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Clonixin is a nonsteroidal anti-inflammatory drug (NSAID) structurally similar to Diclofenac. The drug is indicated for the treatment of pain in some pathological symptoms. To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
What is Clonixin?
Clonixin is a nonsteroidal anti-inflammatory drug (NSAID) structurally similar to Diclofenac with vasodilator and analgesic effects. The drug is prepared in the form of softgels or film-coated tablets with the strength of 125mg and 250mg.
Clonixin medicine is indicated in the treatment of headaches, muscle aches, joints, teeth, ears, menstrual pain, after trauma, after surgery, gynecology. The adverse effects were nausea, dizziness and somnolence, which were mild and transient. In rare cases of high doses, patients may develop dry mouth or constipation.
Absorption of Clonixin: Clonixin is rapidly absorbed after oral administration. Peak plasma concentrations are achieved 1 hour after dosing. The half-life of clonixin in human plasma is about 1.75 + 0.10 hours. Concentrations in milk are about 7 to 10% of plasma concentrations. Distribution of the drug Clonixin: Clonixin is widely distributed in many body fluids and tissues. The rate of binding to plasma proteins ranges from 96 to 98%. The main clonixin compound is found in the blood about 6 hours after taking the drug. The volume of distribution is 0.112 L/kg body weight. Drug metabolism Clonixin: The drug is metabolized to 5 -OH Clonixin and 4 -OH Clonixin. Elimination of the drug Clonixin: Within 24 hours of taking the drug, an oral dose of 500mg is excreted in the urine about 62%, mainly in the form of metabolites 4-OH Clonixin and 5-OH Clonixin. Less than 1% of the remaining clonixin is excreted in the feces. After 120 hours of dosing, the amount of drug excreted in urine and feces is about 86%.
2. What is the use of Clonixin?
2.1. Mechanism of action of Clonixin The mechanism of Clonixin does not appear to be studied at the molecular level. At high concentrations, clonixin is thought to act similarly to other NSAIDs by acting primarily on the enzyme that catalyzes the production of prostaglandins responsible for inflammation (cyclooxygenase-2 or COX-2), with less impact. On the enzyme that catalyzes the synthesis of prostaglandins in the gastric and renal mucosa (cyclooxygenase-1 or COX-1), prostaglandins have a protective role at this site.
Clonixin is a non-steroidal agent, it is an anilino-nicotinic acid derivative and is structurally similar to flufenamic acid. Clonixin is a drug with antipyretic and analgesic activity that causes mild gastrointestinal side effects.
2.2. Indications for use of Clonixin Drugs Clonixin is indicated for the control of pain and spasms of smooth muscle, located in any part of the gastrointestinal tract, genitourinary and liver. Its main signs are:
Gastrointestinal: spastic syndrome of the esophagus, pylorus, bowel or colon and irritable colon. Urinary system: renal colic, ureteral and bladder spasms, cystitis and seminal vesicle inflammation, kidney or ureteral stones. It is also used when one has to perform a specific examination of the urinary tract. Female genital tract: dysmenorrhea, premenstrual tension, tubal spasms, painful adnexal processes and spasticity in the postpartum period. 2.3. Contraindications of the drug Clonixin Patients with allergies and hypersensitivity to any component of Clonixin Pregnant and lactating women should not use because there are no formal studies on this subject. Patient has gastric ulcer, duodenal bulb. Do not use in children under 12 years of age Use with caution in patients with a history of coronary artery disease, peripheral vascular disease, severe hypertension, progressive liver or kidney failure.
2.4. Drug Interactions Concomitant use of anticholinergics should be avoided, because they potentiate the effects of atropine. Concomitant use of clonixin with other anti-inflammatory analgesics, including low-dose aspirin, increases the risk of undesirable effects, especially on the gastrointestinal tract. Concurrent use of clonixin and warfarin may increase the risk of gastrointestinal bleeding. Clonixin acts by causing arteriolar constriction to the glomeruli, which may increase nephrotoxicity as well as reduce the antihypertensive effect of angiotensin II receptor blockers (ARBs) and ACE inhibitors. ). Co-administration of furosemide and thiazides with clonixin also reduces the effect of this class of diuretics. Concomitant use of clonixin with lithium salts can lead to increased plasma concentrations of lithium salts, which can cause serious, life-threatening toxicity. If clonixin and methotrexate are to be used, they should be taken at least 24 hours apart, as clonixin can increase plasma concentrations of methotrexate. 2.5. Side effects of the drug Clonixin With the digestive system: Using Clonixin for a long time can cause side effects on the gastrointestinal tract, especially can cause peptic ulcer, gastric perforation and more serious gastrointestinal bleeding. . In this case, the patient should stop taking the drug and notify your doctor immediately. Other undesirable effects: Occasionally, the drug can cause nausea, vomiting, somnolence, dizziness, headache, sweating, mania.
3. How to use Clonixin
Using clonixin by mouth, should take the drug with filtered water and after meals. The usual adult dose is 1 to 2 tablets at a time, with additional doses possible after 8 hours. The dose used is not the same for all patients and will be adjusted on a case-by-case basis.
A course of treatment can last from 7 to 10 days or maybe longer depending on the medical condition of each person.
4. Notes when using Clonixin
Clonixin only treats symptoms (mainly relieves pain), does not work to solve the root cause of the pain. Before appointing Clonixin in the treatment of chronic diseases, it is necessary to perform clinical tests (liver/kidney function, blood count, urine...) and regularly monitor the patient's condition to keep up with Timely detection of unwanted effects and timely discontinuation of the drug. Using clonixin as monotherapy for pain and inflammation in an infection may cause the infection to spread to other tissues. Therefore, appropriate antibiotics must be used concurrently. Minimize the combination of Clonixin with other anti-inflammatory drugs, unless it is absolutely necessary. As with other systemic NSAIDs (except aspirin), clonixin use may increase the frequency of cardiovascular thrombotic events, including myocardial infarction and stroke, which may lead to to death. This risk increases with increasing dose and length of use. Therefore, before prescribing Clonixin for long-term use, patients must be assessed for the risk of cardiovascular events, as well as regularly monitored during treatment. To minimize this risk, the lowest effective daily dose of clonixin should be used for the shortest possible time.
The drug can cause vomiting, dizziness, drowsiness, headache. Therefore, do not drive or operate machinery while taking this medicine.
Clonixin is a nonsteroidal anti-inflammatory drug (NSAID) structurally similar to Diclofenac. The drug is indicated for the treatment of pain in some pathological symptoms. To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
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