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Capebina is a drug used in the treatment of cancer. The following article will inform you about the uses and indications of Capebina.
1. What is Capebina?
What is Capebina? Capebina is an anti-cancer and immunosuppressive drug manufactured by Laboratorio Eczance Pharma S.A - Argentina. Capebina medicine contains the ingredient Capecitabine 500mg, which is made in the form of tablets.
2. Uses of the drug Capebina
Capecitabine has a selective cytotoxic effect on tumor cells. In vitro Capecitabine is not cytotoxic.
But in vivo, capecitabine is continuously converted to the cytotoxic radical 5-FU, which is further metabolized. The formation of 5-FU in tumors is optimally catalyzed by thymidine phosphorylase (dThdPase) - a tumor-associated angiogenic factor, thereby reducing the extent of 5-FU on healthy tissue. . Capecitabine metabolites damage cells by two mechanisms: First, FdUMP and folate cofactor N5-10-methylenetetrahydrofolate bind to thymidylate synthase (TS) to form a complex consisting of three cofactors. chemotherapy. Inhibits thymidylate formation from uracil. Thymidylate is an essential precursor of thymidine triphosphate, which is essential for DNA synthesis, so a deficiency of this compound can inhibit cell division. Second, nuclear transcription enzymes may mistakenly incorporate FUTP instead of uridine triphosphate (UTP) during RNA synthesis. This can affect RNA and protein synthesis. Capebina is indicated in the following cases:
Capebina is used alone or in combination with other cancer treatments. Has the effect of slowing down and stopping the growth of cancer cells, reducing tumor size. Breast cancer: Capecitabine is used in combination with docetaxel in the treatment of patients with locally advanced or metastatic breast cancer following failure of chemotherapy. Colorectal cancer: Capecitabine is indicated for the adjuvant treatment of patients with colon cancer after surgery or patients with metastatic colorectal cancer. Stomach cancer: Capecitabine in combination with a platinum compound is indicated for the first-line treatment of patients with gastric cancer.
3. Dosage and how to take Capebina
Single treatment: Colorectal cancer, breast cancer: use 1250mg/m2, 2 times/day for 14 days, then rest for 7 days.
Combination treatment:
Breast cancer: Initial dose 1250 mg/m2, 2 times/day for 2 weeks, in combination with docetaxel, then 7 days off. Stomach and colorectal cancer: Dose 800-1000 mg/m2/time x 2 times/day x 2 weeks, then rest for 7 days or 625 mg/m2/time x 2 times/day for continuous treatment. How to use Capebina drug: Should take the drug with water within 30 minutes after eating.
It should be noted: For Capebina drugs, it is necessary to use the prescribed dose, not arbitrarily adjust.
If Capebina overdose, what should the patient do? When taking an overdose of Capebina, you should stop taking it immediately and tell your doctor or pharmacist if you have any unusual symptoms. In case of emergency symptoms, the patient should be taken to a medical facility for timely treatment.
If a dose of Capebina is missed, what should the patient do? Usually, if the time of remembering is about 1-2 hours after the indicated time, the patient should take it immediately. If the time of remembering is far from the dosing schedule, do not take the supplement, which can be dangerous for the body.
4. Contraindications when using Capebina
Contraindicated when using Capebina drug in the following cases:
People with a history of allergy to capecitabine or fluorouracil. People with severe kidney disease or a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency. Do not use Capebina in pregnant women, because of the risk of harm to the unborn baby.
5. Capebina drug side effects
Side effects of Capebina drug may occur during use as follows:
Some symptoms may occur when using Capebina drug such as: nausea, vomiting, loss of appetite, constipation, fatigue , weak strength, trouble sleeping, dizziness, headache, change in taste. Nausea and vomiting can be severe and require the use of antiemetics. Diarrhea is also a common symptom when using Capebina, if this condition persists, it can lead to dehydration. Temporary nail changes may occur. Usually the treating physician prescribes Capebina, because they have judged that the benefits outweigh the risk of side effects for the patient. Therefore, it is necessary to carefully monitor and notify the doctor immediately to take measures to minimize the side effects. Patients should stop taking the drug when serious side effects occur: vomiting twice a day, inability to eat or keep food/liquid in the stomach, skin redness/swelling/pain in the mouth or on the tongue. For men and women of childbearing age, Capebina may affect your ability to have children. Capebina may make the body less able to fight infections. As a result, patients who use this drug often develop a more serious (rarely fatal) infection. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough, etc.). The following serious reactions should be reported to a doctor immediately for advice: skin bruising/bleeding easily, mental/mood changes (such as depression), swelling of the ankles or feet, changes vision changes, signs of kidney problems (such as change in the amount of urine), yellowing of the eyes, jaundice, dark urine. Allergic reactions are rare, however tell your doctor if the following symptoms occur: rash/skin peeling, itching or swelling (especially of the face/tongue/throat), severe dizziness , shortness of breath.
6. Precautions and notes when taking Capebina
Capebina can cause a lot of unwanted effects, so patients should only use it when prescribed by a doctor. With caution to people who are allergic to any ingredient of the drug, the elderly, pregnant women, lactating women, children under 15 years old, people with liver failure, kidney failure, people with myasthenia gravis, peptic ulcer, hepatic coma. Store Capebina at room temperature, in a dry place, away from direct sunlight or high temperature.
Capebina is an anti-cancer and immunosuppressive drug manufactured by Laboratorio Eczance Pharma S.A - Argentina. Capebina medicine contains the ingredient Capecitabine 500mg, which is made in the form of tablets. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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