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Baraclude belongs to the group of anti-parasitic and anti-viral drugs. This is a specialized antiviral drug used to treat chronic hepatitis B, requiring a doctor's prescription before use.1. What is Baraclude?
Baraclude drug belongs to the group of drugs to treat parasites and viruses, is a drug that inhibits the activity of viruses, especially for patients with chronic hepatitis B. The drug is produced in the form of film-coated tablets, with packing specifications of 10 tablets per blister, three blisters per box.
Baraclude drug is made up of the main active ingredient, Entecavir 0.5 mg and other excipients. The drug has an outer coating made of Titanium dioxide, Hypromellose, ...; Inside the coating is the special drug Entecavir. Entecavir helps inhibit the reverse transcriptase of the enzyme code of the hepatitis B virus, thereby reducing the severity of this disease.
2. What does Baraclude do?
Baraclude has the active ingredient Entecavir. This active ingredient has a similar effect on the body to Guanosin Nucleoside, due to its similar structure. When entering the body, the drug Entecavir is converted into the active form of Triphosphate.
This active form of active substance inhibits the HBV virus reverse transcriptase - an agent that causes hepatitis B. Metabolism of the active ingredient Entecavir Triphosphate inhibits the gamma DNA polymerase of the HBV virus, thereby preventing it. enzyme activity, antiviral.
Baraclude is indicated for use according to drug response, muscle tissue physiology, virology and biochemistry. The use cases of Brraclude drug are listed as follows:
Indications for use in adult patients and children over 16 years of age, chronic hepatitis B virus infection Indicated for use in patients with reported Report of elevated viral DNA replication in the blood Indicated for use in patients with persistently elevated blood aminotransferase levels (including either ALT and AST forms) Indicated for use in patients with biopsies and there is histological evidence of active liver disease. Indications to use Baraclude for patients with decompensated cirrhosis
How to use Baraclude
3.1. How to use Baraclude Baraclude drug is absorbed from the gastrointestinal tract, so patients should use the drug by swallowing the tablet whole with cooled boiled water. The drug may release its effects slowly if ingested with food, so take it on an empty stomach, either at least 2 hours before or 2 hours after a meal.
Hepatitis B patients need regular care and health monitoring during treatment.
The duration of treatment of the drug has not been specifically studied. Drug use for people with chronic hepatitis B is long-term treatment. However, the drug can be stopped when:
There is a change in HBeAg (+): Loss of HBeag, loss of HBV viral DNA, or an anti-HBe inhibitor pattern appears in the blood sample 2 times 3 to 6 apart. month. Stop the drug when it is not effective. Changes in HBeAg levels (-): Use Baraclude until there is a change in HBs blood levels as described above, or stop when it is not effective. 3.2. Dosage of Baraclude The recommended dose of Baraclude is as follows:
For people with decompensated cirrhosis: Use 2 tablets of Baraclude 0.5 mg once daily, taken on an empty stomach.
For adults and children over 16 years of age, with compensated liver: Recommended dose for patients with chronic hepatitis B and not taking nucleosides: Use 1 Baraclude tablet equivalent to 0.5 mg of Entecavir once daily.
Recommended dose for patients with a history of hepatitis B virus infection in the blood while taking lamivudine and/or showing symptoms of lamivudine resistance: Use 2 Baraclude tablets equivalent to 1 mg of Entecavir once daily.
Hemodialysis and hemodialysis cause Entecavir to be eliminated from the body. Take medication after dialysis.
For people with impaired renal function with chronic hepatitis B virus: Decreased creatinine clearance reduces the excretion of Entecavir. Consider dose adjustment in case of patient with creatinine clearance less than 50 mL/min.
For people with impaired liver function with chronic hepatitis B virus: No need to adjust the dose of Baraclude for this subject.
3.3. Treatment of missed dose, overdose Baraclude Overdose:
When a patient takes an overdose of Baraclude, symptoms such as nausea, vomiting, dehydration,...
Treatment:
There is no antidote . Treat symptomatically, such as induce vomiting or infusion of electrolyte-balanced seawater.
3.4. Contraindications Baraclude Do not use Baraclude in patients with hypersensitivity to Entecavir or to any of the other ingredients of Baraclude. Do not use Baraclude in children under 16 years of age. Contraindications to the use of Baraclude in pregnant and lactating women
Precautions while using Baraclude
Side effects of Baraclude When using Baraclude, patients may experience unwanted side effects as follows:
Common side effects include: Nausea, dizziness, drowsiness, indigestion, constipation and increased liver transamines Uncommon side effects include: skin allergies such as rash, itching and hair loss. Rare side effects: anaphylactic reactions Lactic acidosis causing liver enlargement, steatosis and death when used drug Interactions Baraclude Baraclude is used concurrently with drugs that actively compete for elimination with Entecavir in the tubules. The kidneys may increase the concentration of this active substance in the blood. Co-administration of Baraclude with lamivudine, adefovir dipivoxil or tenofovir disoproxil fumarate has not been reported to cause serious drug interactions. Store the medicine Baraclude Store the medicine Baraclude 0.5 mg in a cool, dry place Keep the medicine at room temperature, below 30 degrees Celsius Antiviral therapy for HBV in chronic hepatitis B patients. Using the drug Baraclude requires the permission and advice of a doctor. Hopefully the information provided in the article has helped you understand more about Baraclude as well as its treatment and uses.
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