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Macrolide antibiotics such as Erythromycin or Azithromycin are commonly used in some infectious diseases. One of the products containing Azithromycin is Azitnic 500mg.
1. What is Azitnic 500?
Azitnic 500mg drug has the main active ingredient is Azithromycin dihydrate, equivalent to antibiotic Azithromycin 500mg content. In addition, the ingredients in Azitnic 500mg also include excipients such as Dicalcium phosphate, HPMC K4M, modified starch, croscarmellose sodium, magnesium stearate, sodium lauryl sulfate, HPMC 606, HPMC 615, PEG 6000, titanium dioxide, powder talc. Azithromycin belongs to the group of Macrolide antibiotics with broad-spectrum antibacterial activity and is also known as azalid. Azitnic 500mg drug has a strong bactericidal effect through the mechanism of binding to the ribosomes of pathogenic bacteria, thereby inhibiting their protein biosynthesis.
Azithromycin is effective against some strains of Gram-positive bacteria such as:
Streptococcus, Pneumococcus, Staphylococcus aureus; Corynebacterium diphtheriae; Clostridium perfringens; Peptostreptococcus; Propionibacterium acnes. Some strains of Gram-negative bacteria are susceptible to Azitnic 500, including:
Haemophilus influenzae , parainfluenzae; Moraxella catarrhalis; Acinetobacter, Yersinia; Legionella pneumophila; Bordetella pertussis and parapertussis; Neisseria gonorrhoeae. In addition, Azithromycin is also effective against some other bacteria such as:
Listeria monocytogenes; Mycobacterium avium; Mycoplasma pneumoniae and hominis; Ureaplasma urealyticum; Toxoplasma gondii; Chlamydia trachomatis and Chlamydia pneumoniae; Treponema pallidum; Borrelia burgdorferi. Azitnic 500mg after oral administration will be widely distributed throughout the body with a bioavailability of about 40%. However, food is one of the factors affecting the absorption of this product, namely, it is reduced to about 50%. Following administration, peak plasma concentrations of Azitnic 500 are reached in 2 to 3 hours.
Tissues in the presence of Azitnic 500mg include lungs, tonsils, prostate, granulocytes and macrophages. A small amount of Azithromycin after absorption is methylated in the liver, then excreted in the bile unchanged and partly as metabolites.
2. What are the uses of Azitnic 500mg?
Azitnic 500mg is indicated for use in cases of infections caused by strains of bacteria still sensitive to Azithromycin such as:
Lower respiratory tract infections such as bronchitis, pneumonia; Skin and soft tissue infections; otitis media ; Upper respiratory tract infections, including sinusitis, pharyngitis, tonsillitis; Uncomplicated genital tract infections caused by Chlamydia trachomatis or non-multiresistant gonorrhea (Neisseria gonorrhoeae).
3. Dosage of Azitnic 500mg
Azitnic 500mg is used orally, only once a day, maybe 1 hour before or 2 hours after eating with the following dosage:
Adults:
Upper and lower respiratory tract infections or infections skin and soft tissue: Take 1 tablet of 500mg on the first day, then take a dose of 250mg/day for the next 4 days; Genital tract infections: Use 2 Azitnic 500mg tablets. Children:
First day: Take 10mg/kg body weight/day. From day 2 to day 5 reduce to 5mg/kg body weight/day; Or as directed by your doctor. Contraindications to the use of Azitnic 500mg:
People with a history of hypersensitivity to Azithromycin and other ingredients contained in the drug; Hypersensitivity to any antibiotic of the macrolide group.
4. Some Warnings and Precautions for Azitnic 500
Use caution when using Azitnic 500mg and other macrolide antibiotics because of the risk of serious allergic reactions such as angioedema or severe anaphylaxis (however very rare); Similar to other antibiotics, during the use of Azitnic 500, patients should be monitored for signs of superinfection caused by strains of bacteria that are not sensitive to Azithromycin, including superinfection with fungi; Dosage adjustment of Azitnic 500 is necessary for patients with renal impairment with creatinine clearance less than 40ml/min; Contraindicated to use in patients with liver diseases, because the elimination of the drug is mainly through the liver; There are no data on the use of Azitnic 500mg in pregnant women, and Azithromycin's ability to be excreted in breast milk is unknown. Therefore, Azitnic 500 should only be used in these subjects when absolutely necessary and when no other suitable drug is available.
5. Some unwanted effects of Azitnic 500mg
Similar to antibiotics in the same group of Erythromycin, Azithromycin has a relatively good tolerability and the risk of unwanted effects is also low (only seen in about 13% of users):
Affects hearing ( hearing): Long-term use of Azitnic 500mg at high doses may affect hearing, causing reversible hearing loss in some cases; Some common side effects, including nausea, vomiting, abdominal pain, diarrhea; Less common side effects of Azitnic 500: fatigue, headache, dizziness, drowsiness, skin rash with itching, inflammation of the vagina or cervix...; Rare side effects may include anaphylaxis, angioedema, elevated liver enzymes, and temporary decrease in neutrophil count.
6. Azitnic 500mg . Drug Interactions
Do not use Azitnic 500mg at the same time with ergot derivatives, because of the risk of poisoning; Azithromycin should be taken at least 1 hour before or 2 hours after the time of using gastric antacids; Azitnic 500 combined with Cyclosporin requires monitoring the concentration and adjusting the dose of Cyclosporin appropriately; Concomitant use of Azitnic 500mg with Digoxin will potentially increase the concentration of Digoxin in the blood, so careful monitoring is required. Azitnic 500mg drug has the main active ingredient is Azithromycin dihydrate, equivalent to antibiotic Azithromycin 500mg content. The drug is indicated for the treatment of certain infectious diseases. To ensure effective treatment and avoid side effects, patients need to take drugs according to prescription or consult a doctor, pharmacist for advice.
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