a half-life of 40-50 hours.
3. Indications for Dilonas
What does Dilonas do? This drug is indicated for patients with early breast cancer that is estrogen receptor positive.
The efficacy of Dilonas in this population was based on an analysis of relapse-free survival in subjects who received Dilonas for a median of 31 months.
In addition, Dilonas is also indicated for subjects with advanced breast cancer after menopause. Subjects with breast cancer have estrogen receptors (-). Although efficacy has not been demonstrated except in patients who have responded positively to previous clinical use of Tamoxifen.
4. Dosage - How to take Dilonas
Dilonas used orally with boiled water to cool, do not use with carbonated water / alcohol / other stimulants, ... Dosage, Dilonas drug as recommended by the manufacturer is 1 tablet / day for adults including the elderly. Dilonas is not intended for use in children.
In special groups such as liver failure, mild and moderate renal impairment, there is no indication to adjust the dose of Dilonas.
5. Contraindications to the drug Dilonas
Dilonas drug is not used for the following subjects:
Pre-menopause; Pregnant; Breastfeeding; Severe kidney failure; Hypersensitivity or allergy to ingredients and excipients contained in Dilonas; Do not share Dilonas with Oestrogen, Tamoxifen; To ensure safety when using Dilonas, do not use drugs for contraindicated subjects.
6. Dilonas drug interactions
Dilonas has manufacturer warnings about drug interactions. Accordingly, do not share Dilonas with drugs:
Oestrogen; Tamoxifen; Inform your doctor/pharmacist about all the medicines you are taking and taking for a long time before taking Dilonas.
7. Dilonas . drug side effects
When taking Dilonas, there may be side effects including:
Hot flashes; Attenuate; Joint pain/stiffness; Vaginal dryness ; Hair loss; Rash; Nausea; Vomit; Diarrhea; Headache; Vaginal bleeding; Anorexia; Erythema; Steven-Johnson syndrome; Angioedema; Medal; Anaphylaxis; ... Inform your doctor of any clinical signs of side effects when taking Dilonas to be managed.
8. Warnings and Precautions for Dilonas
Some safety warnings and cautions given by the manufacturer when taking Dilonas are as follows:
Do not use in children; Determine menopausal status by testing if endocrinology is suspected; There are no data in patients with severe renal or hepatic impairment, so caution should be exercised if Dilonas is used; Osteoporosis or suspected osteoporosis should be checked before and periodically when taking Dilonas; Follow the principle of heeding warnings and cautions when using Dilonas to improve effectiveness and safety.
What is Dilonas drug? Dilonas is a drug used to treat postmenopausal breast cancer. Dilonas is used only by prescription and must be monitored while taking. The interactions and side effects when taking Dilonas are quite complicated, you need to be careful.
