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AustrapharmMesone is made in the form of tablets, with the main ingredient being Methylprednisolone. The drug is used to fight inflammation in some diseases such as rheumatoid arthritis, bronchial asthma, systemic lupus erythematosus,...
1. Uses of the drug AustrapharmMesone
AustrapharmMesone drug has the main ingredient is Methylprednisolone, there are strength forms of 4mg (AustrapharmMesone 4) and 16mg (AustrapharmMesone 16). Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. The drug's mechanism of action is to increase the number of neutrophils, decrease the number of monocytes and eosinophils in the blood. From there, the drug helps reduce inflammation. In addition, this active ingredient also reduces the number of active lymphocytes, causes cell differentiation, and kills sensitive tumor cells. In addition, it also affects the inflammatory response by reducing prostaglandin synthesis by its ability to activate phospholipase A2.
Indications to use AustrapharmMesone:
Treatment of rheumatoid arthritis; Treatment of systemic lupus erythematosus; Treatment of some forms of vasculitis, nodular arteritis, temporal arteritis; Treatment of sarcoidosis; Treatment of bronchial asthma; Treatment of chronic ulcerative colitis; Treatment of severe allergic diseases, including anaphylaxis; Cancer treatment: Breast cancer, lymphoma, acute leukemia, prostate cancer; Treatment of hemolytic anemia in the immune system; Treatment of primary nephrotic syndrome. Contraindications to the use of AustrapharmMesone:
Patients who are sensitive or allergic to the ingredients and active ingredients in the drug; People with skin lesions caused by fungi, viruses; People with severe infections (except tuberculosis and septic shock); People who are taking a live virus vaccine.
2. How to use and dose AustrapharmMesone
Usage: Orally. Patients should take the tablet whole with a full glass of water to reduce the risk of some adverse effects on the stomach. Patients should not arbitrarily break in half or crush the tablet, because it may reduce the quality of the drug and affect the absorption of the drug in the body. Patients should also note that AustrapharmMesone should not be taken with grapefruit juice, because this can increase the concentration of Methylprednisolone in the blood, easily causing an overdose.
Dosage:
Starting dose: Ranges from 4 - 48mg/day depending on the patient. This dose may be maintained or adjusted until a response is obtained. Ideally, the patient should use the lowest effective dose of the drug.
In case it is necessary to use AustrapharmMesone in large doses for a long time, alternate day therapy should be used when the disease process is controlled. Alternate day therapy is to use a single dose, once every 2 days in the morning. The following is a reference dose in the treatment of some diseases:
Treatment of rheumatoid arthritis: Use a dose of 4-6mg/day, acutely use a dose of 16-32mg/day and then gradually reduce the dose; Treatment of acute asthma: Use a dose of 32 - 48mg / day for 5 days, then use a lower dose for 1 week, quickly reduce the dose when the acute asthma is over; Treatment of chronic ulcerative colitis or severe exacerbations: Use dose of 8-24mg/day; Treatment of primary nephrotic syndrome: Use dose 0.8 - 1.6mg/kg/day, used for 6 weeks, gradually reduce dose in 6-8 weeks; Treatment of hemolytic anemia in the immune system: Use dose 64mg/day for at least 6-8 weeks; Treatment of sarcoid: Use a dose of 0.8mg/kg/day, then use a maintenance dose of 8mg/day; Treatment of severe rheumatism: The starting dose is 0.8mg/kg/day, divided into several times a day. After that, the patient takes a single dose and then gradually reduces to the lowest effective dose. Overdose: When using AustrapharmMesone for a long time, patients may experience overdose symptoms including systemic side effects such as: Muscle weakness, Cushing's syndrome, osteoporosis,... Especially, if taking the drug with Too high a dose for a long time can cause adrenal suppression. In this case, the doctor may consider whether to temporarily or completely stop giving the patient AustrapharmMesone.
3. Side effects of the drug AustrapharmMesone
Usually, the side effects of AustrapharmMesone are the most common in patients who take the drug in high doses and for a long time. When using AustrapharmMesone, patients may experience some side effects such as:
Central nervous system: Insomnia, dizziness, nervous excitability, delirium, psychosis; Digestive system: Increased appetite, nausea, indigestion, stomach ulcers, abdominal distension; Skin: Acne growth, hirsutism, skin atrophy, hyperpigmentation; Endocrine and metabolic: Diabetes mellitus, hypokalemia, hyperglycemia, Cushing's syndrome, sodium and water retention; Muscles and bones: Muscle weakness, joint pain, osteoporosis; Eyes: Glaucoma, cataract. When experiencing side effects of AustrapharmMesone, patients should immediately notify their doctor to receive advice on the most appropriate treatment and response.
4. Be careful when using AustrapharmMesone
Some notes patients need to remember before and while taking AustrapharmMesone:
Sudden discontinuation of AustrapharmMesone may cause acute adrenal insufficiency. Therefore, before discontinuing the drug, it is necessary to gradually reduce the dose to avoid this risk; Caution should be taken when using AustrapharmMesone in subjects such as: Osteoporosis patients, patients with mental disorders, people with new blood vessel connections, people with peptic ulcers, heart failure patients, and patients with high blood pressure. , people with diabetes , the elderly or growing children ; Only use AustrapharmMesone in pregnant women and nursing mothers with the permission of a doctor; AustrapharmMesone drugs can cause dizziness, agitation, ... affect the ability of the driver to concentrate, operate machinery. Therefore, this subject needs to be especially careful when taking the drug;
5. AustrapharmMesone drug interactions
Drug interactions can increase side effects or affect the effectiveness of the drug. Therefore, patients should inform the doctor in detail about the drugs they are taking as well as the diseases they are suffering from. Some drug interactions of AustrapharmMesone include:
Interactions with antibiotics such as Clarithromycin, Erythromycin, Rifampicin; Interaction with anticholinesterase drugs such as Neostigmine; Interaction with anticoagulants such as Heparin, Warfarin; Interaction with antifungal drugs such as Ketoconazole, Itraconazole; Interaction with antiepileptic drugs such as Phenobarbital, Phenytoin, Carbamazepine; Concomitant use of AustrapharmMesone with vaccines may suppress the immune response; Concomitant use of AustrapharmMesone with grapefruit juice may increase the toxicity of Methylprednisolone. When prescribed to use AustrapharmMesone, patients should strictly follow the doctor's instructions on how to use and dose the drug. Patients should not arbitrarily stop the drug, change the dose of the drug, ... without the permission of the doctor to avoid unpredictable complications.
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