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Capecine 500 is made in the form of tablets, with the main ingredient being Capecitabine. The drug is used in the treatment of stomach cancer, breast cancer, and colon cancer.
1. What is Capecine 500?
1 Capecine 500 tablet has the main ingredient 500mg of Capecitabine and other excipients. Capecitabine is an active ingredient whose main use is to treat colorectal cancer that has metastasized or stage 3 (after surgery). The drug can be used alone in monotherapy regimens for breast cancer, stomach cancer or in combination with other drugs to improve treatment effectiveness. In addition, Capecitabine is also used to treat breast cancer for patients who have not responded to treatment with Anthracycline or Taxane group drugs. In addition, a few cases of patients with advanced breast cancer who do not respond to chemotherapy measures can combine Capecine 500 with Docetaxel. At the same time, Capecine 500 can be combined with platinum agents to treat advanced gastric cancer.
Indications to use Capecine 500
Treatment of breast cancer; Treatment of stomach cancer; Treatment of colon cancer. Contraindications to using Capecine 500
People who are allergic to capecitabine, fluorouracil (Adrucil) or any of its ingredients; Pregnant women; Patients with liver failure, kidney failure, people with severe leukopenia or thrombocytopenia; Patients with galactose intolerance (because the composition of the drug contains galactose).
2. How to use and dose Capecine 500
Usage: Orally. To avoid gastrointestinal irritation, the patient should take the drug with water within 30 minutes after eating.
Dosage: Depending on the condition and severity of the disease, the dose of the drug can be changed. The reference dose is as follows:
Single treatment:
Colorectal cancer, breast cancer: Use dose 1250mg/m2/time x 2 times/day for 14 consecutive days; Then 7 days off the drug. Combination therapy:
Early stage breast cancer: Start treatment with a dose of 1250mg/m2/time x 2 times/day for 14 days. In combination with Docetaxel. Then 7 days off the drug; Stomach cancer, colorectal cancer: Use a dose of 800-1000mg/m2/time x 2 times/day x 14 days. Then 7 days off the drug. Or can use dose 625mg/m2/time x 2 times/day if continuous treatment.
3. Side effects of the drug Capecine 500
When using Capecine 500, patients may experience some side effects such as:
Nausea, vomiting, constipation, loss of appetite, fatigue, headache, dizziness, weakness, trouble sleeping or taste changes. Symptoms of nausea and vomiting can be severe. In some cases, doctors may prescribe medications to prevent or relieve nausea and vomiting. In addition, the patient should eat small meals, not eat before treatment and limit activities to relieve these symptoms; Diarrhea is also a common side effect of Capecine 500. Patients should drink plenty of fluids and may take additional medications prescribed by their doctor (such as loperamide) to reduce diarrhea. If diarrhea and vomiting do not stop, the patient may become severely dehydrated and when experiencing symptoms of dehydration such as dry mouth, dizziness, decreased urination, etc., the patient should immediately notify the doctor. ; Temporary hair loss may occur with Capecine 500. Usually, hair grows back after treatment ends. In addition, the patient may also have some temporary changes in the fingernails and toenails; Serious side effects: Severe nausea, vomiting (vomiting twice a day, unable to keep food in the stomach), skin redness, swelling, pain in the mouth or tongue,... When experiencing reactions this serious, the patient should immediately notify the doctor; Capecine 500 may affect fertility in men and women of reproductive age; Capecine 500 may decrease your ability to fight infections, increasing your risk of serious infections. Patients should tell their doctor if there are signs of infection such as sore throat, chills, cough, fever,...; Patients should tell their doctor right away if they have any serious side effects such as: Bruising on the skin, easy bleeding, mood swings (depression), vision changes, ankle swelling, problems with kidneys (change in the amount of urine), dark urine, yellow eyes, jaundice,...; Rarely, very serious allergic reactions to Capecine 500 medicine such as: rash, peeling skin, itching or swelling of the face, tongue, throat, difficulty breathing, severe dizziness,... With Capecine 500, patients should immediately contact their doctor to receive timely advice and support.
4. Be careful when using Capecine 500
Some notes for patients to remember before and while taking Capecine 500:
Capecine 500 can cause many side effects, so it should only be used when prescribed by a doctor; For patients with low platelets and white blood cells, the initial dose of drug therapy should be low and follow the cycle, stopping treatment when necessary; Be especially careful when using Capecine 500 in people who are allergic to the drug's ingredients, the elderly, children, people with liver - kidney disease; Patients need to be closely monitored health during the use of Capecine 500; Capecine 500 has the potential to affect vision, so it should be used with caution when driving or operating machinery; To ensure the safe use of Capecine 500, patients should inform their doctor if they have problems such as bleeding or clotting disorders, a history of coronary artery disease, or are taking blood thinners (warfarin, coumadin). , jantoven); Capecine 500 should be used with caution in pregnant women and nursing mothers.
5. Capecine 500 . drug interactions
Some drug interactions of Capecine 500 include:
Coumarin anticoagulants: Side effects occur within a few days and last up to several months after treatment with Capecitabine. Patients receiving coumarin-derivative anticoagulants with capecitabine should be carefully monitored for coagulation parameters (PT or INR) and the anticoagulant dose adjusted accordingly; Cytochrome P450 2C9 Substances: Careful monitoring is recommended when capecitabine is co-administered with these agents; Phenytoin: When capecitabine and phenytoin are co-administered, plasma concentrations of phenytoin are increased. Careful monitoring is required in patients when phenytoin is co-administered with capecitabine; Antacids: There is a drug interaction between Capecitabine with aluminum hydroxide and antacids containing magnesium hydroxide; Sorivudine and Similar Drugs: Capecitabine should not be used concomitantly with sorivudine or chemically related analogues (such as brivudine). It is necessary to wait at least 4 weeks after termination of sorivudine or brivudine-like drugs before starting capecitabine therapy; Leucovorin (folinic acid): Leucovorin has an effect on the pharmacodynamics of Capecitabine and may increase the toxicity of Capecitabine. Before using Capecine 500, the patient should inform the doctor about the drugs/pharmaceuticals he is currently or recently using as well as the diseases he has/are suffering to be adjusted accordingly, avoiding the risk of similarity. drug effect. In the process of taking the drug, patients should also regularly check their health and closely monitor the biochemical indicators of the body.
When prescribed to use Capecine 500, patients should coordinate with all instructions of the doctor, avoiding the case of missed dose or drug overdose because it can cause many dangerous consequences. If you have any questions, you should contact your doctor directly to get the fastest advice.
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