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Demozidim drug containing the active ingredient Ceftazidim is indicated in the treatment of bacterial infections such as inflammatory urinary tract infections, pneumonia, osteoarthritis, vaginitis... Let's learn about its uses and notes when using it. Demozidim drug through the article below.
1. Uses of the drug Demozidim
Demozidim contains the active ingredient Ceftazidim - an antibiotic belonging to the 3rd generation Cephalosporin group. Ceftazidim kills pathogenic bacteria through inhibition of bacterial cell wall synthesis, the drug is stable to most beta-lactamase secretions. produced by bacteria.
Demozidim drug is prepared in the form of powder for injection with the content of Demozidim 1g indicated in the following diseases:
Infections of the upper and lower respiratory tract; Skin and soft tissue infections; Urinary tract infections with or without complications; Bone and joint infections; Gynecological infections; Abdominal infections; Central nervous system infections (including meningitis).
2. Dosage of Demozidim
Demozidin is administered by intramuscular or intravenous injection. Therefore, the manipulation of drug use is performed by medical staff. Demozidin dose is prescribed by the treating doctor based on the medical condition. Some recommendations on dosage of Demozidin are as follows:
Adults:
Intramuscular or intravenous injection 1g/time every 8 hours or 2g/time every 12 hours; Patients with liver failure do not need to adjust the dose; Patients with renal insufficiency need to adjust the dose of Demozidim as follows: Creatinine clearance from 31 to 50ml/min administered at a dose of 1g/time every 12 hours. For patients with creatinine clearance between 16-30ml/min, the dose is 1g/time every 24 hours. For patients with creatinine clearance from 6-15ml/min, dose 500mg/time every 24 hours. For patients with creatinine clearance less than 5ml/min, the dose is 500mg/time every 48 hours. Children:
Newborns from 0 to 4 weeks of age: The recommended dose is 30mg/kg IV every 12 hours; Neonates from 1 month to 12 months: The recommended dose is 30-50mg/kg intravenously every 8 hours (maximum dose should not exceed 6g/day). Elderly: The recommended dose is not more than 3g/day (especially in patients over 70 years old).
3. Demozidim side effects
Demozidim medicine can cause some common side effects such as swelling and pain at the injection site, itching rash, hypersensitivity, vomiting, nausea, diarrhea, abdominal pain.
4. Notes when using Demozidim
Contraindicated to use Demozidin in patients with hypersensitivity to Ceftazidim, Cephalosporin antibiotics or hypersensitivity to any component of Demozidim.
Use caution when using Demozidin in patients with a history of gastrointestinal diseases, especially dysentery. Long-term treatment with Demozidin can lead to pseudoconjunctivitis.
For patients with renal failure, the dose should be reduced according to the patient's condition. High serum concentrations of Ceftazidin may cause geriatrics, convulsions, loss of balance or neuromuscular excitability.
The drug may reduce Prothrombin activity in patients with liver failure, renal failure or malnutrition.
For pregnant women: Ceftazidime has been shown to be safe in pregnant women. However, to ensure safety and effectiveness, the drug should only be used in pregnant women when absolutely necessary.
For women who are breastfeeding: Demozidin is excreted in breast milk, so it should only be used by lactating women when absolutely necessary.
Store Demozidin at room temperature, away from sunlight and high humidity.
5. Demozidim drug interactions
Co-administration of Ceftazidim with aminoglycoside antibiotics, loop diuretics (eg furosemide...) may increase nephrotoxicity.
Ceftazidime and Chloramphenicol antagonize each other, so the combination of these two antibiotics should be avoided.
Sodium bicarbonate solution in particular and solvents with pH above 7.5 in general reduce the effect of Ceftazidime.
Simultaneous use of Demozidin and Vancomycin reduces the effect of both because of the formation of complexes causing precipitation.
Between times of using Demozidin, it is necessary to carefully wash the catheter and syringe with physiological saline (Sodium Chloride 0.9%).
Above is important information about Demozidim drug, hopefully with the above sharing will help the drug treatment and disease treatment process be more effective and safer.
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