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Blautrim is a drug that works with blood. Let's find out more about what Blautrim is, the uses of Blautrim, the brand name Blautrim, how to use Blautrim,... through the article below.
1. What is Blautrim?
Blautrim belongs to the list of drugs that work with blood, used by prescription. Blautrim is manufactured by the pharmaceutical company Blausiegel Industria e Comercio Ltda - BRAZIL, under registration number VN1 - 678 - 12.
The main ingredient in Blautrim is the active ingredient Filgrastim 30MIU (300mcg)/ml. Blautrim is available as a solution for injection. Package of medicine Blautrim box 1 syringe 1ml.
2. Uses of Blautrim
Filgrastim - the main ingredient in the brand-name drug Blautrim is a human granulocyte colony-stimulating factor (G-CSF). This active ingredient in Blautrim is produced by recombinant DNA technology. It has activity similar to that of endogenous human granulocyte-stimulating factors. Blautrim is used to regulate the production and mobilization of neutrophil cells from the bone marrow. In addition, Blautrim stimulates the activation, proliferation and differentiation of neutrophil progenitor cells. In some cases of chronic neutropenia, treatment with the brand-name drug Blautrim also increased the production of eosinophils and basophils. Neutropenia is directly dose dependent with Blautrim.
When treatment with Blautrim is stopped, circulating neutrophils decrease by 50% within 1-2 days. However, they can return to normal in about 1-7 days.
Blautrim is absorbed in a first-order, concentration-independent pharmacokinetic pattern. The mean volumetric Blautrim distribution was 150ml/kg body weight. The mean half-life is 3.5 hours.
3. Indication of Blautrim
Blautrim brand-name drug is indicated to shorten the duration of severe leukopenia and complications in the following subjects:
Using chemotherapy; myelosuppression; In addition, Blautrim is also indicated to increase the number of neutrophils, reduce the frequency and duration of infectious periods in subjects such as:
Congenital with neutropenia; Cyclic leukopenia; Idiopathic leukopenia; Drug-induced leukopenia; ... Blautrim is a prescription drug, so it should only be used as directed.
4. Dosage - how to take Blautrim
Using Blautrim safely needs to be used correctly, at the correct dose of the manufacturer, doctor.
4.1 How to use Blautrim Blautrim is prepared as a solution for injection, so it is administered by subcutaneous injection/infusion. When using, it is necessary to dilute Blautrim with 5% Glucose infusion over 30 minutes.
Filgrastim contained in Blautrim when diluted can be absorbed by glass or plastic materials. However, when diluted at the right ratio, Filgrastim contained in Blautrim will be compatible with glass and some types of plastique including:
PVC; Polyolefin, (1 copolymer of polypropylene and polyethylene); Polypropylene. If the Blautrim component Filgrastim is diluted to a concentration < 1.5 MUI (15 mcg)/ml, human serum albumin should be added to achieve a final concentration of 2 mg/ml.
Example: The volume of the last injection of Blautrim solution is 20ml. The total dose of Blautrim should not exceed 30 MUI (300mcg) so add 0.2ml of 20% HSA human albumin solution.
Note: Never dilute Blautrim to a final concentration of less than 0.2MUI (2mcg)/ml.
