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Clopalvix plus has the main active ingredient containing Clopidogrel + Acetylsalicylic acid (75mg + 75mg) and is made in the form of film-coated tablets. The drug is effective in helping to reduce the events caused by atherosclerosis.
1. What is Clopalvix plus?
Drug group: Clopalvix plus belongs to the group of drugs for the treatment of cardiovascular diseases. Dosage form: The drug comes in the form of film-coated tablets. Packing: Box of 1 blister x 10 tablets; Medicine box includes 3 blisters x 10 tablets. Active ingredients: Aspirin with the content of 75mg and Clopidogrel (as Clopidogrel bisulfate) with the content of 75mg.
2. What disease does Clopalvix plus treat?
Primary prevention of disorders caused by thromboembolism such as myocardial infarction, stroke and peripheral artery disease. Control and secondary prevention in atherosclerotic patients with recent stroke, recent myocardial infarction, or established peripheral artery disease.
3. Usage and dosage of Clopalvix plus
Clopalvix plus is not affected by food, so you can take it with or without food. People with a history of atherosclerosis: the therapeutic dose is 1 tablet (75mg) per day. Prophylactic dose to prevent thromboembolic disorders such as myocardial infarction, peripheral artery disease and stroke is: 1 tablet (75mg)/day. Acute coronary syndrome (unstable angina/non-Q-wave myocardial infarction): The initial dose is 300 mg as a single dose, and the maintenance dose is 75 mg daily. No dose adjustment is required in the elderly or in patients with renal impairment.
4. In case of overdose or forgetting dose of Clopalvix plus
In case of missed dose and how to handle it
Usually drugs including Clopalvix plus can be taken within 1-2 hours compared to prescribed in the prescription. Unless there are strict regulations on the time of use, the medicine can be taken a few hours after forgetting. However, if the time to remember to use the drug is too far from the time it should be taken, it should not be taken to make up, which can be dangerous for the body. You need to follow it properly or consult your treating doctor before making a decision. In case of drug overdose and treatment
In case of overdose of the active ingredient Clopidogrel leads to prolongation of bleeding time and then complications of bleeding. Signs and symptoms of acute toxicity are vomiting, fatigue, dyspnea, and gastrointestinal bleeding
5. Undesirable effects of the drug Clopalvix plus
Active ingredient Clopidogrel is generally well tolerated. However, when using the drug during treatment, you also have a few unwanted effects as follows:
Common unwanted effects: Gastrointestinal disorders including diarrhea, abdominal pain, difficulty diarrhea and nausea and skin irritation including erythema accompanied by rash. Uncommon side effects such as chest pain or nosebleeds. Rare adverse effects such as: Gastrointestinal bleeding, gastric ulceration, severe neutropenia or agranulocytosis, thrombocytopenia, thrombocytopenic purpura , aplastic anemia, kidney disease such as nephritic syndrome, loss of taste or acute arthritis. Other possible side effects include: thrombocytopenia, intracranial hemorrhage or ocular hemorrhage.
6. Clopalvix plus drug interactions
Aspirin: There may be a pharmacodynamic interaction between Clopidogrel and Aspirin leading to an increased risk of bleeding. Therefore, you need to consult your doctor when you need to take these two drugs together. However, Clopalvix plus and Aspirin can be combined for up to 1 year. Heparin: A pharmacodynamic interaction between the active ingredients Clopidogrel and Heparin may lead to an increased risk of bleeding. Therefore, the simultaneous use of these two drugs should be borne in mind. Warfarin: May increase the risk of bleeding, so concomitant use of Clopalvix plus and Warfarin should be noted. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): In a study in healthy volunteers receiving naproxen, the concomitant use of naproxen and clopidogrel was associated with an increased risk of potential gastrointestinal bleeding. Therefore, caution should be exercised when clopidogrel is used concomitantly with non-steroidal anti-inflammatory drugs. Drugs Metabolized by the Cytochrome P450 System: At high concentrations in vitro, the active ingredient Clopidogrel inhibits Cytochrome P450 (2C9). Therefore, care should be taken when combining Clopidogrel with these drugs. Other combinations of therapy: Concomitant use of drugs that inhibit the enzyme CYP2C19 activity may reduce the concentration of the active metabolite of Clopidogrel.
7. Some notes when using Clopalvix plus
7.1. Contraindications when using the drug People who are sensitive or hypersensitive to any of the ingredients of the drug. Patients with bleeding disorders such as peptic ulcer or intracranial hemorrhage. People with severe liver failure. 7.2. Cautions and precautions Use with caution in people with bleeding due to trauma, surgery or other medical conditions. In the case of people who are about to have surgery, the use of preparations containing the active ingredient Clopidogrel must be stopped 5 days before surgery. Clopidogrel should be used with caution in patients with bleeding-prone lesions (such as ulcers). The use of drugs can cause similar injuries in people being treated with products containing clopidogrel. Caution should be exercised in subjects with hepatic impairment who have altered metabolism (poor metabolism due to CYP2C19). 7.3. Use of drugs with special groups For pregnant women: There are no adequate studies on the use of Clopalvix plus in pregnant women. You should only use the drug during pregnancy when clearly needed, when the doctor has weighed the benefits and possible risks. For lactating women: There have been no studies on the excretion of the active ingredient clopidogrel in breast milk. Because many drugs can be excreted in human milk, caution should be exercised when clopidogrel is used in nursing women. For the ability to drive or use machines: Clopidogrel has no influence on the ability to drive and use machines. Clopalvix plus has the main active ingredient, Clopidogrel + Acetylsalicylic acid (75mg + 75mg) and is made in the form of film-coated tablets. The drug is effective in helping to reduce the events caused by atherosclerosis. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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