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Camxicam contains the ingredient Piroxicam, which is a non-steroidal anti-inflammatory drug administered intramuscularly, indicated in the treatment of bone and joint diseases such as osteoarthritis, ankylosing spondylitis, osteoarthritis,...
1. What is Camxicam?
Camxicam drug is prepared in the form of an injection solution, containing the active ingredient Piroxicam with a concentration of 20mg/1ml.
1.1. Pharmacodynamics of Camxicam (Piroxicam) Camxicam drug contains Piroxicam ingredient, which has analgesic and anti-inflammatory effects. Piroxicam is an anti-inflammatory drug that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). Piroxicam has anti-inflammatory effects of various etiologies.
In laboratory animals, Piroxicam inhibited edema, erythema, tissue hyperplasia, analgesia and antipyretic. Piroxicam inhibits neutrophil aggregation, preventing the migration of polymorphonuclear leukocytes and monocytes to areas of inflammation. Piroxicam inhibits enzymes released by lysosomes from stimulated leukocytes. Piroxicam inhibits the production of superoxide anion by neutrophils. Piroxicam has been shown to reduce systemic and synovial rheumatoid factor (RF) production in patients with seropositive rheumatoid arthritis. 1.2. Pharmacokinetics of Camxicam (Piroxicam) About absorption: Piroxicam is well absorbed after dosing, even when administered orally. When taking Piroxicam orally, food may slightly decrease the rate of drug absorption but does not affect the extent of drug absorption. Distribution: The percentage of Piroxicam bound to plasma proteins is up to 99%. Metabolism: Piroxicam is extensively metabolised with the major route of metabolism being hydroxylation of the pyridyl nucleus and conjugation with glucuronic acid. Elimination: 5% of the daily dose of Piroxicam is excreted unchanged in the urine and feces.
2. Indications of the drug Camxicam
Camxicam is mainly indicated for pain relief, anti-inflammatory in osteoarthritis or can be used to relieve pain in some other cases. Indications for treatment of the drug include:
Osteoarthritis. Rheumatoid arthritis. Ankylosing spondylitis . Osteoarthritis. Acute Gout . Acute musculoskeletal disease. Musculoskeletal pain due to acute trauma. Pain after surgical intervention. Menstrual system.
3. Dosage and how to use Camxicam
Camxicam is prepared in the form of a solution for injection. Each ampoule of Camxicam contains 1ml of solution with 20mg of Piroxicam, to be administered intramuscularly. The technique of intramuscular injection of Camxicam is similar to that of other intramuscular drugs, it is necessary to ensure sterility during the injection process and pay attention not to mistakenly inject into the blood vessels.
3.1. Dosage of Camxicam according to the level of pain relief Camxicam is indicated for pain relief, especially for bone and joint diseases, with the following doses:
For severe pain: Camxicam can be injected intramuscularly at a dose of 40mg/day. Camxicam 20mg x 2 ampoules/day) for the first 2 days, then reassess the pain level and may reduce the dose of Piroxicam to 20mg/day if the patient's pain is relieved. For moderate pain: Camxicam can be used at a dose of 20mg/day, intramuscularly for 1-3 days, then consider switching to oral Piroxicam. 3.2. Dosage of Camxicam according to the pathology Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis: The usual dose of Piroxicam is 20mg per day. Acute Gout: Usually begins with a dose of Piroxicam 40mg/day, which can be used only once a day or divided into 2 times/day. Piroxicam treatment in acute gout is usually about 4-6 days, not Piroxicam treatment for patients with persistent chronic gout. Acute Musculoskeletal Disorders: A dose of 40 mg Piroxicam daily may be initiated for the first 2 days and a dose reduction to 20 mg/day may be considered. Pain after surgery, pain due to trauma: The starting dose of Piroxicam is 20mg/day. In the case of a rapid effect, it is possible to start with Piroxicam 40mg/day for the first 2 days of treatment, then reduce the dose to 20mg/day. Primary Dysmenorrhea: Start treatment with Piroxicam as soon as symptoms appear. The initial dose of Piroxicam can be up to 40mg/day for the first 2 days, if necessary, maintenance therapy can be continued for another 1-3 days with a dose of 20mg/day.
