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Capoluck is used in the treatment of megaloblastic anemia, late rectal cancer, and toxicity related to folic acid antagonists. To ensure safety and maximize the effectiveness of treatment, you need to take Capoluck exactly as prescribed by your doctor / pharmacist.1. What is Capoluck?
Capoluck belongs to the group of emergency and antidote drugs, made in the form of an injectable solution, packing specifications: Box of 5 ampoules x 5ml.
The folinic acid component in the form of calcium folinate in Capoluck is an antidote to folic acid antagonists. Calcium folinate is involved as a cofactor for the one-carbon transport reaction in the biosynthesis of purine and pyrimidine of nucleic acids. Impaired thymidylate synthesis in individuals with folic acid deficiency causes defective DNA synthesis and megaloblastic anemia. Because it can be converted to other tetrahydrofolic acid derivatives, folinic acid is a potent antidote. In some cancers, folinic acid penetrates and rescues normal cells from the toxic effects of folic acid antagonists better than tumor cells.
2. What does Capoluck do?
With the above mechanism, Capoluck drug is effective in the treatment of the following conditions:
Prevention and treatment of toxicity related to folic acid antagonists; Capoluck in combination with high doses of methotrexate in chemotherapy; Treatment of megaloblastic anemia; In combination with 5-fluorouracil for the treatment of late rectal cancer.
3. Dosage, how to use Capoluck
Reference dose is as follows:
Neutralize toxic effects caused by high dose Methotrexate: Capoluck 15mg/m2 of body skin/6 hours for 72 hours. Can be used for 5-7 days. Then reduce the dose and switch to oral. Calciumfolinate should be used several hours after a high dose methotrexate infusion; Treatment of megaloblastic anemia caused by folic acid deficiency: Dose 5-15mg/day; Calcium folinate combination in the treatment of rectal cancer: IV 200mg/m2 of body skin/24 hours. The above dosage of Capoluck is for reference only. The specific dose of Capoluck will depend on your condition and disease progression. To get the right dose of Capoluck, patients need to consult with their doctor or pharmacist.
How to use Capoluck:
Separate injection of Calcium folinate and 5-fluorouracil to avoid precipitation; Dose > 10mg/m2: Need to mix Capoluck with sterile water and use immediately; Do not IV > 160mg/min (16mL of 10mg/mL solution or 8mL of 20mg/mL solution per minute).
4. Contraindications to the use of Capoluck
Capoluck is contraindicated in the following cases:
Hypersensitivity to any component of Capoluck; Pernicious anemia; Megaloblastic anemia due to vitamin B12 deficiency. There is tumor growth; Elderly; Debilitated patient.
5. Interactions with other drugs
Possible interactions if Capoluck is used concurrently with the following drugs:
5-fluorouracil; Loss of antiepileptic effect of drugs Phenytoin , Phenobarbital , Primidon and increased number of seizures in susceptible pediatric patients; Reduces the effect of methotrexate injected into the spinal canal. To avoid unwanted interactions, patients should inform their doctor/pharmacist of all medications and dietary supplements they are using.
6. Side effects of the drug Capoluck
Capoluck can increase the toxicity of 5-fluorouracil and cause the following symptoms:
Stomatitis ; Pharyngitis - esophagus; Diarrhea; Anorexia; Nausea/vomiting; Hair loss ; Dermatitis; Decrease in white blood cell count. During the course of treatment, if there are any unusual symptoms suspected of using Capoluck, the patient should notify the treating doctor for timely treatment.
7. Precautions while using Capoluck
Capoluck should be used with caution in the following cases:
People with undiagnosed anemia; Reduce the dose of 5-fluorouracil in people with moderate - severe hematological or gastrointestinal toxicity; The article has provided information about what Capoluck is, dosage and precautions for use. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Capoluck exactly as directed by your doctor.
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