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Argistad 500 has the main active ingredient is L-Arginin HCl with the content of 500mg and other excipients in sufficient quantity. Argistad 500 belongs to the group of drugs for the gastrointestinal tract.
1. What is Argistad 500?
Argistad 500 is a prescription medicine with the main active ingredient being L-arginin hydrochloride equivalent to 500mg and other excipients in sufficient quantities. The drug is prepared in the form of hard capsules, suitable for direct oral use.
1.1. Pharmacodynamics of the active ingredient The main active ingredient L- arginine is a drug that acts on the liver and lowers ammonia in the blood.
1.2. The effect of active ingredients Active ingredient L-arginine plays the role of activating the synthesis of N-acetyl glutamic acid, activating the synthesis of carbamoyl phosphate to participate in the urea cycle. In cases of impaired urea production due to genetic causes, use drugs containing the active ingredient Arginin, which increases detoxification and elimination of ammonia in the form of citrulline or arginosuccinic acid.
2. What is the use of Argistad 500?
Argistad 500 is used in the treatment of the following diseases:
Maintenance treatment of hyperammonemia for people with deficiency of the enzyme carbamine phosphate synthetase, ornithine transcarbamylase. Maintenance treatment for people with hyperammonemia, citrulin in the blood, arginosuccinicuria. Supportive treatment for people with dyspepsia. Adjuvant therapy is intended to improve exercise capacity in individuals with stable cardiovascular disease. Nutritional supplementation for people with urea cycle disorders such as hyperammonemia type I and II, hypercitrulinity, deficiency of N-acetylglutamate synthase enzyme, argininosuccinicuria.
3. Usage and dosage of Argistad 500
3.1. How to use the drug Argistad 500 is made in the form of hard capsules, suitable for direct oral use.
3.2. Dosage of the drug Argistad 500 for both adults and children. However, for infants and young children who have difficulty in taking tablets, it is recommended to use liquid preparations. Depending on each subject and specific pathological condition, there is an appropriate dose and duration of treatment, below is the dose of Arginine for reference:
Maintenance treatment of hyperammonemia for people with deficiency enzyme carbamine phosphate synthetase, ornithine transcarbamylase: Infants and children aged 1-18 months take 3-4 times a day, 100mg/kg per day Maintenance treatment for people with hyperammonemia with citrulinemia, arginosuccinicuria: Infants and children from 1 to 18 months of age take 3-4 times a day, 100- 175 mg/kg each time, take the drug in combination with food, adjust the treatment dose according to the response of each specific person. Supportive treatment for people with indigestion: Adults take 3-6g per day, equivalent to 6 to 12 tablets/day. Supportive treatment to improve exercise capacity in people with stable cardiovascular disease: Adults take 6-21 g daily, each drug use should not exceed 8 g. Nutritional supplementation for people with urea cycle disorders such as hyperammonemia type I and II, hypercitrulinemia, deficiency of the enzyme N-acetylglutamate synthase, arginine in the urine: Adults take 3-20g daily depending on the condition of the patient. specific person.
4. Undesirable effects of the drug Argistad 500
During the use of Argistad 500, you may experience some undesirable effects, specifically as follows:
Distension and abdominal pain, decreased platelets, increased cyanosis of extremities, sickle cell anemia , increased BUN, creatinine and serum creatine. There are signs of an allergic reaction such as red rash, swelling of the hands and face, these signs and symptoms will subside quickly when the drug is stopped and diphenhydramine is added. Increased potassium in the blood for people with liver and kidney disease, diabetes, decreased phosphorus in the blood for people with diabetes.
5. Interactions of Argistad 500
Thiazide diuretics, xylitol and aminophyline when used together with Argistad 500 may result in higher plasma insulin concentrations. Long-term use of oral sulfonylureas for diabetes may inhibit the response of plasma glucagon to arginine. When glucose is administered to individuals with glucose intolerance, phenytoin reduces the plasma insulin response to Argistad 500. The use of Argistad 500 with potassium-sparing diuretics increases the risk of hyperkalemia, and the use of Arginin in the treatment of metabolic alkalosis in people with severe liver disease who have recently used Spironolactone may also occur. increase potassium in the blood.
6. Some notes when using Argistad 500
6.1. Note when using the drug Argistad 500 is a prescription drug, so it is not recommended to use it on your own, patients only use it when prescribed by a doctor. Read the instructions for use carefully before using Argistad 500. When there are any abnormal symptoms or signs, you must contact the treating doctor or medical facility for guidance and timely treatment. Keep out of reach of children, do not use Argistad 500 after the expiry date. When a dose is missed, just use the next dose, do not arbitrarily double the prescribed dose. 6.2. Precautions while using the drug For pregnant women: There are currently no adequate and well-controlled studies in pregnant women, so the drug should not be used during pregnancy. For lactating women: Amino acids are secreted into breast milk in very small quantities. However, it is not known whether the active substance Arginine is excreted in human milk in significant amounts. Therefore, caution should be exercised when using Argistad 500 in lactating women. It is necessary to weigh the benefits of using this drug in treatment for mother and child to choose the appropriate time to use the drug or stop breastfeeding. Arginine can alter the ratio of extracellular to intracellular potassium, causing hyperkalemia, which can be dangerous for people with kidney failure. Therefore, Argistad 500 should be used with caution in people with kidney disease and anuria. In the treatment of acute hyperammonemia, metabolic acidosis may occur when high doses of arginine are used due to hyperchloremia. Therefore, you should monitor the plasma chloride and bicarbonate concentration, and add the appropriate amount of bicarbonate. The active ingredient Arginin contains a high concentration of metabolizable nitrogen, so the temporary effects of high nitrogen should be assessed before initiating treatment with Argistad 500. Argistad 500 should not be used by people after a heart attack. The drug Argistad 500 has the main active ingredient is L-Arginin HCl with the content of 500mg and other excipients in a sufficient amount. Argistad 500 belongs to the group of drugs for the gastrointestinal tract. Patients need to strictly follow the instructions of the doctor, pharmacist to ensure effectiveness and avoid unwanted side effects.
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