4. Undesirable effects of Camxicam
Side effects on the gastrointestinal tract: Camxicam intramuscular injection can cause gastrointestinal ulcers with uncomfortable symptoms, epigastric pain, ... more severe can lead to ulcers, stomach perforation, bleeding digestive blood. In addition, patients taking Camxicam may experience other side effects on the gastrointestinal tract such as anorexia, nausea, abdominal distension, indigestion, constipation,... Hypersensitivity reactions on the skin: Cases have been recorded. Allergic cases after using Piroxicam with skin manifestations such as: rash, itching, ..., or rarely, peeling nails, hair loss,... Lyell syndrome, Stevens - Johnson syndrome, reactions vesicular-vesicles, bronchospasm, angioedema, etc. may also occur in patients receiving Piroxicam, but are rare. Central Nervous System Side Effects: A number of nervous system side effects have been reported in patients receiving Piroxicam such as dizziness, headache, somnolence, anxiety, depression, hallucinations, confusion, ... however these symptoms are also rare. Effects on Renal Function: An increase in BUN and creatinine has been reported in some patients receiving Piroxicam. Hepatic Effects: Increased transaminase levels have been reported in some Piroxicam-treated patients. Fatal drug-induced hepatitis has been reported, however rare. Effects on Hematology: Some patients receiving Piroxicam have decreased hemoglobin and hematocrit but no obvious gastrointestinal bleeding. Thrombocytopenia has also been reported in some cases. Cardiovascular side effects: As with other nonsteroidal anti-inflammatory drugs, systemic use of Piroxicam increases the risk of cardiovascular thrombosis, which can lead to myocardial infarction, stroke, and life-threatening . This risk is increased with high doses and prolonged use of Piroxicam.
5. Contraindications to taking Camxicam
Contraindicated to use Camxicam for cases of hypersensitivity to Piroxicam or other components of the drug.
Patients with a history of bronchial asthma, angioedema, urticaria, or other allergic or hypersensitivity reactions to aspirin or other nonsteroidal anti-inflammatory drugs should not take Piroxicam, because Piroxicam has potential cross-sensitization in people allergic to aspirin and other non-steroidal anti-inflammatory drugs.
Patients with advanced gastric and duodenal ulcers, patients with gastrointestinal bleeding, or people at high risk of bleeding (such as taking anticoagulants, ...) are also subject to contraindications to using Piroxicam due to the following reasons. The gastrointestinal side effects of this medicine may make peptic ulcers worse.
Other contraindications of Camxicam are:
Children under 14 years old; Pregnant; Breastfeeding women; Cirrhosis, severe liver failure; Severe heart failure; Severe kidney failure; Surgical bypass in coronary artery disease.
6. Precautions while using Piroxicam
Piroxicam should be used with extreme caution in patients with a history of peptic ulcer, gastrointestinal bleeding, liver failure, or renal failure. Patients with a history of cardiovascular disease, bleeding disorders should be cautious when taking Camxicam or other drugs containing Piroxicam. Patients with liver failure, renal failure should be closely monitored liver function, kidney as well as other side effects during the use of Piroxicam. Piroxicam should not be used for a long time to treat chronic gout. Piroxicam can make users sleepy, dizzy, dizzy, ... so if you experience these symptoms while taking the drug, you should not drive or operate machinery. Elderly people, patients who are taking diuretics are also subjects to be careful when using Piroxicam. The basic information about the drug Camxicam in the above article is for reference only. Because Camxicam is a prescription drug, patients should not use it on their own, but need to contact a doctor/pharmacist directly to get an appropriate prescription and ensure safety for health.
