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Cortrosyn is a man-made hormone commonly used to aid in the diagnosis of pituitary and adrenal gland disorders. So what is the use of Cortrosyn and how to use it, learn through the article below.1. What is Cortrosyn?
Cortrosyn - adrenocorticotropic hormone (ACTH). This is a hormone normally produced by the pituitary gland. ACTH stimulates the adrenal glands to release the hormones cortisol and adrenaline, which play an important role in reducing stress and supporting the circulatory, endocrine, nervous or immune systems. Plasma cortisol concentrations usually peak between 45 and 60 minutes after Cortrosy injection. However, the 30-minute plasma cortisol level does not change throughout the day, so the drug should only be used once a day.
2. Indications of the drug Cortrosyn
Cortrosyn is indicated in the following pathologies:
Used as a reagent to assist in the diagnosis of adrenal dysfunction such as in Addison's disease, in the diagnosis of patients with adrenocortical insufficiency. Check pituitary function in hypopituitarism or Cushing's syndrome.
3. Contraindications of the drug Cortrosyn
Cortrosyn must not be used in the following casesAllergy to cortrosyn or any other ingredient of the drug. Allergic reaction in any prior ACTH hormone stimulation test. Note when taking Cortrosyn
Take blood to check pituitary and adrenal gland function 30 - 60 minutes before taking the drug. There is no evidence to support the safety of the drug in children under 2 years of age.
4. Drug interactions
Vitamins and herbs can affect the effect of drugs when taken together. Therefore, it is necessary to inform the doctor of all previously used medicines. Spironolactone diuretics can cause electrolyte disturbances when used in combination with Cortrosy.
5. Dosage and usage
How to use:
Cortrosyn is prepared as a powder for intravenous or intramuscular injection, containing cortrosyn 0.25mg and 10mg mannitol mixed with 1ml of 0.9% NaCl. Venous blood collection 30 minutes before drug administration and second time after 30 minutes of drug administration Inject a single dose. Dosage:
Adults use a dose of 0.25mg - 0.75mg intravenously. Children over 2 years old intravenously 0.125mg / time. Can be infused intravenously in 2 - 5 ml of saline over 2 minutes. Or take 0.25mg added to a glucose or saline solution and infused at a rate of about 40 micrograms per hour over a 6-hour period. Normal plasma cortisol levels should be greater than 5 micrograms per 100 mL. Cortisol levels after 30 minutes should rise by at least 7 micrograms per 100mL above baseline. A normal 30-minute cortisol level should rise in excess of 18 micrograms per 100mL.
6. Side effects of the drug Cortrosyn
Some unwanted effects may occur when taking CortrosynAllergic reactions, hives, rash, difficulty breathing, swelling of the face, lips, tongue, throat, difficulty swallowing. Fast or slow heart rhythm disturbances. Hypertension . Faint. Swollen hands and feet. Change vision. Causing mutagenicity, carcinogenicity and reduced fertility in laboratory animals. In summary, Cortrosy is a drug used to diagnose hormone deficiencies in the pituitary and adrenal glands. Medicines must be prescribed and administered by a specialist.