4.2 Blautrim Dosage The dose of Blautrim depends on the condition. Specifically:
Chemotherapy for non-myeloid malignancy: The recommended dose of Blautrim is 0.5MUI (5mcg/kg corresponding to 16.6 microlitres of solution for injection). Use Blautrim injection once a day. For a person of 60 kg, it is necessary to use a bottle of Blautrim 30MUI. Chemotherapy and autologous marrow transplantation The starting dose of Blautrim is 1MUI (10mcg/kg/day) by continuous subcutaneous infusion over 24 hours. Or use Blautrim 1MUI (10mcg/kg/day) by continuous intravenous infusion over 30 minutes or over 24 hours. Blautrim should be diluted in 20 ml of 5% glucose infusion. When the lowest leukopenia threshold is reached. At this point, the dose of Blautrim can be adjusted according to the neutrophil response status. Specifically: The neutrophil count > 1.0 x 109/l for 3 consecutive days can reduce the dose of Blautrim to 0.5MUI (5mcg)/kg/day (corresponds to 16.6 microlitre injection solution). /kg). In case of absolute neutrophil count: At >1.0 x 109/l for 3 more consecutive days, stop taking Blautrim. Decrease < 1.0 x 109/l in dosing time, dose of Blautrim can be increased according to the above steps; Filgrastim, the active ingredient in Blautrim, has been shown to be effective and well tolerated when treated as above at doses up to 7.0MUI (70mcg)/kg/day. Chronic severe leukopenia: The starting dose of Blautrim is specific to each condition: Congenital: Blautrim dose 1.2 MUI (12mcg)/day x several times; Spontaneous or cyclical: Blautrim 0.5MUI (5mcg)/kg/day x 1 or more times; Dosage adjustments of Blautrim must first be determined on an individual basis. Ensure to maintain a minimum polymorphonuclear leukocyte count of 1.5 x 109/l. Long-term daily doses of Blautrim are indicated for the purpose of obtaining the required neutrophil count. Adjust dose to a doubling in cases where 2 weeks of Blautrim do not reach the required threshold. Reduce the dose of Blautrim by 1/2 if the granulocyte count rises above 10 x 109/l. Adjust the dose of Blautrim rapidly in subjects with severe infections. If it is certain that the patient can tolerate it, Blautrim may be used in excess of 14.5MUI (145mcg/kg/day). The daily dose of Blautrim should be maintained until the lowest phase of polymorphonuclear leukopenia is passed. The neutrophil count was stable. The course of Blautrim treatment can be up to 2 weeks depending on the dose and cytotoxic chemotherapy regimen. Cytotoxic chemotherapy and autologous marrow transplantation Blautrim dose can be used diluted in 20 - 50 ml of 5% Glucose solution. The starting dose of Blautrim should not be given before 24 hours after chemotherapy.
5. Contraindications Blautrim
Do not use Blautrim for subjects allergic to excipients.
6. Caution Blautrim
Some caution when using Blautrim in subjects with diseases such as:
Patients with myelodysplasia; Acute myeloid leukemia ; Chronic myeloid leukemia unspecified Malignant diseases involving myeloid cells; In addition, when using Blautrim, pay attention to evaluate:
White blood cells; Platelet; Measure red blood cell volume; Monitor bone density... Perform regular tests to make sure it's safe to take brand-name drug Blautrim.
7. Pregnancy and lactation taking Blautrim
There are no studies that affect pregnancy when taking Blautrim. However, to ensure the safe use of Blautrim, it is not recommended for this person; Breastfeeding women should not take Blautrim;
8. Blautrim . Interaction
Some interactions when taking Blautrim are as follows:
24 hours before chemotherapy; Do not dilute with saline solution; ... Also, to be on the safe side, tell your doctor about any medications you're taking when Blautrim is indicated.
9. Blautrim . Side Effects
Some side effects when taking Blautrim include:
Mild/moderate musculoskeletal pain; Mild/moderate dysuria; Hypotension; Increased lactate dehydrogenase; Increased alkaline phosphatase; Increased blood uric acid; Increase Glutamyl transpeptidase; ... In addition, there are also side effects in subjects receiving Blautrim in combination with chemotherapy including:
Nausea; Vomit; Hair loss; Diarrhea ; Tired; Anorexia; Mucositis; Headache ; A cough; Redness of the skin; Chest pain; Muscle weakness; Sore throat; Constipation ; Vascular disorders; ... Inform your doctor about the side effects when taking Blautrim for effective management.
10. Preservation of Blautrim
Blautrim injection solution should be stored at a temperature of 2 - 8 degrees Celsius.
The above information has been provided to you about the drug Blautrim. From there, it helps to use Blautrim brand-name drug safely. If you have other questions about taking Blautrim, ask your doctor/pharmacist.
