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Anaflam 50 is an anti-inflammatory and analgesic drug commonly prescribed for moderate to severe pain and inflammation. The drug can cause serious side effects on the gastrointestinal tract if used improperly and misused, before taking the drug, it is necessary to learn information about the drug to be able to use it correctly.1. What is Anaflam 50?
Anaflam 50 has the main ingredient Diclofenac potassium 50 mg, which is formulated in the form of film-coated tablets. Diclofenac is a rapidly acting, nonsteroidal anti-inflammatory drug that makes it particularly suitable for the treatment of moderate to severe pain and acute inflammation. The drug also has antipyretic effect but is rarely used for this purpose.
The effect of the drug, like other anti-inflammatory drugs, is to inhibit prostaglandin biosynthesis. Prostaglandins play a huge role in causing inflammation, pain, and fever.
Diclofenac has been shown to have a strong analgesic effect in moderate to severe pain. When an inflammatory reaction occurs, such as inflammation caused by trauma, gout or surgical intervention, medications can rapidly relieve both spontaneous pain and pain associated with movement.
Clinical studies have also shown that with primary dysmenorrhea, this active ingredient has the ability to reduce pain and reduce the degree of bleeding.
In migraine headaches, Diclofenac has been shown to reduce headaches and improve other symptoms such as nausea and vomiting.
2. Indications and contraindications of Anaflam 50
Indications:
Can be used for long-term treatment of symptoms in rheumatoid arthritis; osteoarthritis and ankylosing spondylitis of the spine ; Fiessiger-Leroy-Reiter syndrome and rheumatism in psoriasis; Arthritis causes pain and disability. Short-term symptomatic treatment of acute attacks: Rheumatic diseases; post-traumatic acute injury; inflammation around the forearm shoulder joint; tendonitis ; bursitis; synovitis; bursitis tendonitis; Microcrystalline arthritis; Low back pain; disc herniation; Acute gout attack; Spine pain syndrome; extra-articular rheumatic diseases and postoperative pain relief. Also for short-term treatment of migraine attacks; Renal colic, biliary colic; Pain relief after surgery or orthodontics. Contraindications:
Progressive gastric or duodenal ulcer; Patients with hypersensitivity to any of the active ingredients. The drug is contraindicated in patients with known bronchial asthma, urticaria, or acute rhinitis when taking acetylsalicylic acid or other prostaglandin synthesis inhibitors. People with asthma or bronchospasm, bleeding, cardiovascular disease, severe kidney failure or severe liver failure. You are taking any anticoagulant (coumarin, antiplatelet agent). People with congestive heart failure, volume depletion due to diuretics or renal failure, glomerular filtration rate < 30 ml/min People with colloid disease: Because there is a risk of aseptic meningitis. . Pregnant women in the last 3 months of pregnancy.
3. Dosage and how to use Anaflam 50
How to use:
Take this medicine with water and should take it right before a meal. Do not break or chew the tablet, but swallow it whole.
Dosage:
For adults:
In case of severe pain, use a dose of 100 to 150mg divided into several times, 2 to 3 times. Milder pain can be used with a dose of 75 to 150 mg / day and divided into 2 to 3 times. Dysmenorrhea: The daily dose can be 50 to 200mg divided into several times, should be taken with an initial dose of 50 to 100mg. Use the drug from the time the symptoms appear and then a few days later depending on the symptoms. During a migraine attack: Initial dose is 50mg, then 2 hours later, if there is no reduction, a further dose of 50mg can be added, possibly 50mg every 4 to 6 hours, but not to exceed 200mg/24 hours. Children under 14 years old: can be used with a dose of 1-3mg/kg/day, divided into 2 to 3 times.
Overdose:
Overdose can cause symptoms such as excessive hypotension, renal failure, convulsions, stomach and intestinal irritation, respiratory failure. Overdose can be managed with supportive and symptomatic measures.
4. Anaflam 50 . side effects
Possible side effects when taking the drug include:
Epigastric pain, vomiting, diarrhea, abdominal pain, indigestion, flatulence, loss of appetite. Rarely, gastrointestinal bleeding, hematemesis, bloody stools, melena, gastrointestinal bleeding or perforation have been reported. headache, lightheadedness, dizziness, fatigue; Sensory disturbances, memory disturbances, disorientation, visual disturbances (amblyopia, double vision), hearing loss, insomnia, excitability, convulsions, depression, anxiety, nightmares , psychomotor reactions, taste disturbances. Allergic reactions: From mild to severe such as rash, urticaria, rarely causing erythema multiforme, Stevens Johnson syndrome, Lyell's syndrome, alopecia, photosensitive reactions, allergic purpura; Hypersensitivity reactions such as asthma, anaphylactic reactions including hypotension. Acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, renal papillary necrosis. Increased serum transaminases (SGOT, SGPT). Hepatitis rarely occurs, which can occur suddenly in some cases. Increased risk of stroke and myocardial infarction due to the increased risk of blood clots in the heart; palpitations, chest pain ; high blood pressure; heart failure. These are rare but serious side effects When you experience any unwanted effects while taking this medicine, to be safe you should stop taking the medicine and notify your doctor for timely treatment.
5. Note when using Anaflam 50
Drugs should be used only when indicated and patients need to be closely monitored in people with symptoms or conditions such as gastrointestinal disorders, a history of peptic ulcer disease, ulcerative colitis, Crohn's disease, Patients with liver dysfunction, lupus erythematosus, infections, blood clotting disorders, the elderly.
When using the drug, it is necessary to strictly follow the instructions and dose and time of use of the doctor. Avoid taking it for a longer time or increasing the dose on your own.
Because of the important nature of prostaglandins in maintaining renal perfusion, special caution should be taken when administering this drug to patients with heart or kidney damage, the elderly, patients taking diuretics and the patient is hypovolemic, regardless of the cause. Due to increased kidney damage and increased risk of thromboembolic stroke.
This medicine may cause an increase in one or more liver enzymes. Therefore, careful monitoring of liver function should be performed in case the patient requires prolonged use of the drug. When abnormal liver function test results persist or worsen, or when clinical signs or symptoms of liver disease occur, the drug should be discontinued. Hepatitis can also occur without warning, so regular evaluation is necessary to detect hepatitis early and treat promptly.
When taking the drug, if the patient feels dizzy or has a central nervous system disorder, do not drive or operate machinery.
Pregnant women: Use this medicine with caution in pregnant women, it is best not to use it. Do not use systemic drugs in the last 3 months of pregnancy (due to the risk of heart, lung, kidney toxicity for the fetus, the risk of prolonging bleeding time may be encountered in the mother and in the baby).
Lactating women: In a study, after taking a dose of 50 mg over a period of 8 hours, the active ingredient of the drug can pass into breast milk in small amounts. Therefore, lactating women need to be very careful.
Drug interactions: Combining several drugs together increases the risk of side effects or toxicity. Beware of the following drug combinations.
In case of concomitant prescription, diclofenac may increase blood levels of lithium and the drug digoxin. Increased risk of poisoning with these two drugs. Many non-steroidal anti-inflammatory drugs can inhibit the action of diuretics. Concomitant treatment with potassium-sparing diuretics increases the risk of hyperkalemia and therefore requires monitoring. Concomitant administration of multiple nonsteroidal anti-inflammatory drugs or glucocorticoids increases the incidence of gastrointestinal adverse effects, and therefore, increased monitoring is required in these patients. Caution is advised when non-steroidal anti-inflammatory drugs are administered less than 24 hours before or after initiating methotrexate therapy because of the potential for increased blood levels and toxicity. The nephrotoxicity of cyclosporin is increased when co-administered with non-steroidal anti-inflammatory drugs. Because steroid anti-inflammatory drugs reduce renal perfusion. Quinolone antibiotics: When taken with non-steroidal anti-inflammatory drugs may increase the risk of convulsions. Hopefully, through the article you know the uses and things to keep in mind when using the drug. Use according to indications and monitor for abnormal signs while taking the drug to ensure early detection and prevent the risk of unwanted drug effects.
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